Panthers vs. 49ers Odds & Betting Predictions - November 25, 2025
Panthers at 49ers
1:15 am • ESPNPanthers at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Panthers 6-5 | +7.5 | +7.5-115 | o49-110 | +310 |
49ers 7-4 | u49.5 | -7.5-105 | u49-110 | -375 |

Levi's StadiumSanta Clara
Panthers vs. 49ers Expert Picks
Sandy Plashkes
Last 30d: 127-145-7 (-21.4u)
Over 44 (Live)-114
2.28u
Mjaybrod
Last 30d: 142-120-0 (+27.3u)
Over 49-110
1u
Points
Matt DiLeo
Last 30d: 51-43-5 (+1.1u)
J.Sanders o17.5 Rec Yds-112
1u
X.Legette o13.5 Longest Reception-115
1u
Sir Lockselot
Last 30d: 21-75-0 (-63.1u)
T.McMillan Anytime TD Scorer Yes+155
1.5u
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CAR +7+100
3u
📚Player Profit
🔑 Panthers +7 +100 (Player Profit) 3u
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Mjaybrod
Last 30d: 142-120-0 (+27.3u)
R.Dowdle o17.5 Rush Att-110
1u
Streaking after so many L’s
Markus Markets
Last 30d: 48-49-3 (+5.6u)
B.Young o205.5 Pass Yds-126
1u
The Degenerates
Last 30d: 82-84-2 (-7.9u)
C.McCaffrey o5.5 Recs+105
1u
Invisible Insider
Last 30d: 8-6-0 (+1.6u)
T.McMillan o65.5 Rec Yds-116
1u
4 Insiders are backing this play.
Sean Koerner
Last 30d: 50-35-0 (+7.8u)
B.Purdy u10.5 Rush Yds-112
0.56u
Earlier this morning I wasn’t seeing much value on the board. The market looked sharp, so I moved on to my Week 13 projections assuming I would sit this one out. But almost all the action has been on Purdy’s rush over, which pushed his line from 7.5 up to 10.5. That is a massive move for a QB rush prop. I agreed with the opening number and think the inflation gives us a good chance to hit the under.
I’ve been saying since early 2023 that Purdy had more rushing upside than people realized. He has great short-area speed and I even said he could offer Mahomes-like rushing upside. And he has. He can rip off big runs when he wants, so this prop always comes with risk. He can erase it with one scramble. But I think this is the right spot to fade him.
Purdy came back from a toe injury last week and I wasn’t expecting him to run much. He didn’t. His only carry was a broken play where Brian Robinson Jr. wasn’t on the same page and Purdy basically sat down because he saw 300-pound Walter Nolen charging at him. He looked like a man who had zero interest in taking off to run when that play broke down.
He should be closer to 100% tonight, so I expect he will run if he has to, but he may not have to. The Panthers have the 3rd lowest pressure rate in the league, so Purdy should have a clean pocket and be able to stay in rhythm instead of taking off. They also do a good job limiting QB rushing in general. @nick_giffen noted they have the 4th lowest scramble rate over expected. They’ve also allowed the 5th lowest yards per scramble at 6.1 yards. They’ve kept good running QBs in check: Drake Maye (3/11/1), Josh Allen (3/7/2), Justin Fields (4/22/0).
I have Purdy for 1-2 scrambles tonight. If he gets both he might sneak over, but there’s also a real chance those extra yards get wiped out by kneel downs (7.5 point favorites). Mac Jones was the QB sneak guy in this offense, not Purdy. They didn’t use Purdy that way last week and they may want to protect him given the recent injury.
I have his median closer to 7.5 which was the opener. My sim has about a 10% chance he finishes in the 8-10 yard range. That gives me roughly a 60% chance he stays under 10.5.
C’mon Purdy, be a Mall Santa 🎅 for me for one more week.
Vegas Refund
Last 30d: 38-43-1 (-9.3u)
CAR +7.5-112
1.12u
Bet Labs
Last 30d: 25-26-0 (+2.6u)
CAR +7.5-118
1.18u
YBK Picks.com
Last 30d: 42-40-1 (+1.3u)
Over 49.5-105
3u
💰🦡 Jake
Last 30d: 85-110-6 (-16.7u)
Over 49.5-110
2.2u
G.Kittle o56.5 Rec Yds-110
1.1u
B.Young o206.5 Pass Yds-112
1.12u
Player Prop Savant
Last 30d: 42-48-0 (-13.5u)
T.Moehrig o7.5 Tackles + Ast+103
1u
💰🦡 Jake
Last 30d: 85-110-6 (-16.7u)
CAR +5.5 (1H)-115
1.15u
Nick Giffen
Last 30d: 59-72-1 (+12.8u)
B.Young o20.5 Pass Comp+101
0.5u
Action Island
J.Sanders o2.5 Recs+110
0.5u
Action Island
Roger Goodell
Last 30d: 40-45-0 (-0.3u)
SF -7.5-104
0.5u
Over 49-110
0.5u
Grant Neiffer
Last 30d: 46-83-10 (+4.5u)
B.Young 275+ Passing Yards Yes+475
0.1u
B.Young 325+ Passing Yards Yes+1500
0.1u
B.Young 300+ Passing Yards Yes+900
0.1u
B.Young 250+ Passing Yards Yes+250
0.2u
Brandon Anderson
Last 30d: 54-144-4 (+11.2u)
G.Kittle Anytime TD Scorer Yes+145
0.5u
MNF pick from Action Network podcast
G.Kittle 2+ TDs Yes+1100
0.1u
MNF pick from Action Network podcast
G.Kittle o54.5 Rec Yds-112
0.5u
MNF pick from Action Network podcast
Mjaybrod
Last 30d: 142-120-0 (+27.3u)
R.Dowdle o74.5 Rush Yds-110
1u
Run it up the gut
Grant Neiffer
Last 30d: 46-83-10 (+4.5u)
B.Young o207.5 Pass Yds-114
1.14u
B.Robinson Anytime TD Scorer Yes+475
0.25u
G.Kittle Anytime TD Scorer Yes+140
0.5u
Sandy Plashkes
Last 30d: 127-145-7 (-21.4u)
R.Pearsall o40.5 Rec Yds-114
1.14u
Action Pod NFL Picks
Last 30d: 73-157-3 (-0.6u)
B.Robinson Anytime TD Scorer Yes+425
0.24u
@EvanHAbrams https://myaction.app/L4IXscUCyYb
G.Kittle Anytime TD Scorer Yes+145
0.69u
@wheatonbrando https://myaction.app/L4IXscUCyYb
T.McMillan o65.5 Rec Yds-112
1u
@EvanHAbrams https://myaction.app/L4IXscUCyYb
G.Kittle 2+ TDs Yes+1100
0.1u
@wheatonbrando https://myaction.app/L4IXscUCyYb
G.Kittle o54.5 Rec Yds-110
1u
@wheatonbrando https://myaction.app/L4IXscUCyYb
Moneyline Hacks
Last 30d: 153-153-3 (+44.5u)
B.Purdy o7.5 Rush Yds-110
1u
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Dale Tanhardt
Last 30d: 4-11-0 (+1.0u)
B.Purdy Anytime TD Scorer Yes+500
0.5u
K.Juszczyk Anytime TD Scorer Yes+1000
0.3u
Gilles Gallant
Last 30d: 23-75-0 (-7.2u)
X.Legette Anytime TD Scorer Yes+450
0.5u
J.Jennings Anytime TD Scorer Yes+225
0.5u
Boomer Betz
Last 30d: 212-201-11 (+23.3u)
SF u30.5-125
1.25u
@braydenhenry
TAN Pod Touchdown Show
Last 30d: 30-112-1 (-6.8u)
B.Robinson Anytime TD Scorer Yes+450
0.5u
@The_Oddsmaker https://myaction.app/XiJckG31tYb
X.Legette Anytime TD Scorer Yes+400
0.5u
@ChrisRaybon https://myaction.app/XiJckG31tYb
J.Jennings Anytime TD Scorer Yes+195
0.5u
@GDAWG5000 https://myaction.app/XiJckG31tYb
Roger Goodell
Last 30d: 40-45-0 (-0.3u)
B.Robinson o21.5 Rush Yds-110
0.5u
T.McMillan o61.5 Rec Yds-115
0.5u
Kenny Ducey
Last 30d: 21-21-1 (-1.2u)
CAR +7-110
1.1u
Cam Is Money
Last 30d: 120-120-3 (-7.7u)
G.Kittle o54.5 Rec Yds-117
1u
Will Brinson
Last 30d: 21-26-3 (-5.0u)
Over 47.5-111
1.11u
FD. Should close closer to 49
Stuck 🚨
Last 30d: 55-64-1 (-3.7u)
CAR +7+100
0.5u
FTN Fantasy
Last 30d: 116-145-2 (-38.7u)
SF -7-112
1u
Panthers vs. 49ers Previews & Analysis
Panthers vs. 49ers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Panthers vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 2-3 in their last 5 games.
- 49ers are 2-3 in their last 5 games against the spread
- 49ers are 5-2 in their road games against the spread
- The totals have gone OVER in 3 of 49ers' last 5 games
- The totals have gone OVER in 2 of 49ers' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Panthers Injury Updates

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan JamesRB
James is doubtful with finger
Doubtful

Panthers Injuries
- David MooreWR
Moore is out with elbow
Out
- Damarri MathisCB
Mathis is out with knee
Out
Team Stats
Panthers vs. 49ers Odds Comparison
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Panthers at 49ers Team Totals
MatchupOverUnder | ||
|---|---|---|
Panthers 6-5 | N/A | N/A |
49ers 7-4 | N/A | N/A |




