Cardinals vs. Colts Odds & Betting Predictions - October 12, 2025

Why not

X: @PicksOffice

Played on ProphetX

Even if Cardinals are road dogs and Kyler might not play, hard to pass on a RB1 at +200 or better.

Both of these teams started out a surprise 2-0, but it's been a wide departure since. The Cardinals have lost all three games, dropping to 2-3, though all five Arizona games have finished within one score. The Colts continue to run it up with big wins over terrible Dolphins, Titans, and Raiders defenses, but neither of these teams has played a tough schedule. This should be a much fairer fight, and Colts -7.5 feels rich. I'm not eager to back the Cardinals right now with the offense, but I make this closer to -4 or -5, and I think those extra couple Indy points are being baked into the total too, so let's go with an under. Arizona's defense has played pretty well so far after investing heavily into a flurry of additions this offseason. The Cardinals rank top 10 in Defensive DVOA, including top 10 against both the run and the pass. The Colts defense has also played well after a huge upgrade to DC Lou Anarumo. It currently ranks top five overall and against the pass, and though that feels a bit inflated, there's no doubt it's playing well. In a surprise twist from preseason expectations, Arizona's offense looks like the weakest unit on the field. The Cards rank bottom 10 by DVOA and have especially struggled to run the ball effectively after the departure of assistant coach Klayton Adams and the loss of their top two running backs. Cardinals games are averaging just 39.8 points on the season, with one game at 49 and the others below our total of 47.5. No team has topped 27 points in any Arizona game yet this season. It remains to be seen whether Kyler Murray will give it a go, but obviously a limited Murray or an appearance by Jacoby Brissett only hurts Arizona's offense further. Murray road unders are 68% for his career, and Jonathan Gannon road unders are 67%. Daniel Jones home unders are also 70% for his career, including 2-1 this season on a new team. Don't wait around for Murray news, because this total will likely drop a bit if he's ruled out. Key numbers are tricky with totals, but 47 is one of the most important, so we want to grab 47.5 above that number and play the value on the under.

Projecting his median closer to 61.5 with around a 59% chance to clear 52.5 (he has a wide range of outcomes). Cards have a +31% expected trail rate here and it’s not quite “Monty back in Cincy” level projections boost, but MHJ will be playing where his father played for his entire HOF career for the first time.

@GDAWG5000 https://myaction.app/QzEiDAmkmXb

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I may bet against the Cardinals every game from here on out out of sheer spite.