Panthers vs. 49ers Odds & Betting Predictions - November 25, 2025

Panthers at 49ers

1:15 am • ESPN
0 - 7

Panthers at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Panthers
6-5
+7.5
+7.5-115
o49-110
+310
49ers
7-4
u49.5
-7.5-105
u49-110
-375
location pinTuesday 1:15 a.m.
November 25, 2025
Levi's StadiumSanta Clara
Panthers vs. 49ers Expert Picks
Sandy Plashkes
Sandy Plashkes
Last 30d: 127-145-7 (-21.4u)
Over 44 (Live)-114
2.28u
Mjaybrod
Mjaybrod
Last 30d: 142-120-0 (+27.3u)
Over 49-110
1u
Points
Matt DiLeo
Matt DiLeo
Last 30d: 51-43-5 (+1.1u)
J.Sanders o17.5 Rec Yds-112
1u
X.Legette o13.5 Longest Reception-115
1u
Sir Lockselot
Sir Lockselot
Last 30d: 21-75-0 (-63.1u)
T.McMillan Anytime TD Scorer Yes+155
1.5u
📚Player Profit 🔑 T.McMillan ATTD +155 (Player Profit) 1.5u Wet for Tet! Code: sirlocks for 10% off when you get funded at https://www.playerprofit.com/
CAR +7+100
3u
📚Player Profit 🔑 Panthers +7 +100 (Player Profit) 3u Panthers are elite ATS especially as dogs, 7-3 this season. 4-2 ATS on the road. Panthers are live tn! Code: sirlocks for 10% off when you get funded at https://www.playerprofit.com/
Mjaybrod
Mjaybrod
Last 30d: 142-120-0 (+27.3u)
R.Dowdle o17.5 Rush Att-110
1u
Streaking after so many L’s
Markus Markets
Markus Markets
Last 30d: 48-49-3 (+5.6u)
B.Young o205.5 Pass Yds-126
1u
The Degenerates
The Degenerates
Last 30d: 82-84-2 (-7.9u)
C.McCaffrey o5.5 Recs+105
1u
Invisible Insider
Invisible Insider
Last 30d: 8-6-0 (+1.6u)
T.McMillan o65.5 Rec Yds-116
1u
4 Insiders are backing this play.
Sean Koerner
Sean Koerner
Last 30d: 50-35-0 (+7.8u)
B.Purdy u10.5 Rush Yds-112
0.56u
Earlier this morning I wasn’t seeing much value on the board. The market looked sharp, so I moved on to my Week 13 projections assuming I would sit this one out. But almost all the action has been on Purdy’s rush over, which pushed his line from 7.5 up to 10.5. That is a massive move for a QB rush prop. I agreed with the opening number and think the inflation gives us a good chance to hit the under. I’ve been saying since early 2023 that Purdy had more rushing upside than people realized. He has great short-area speed and I even said he could offer Mahomes-like rushing upside. And he has. He can rip off big runs when he wants, so this prop always comes with risk. He can erase it with one scramble. But I think this is the right spot to fade him. Purdy came back from a toe injury last week and I wasn’t expecting him to run much. He didn’t. His only carry was a broken play where Brian Robinson Jr. wasn’t on the same page and Purdy basically sat down because he saw 300-pound Walter Nolen charging at him. He looked like a man who had zero interest in taking off to run when that play broke down. He should be closer to 100% tonight, so I expect he will run if he has to, but he may not have to. The Panthers have the 3rd lowest pressure rate in the league, so Purdy should have a clean pocket and be able to stay in rhythm instead of taking off. They also do a good job limiting QB rushing in general. @nick_giffen noted they have the 4th lowest scramble rate over expected. They’ve also allowed the 5th lowest yards per scramble at 6.1 yards. They’ve kept good running QBs in check: Drake Maye (3/11/1), Josh Allen (3/7/2), Justin Fields (4/22/0). I have Purdy for 1-2 scrambles tonight. If he gets both he might sneak over, but there’s also a real chance those extra yards get wiped out by kneel downs (7.5 point favorites). Mac Jones was the QB sneak guy in this offense, not Purdy. They didn’t use Purdy that way last week and they may want to protect him given the recent injury. I have his median closer to 7.5 which was the opener. My sim has about a 10% chance he finishes in the 8-10 yard range. That gives me roughly a 60% chance he stays under 10.5. C’mon Purdy, be a Mall Santa 🎅 for me for one more week.
Vegas Refund
Vegas Refund
Last 30d: 38-43-1 (-9.3u)
CAR +7.5-112
1.12u
Bet Labs
Bet Labs
Last 30d: 25-26-0 (+2.6u)
CAR +7.5-118
1.18u
YBK Picks.com
Last 30d: 42-40-1 (+1.3u)
Over 49.5-105
3u
💰🦡 Jake
💰🦡 Jake
Last 30d: 85-110-6 (-16.7u)
Over 49.5-110
2.2u
G.Kittle o56.5 Rec Yds-110
1.1u
B.Young o206.5 Pass Yds-112
1.12u
Player Prop Savant
Player Prop Savant
Last 30d: 42-48-0 (-13.5u)
T.Moehrig o7.5 Tackles + Ast+103
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 85-110-6 (-16.7u)
CAR +5.5 (1H)-115
1.15u
Nick Giffen
Nick Giffen
Last 30d: 59-72-1 (+12.8u)
B.Young o20.5 Pass Comp+101
0.5u
Action Island
J.Sanders o2.5 Recs+110
0.5u
Action Island
Roger Goodell
Roger Goodell
Last 30d: 40-45-0 (-0.3u)
SF -7.5-104
0.5u
Over 49-110
0.5u
Grant Neiffer
Grant Neiffer
Last 30d: 46-83-10 (+4.5u)
B.Young 275+ Passing Yards Yes+475
0.1u
B.Young 325+ Passing Yards Yes+1500
0.1u
B.Young 300+ Passing Yards Yes+900
0.1u
B.Young 250+ Passing Yards Yes+250
0.2u
Brandon Anderson
Brandon Anderson
Last 30d: 54-144-4 (+11.2u)
G.Kittle Anytime TD Scorer Yes+145
0.5u
MNF pick from Action Network podcast
G.Kittle 2+ TDs Yes+1100
0.1u
MNF pick from Action Network podcast
G.Kittle o54.5 Rec Yds-112
0.5u
MNF pick from Action Network podcast
Mjaybrod
Mjaybrod
Last 30d: 142-120-0 (+27.3u)
R.Dowdle o74.5 Rush Yds-110
1u
Run it up the gut
Grant Neiffer
Grant Neiffer
Last 30d: 46-83-10 (+4.5u)
B.Young o207.5 Pass Yds-114
1.14u
B.Robinson Anytime TD Scorer Yes+475
0.25u
G.Kittle Anytime TD Scorer Yes+140
0.5u
Sandy Plashkes
Sandy Plashkes
Last 30d: 127-145-7 (-21.4u)
R.Pearsall o40.5 Rec Yds-114
1.14u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 73-157-3 (-0.6u)
B.Robinson Anytime TD Scorer Yes+425
0.24u
G.Kittle Anytime TD Scorer Yes+145
0.69u
T.McMillan o65.5 Rec Yds-112
1u
G.Kittle 2+ TDs Yes+1100
0.1u
G.Kittle o54.5 Rec Yds-110
1u
Moneyline Hacks
Moneyline Hacks
Last 30d: 153-153-3 (+44.5u)
B.Purdy o7.5 Rush Yds-110
1u
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Dale Tanhardt
Dale Tanhardt
Last 30d: 4-11-0 (+1.0u)
B.Purdy Anytime TD Scorer Yes+500
0.5u
K.Juszczyk Anytime TD Scorer Yes+1000
0.3u
Gilles Gallant
Gilles Gallant
Last 30d: 23-75-0 (-7.2u)
X.Legette Anytime TD Scorer Yes+450
0.5u
J.Jennings Anytime TD Scorer Yes+225
0.5u
Boomer Betz
Boomer Betz
Last 30d: 212-201-11 (+23.3u)
SF u30.5-125
1.25u
@braydenhenry
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 30-112-1 (-6.8u)
B.Robinson Anytime TD Scorer Yes+450
0.5u
X.Legette Anytime TD Scorer Yes+400
0.5u
J.Jennings Anytime TD Scorer Yes+195
0.5u
Roger Goodell
Roger Goodell
Last 30d: 40-45-0 (-0.3u)
B.Robinson o21.5 Rush Yds-110
0.5u
T.McMillan o61.5 Rec Yds-115
0.5u
Kenny Ducey
Kenny Ducey
Last 30d: 21-21-1 (-1.2u)
CAR +7-110
1.1u
Cam Is Money
Cam Is Money
Last 30d: 120-120-3 (-7.7u)
G.Kittle o54.5 Rec Yds-117
1u
Will Brinson
Will Brinson
Last 30d: 21-26-3 (-5.0u)
Over 47.5-111
1.11u
FD. Should close closer to 49
Stuck 🚨
Stuck 🚨
Last 30d: 55-64-1 (-3.7u)
CAR +7+100
0.5u
FTN Fantasy
FTN Fantasy
Last 30d: 116-145-2 (-38.7u)
SF -7-112
1u

Panthers vs. 49ers Previews & Analysis

  • Panthers vs. 49ers Best Bets: 6 Picks, Props for Monday Night Football article feature image

    Panthers vs. 49ers Best Bets: 6 Picks, Props for Monday Night Football

    Action Network Staff
    Nov 24, 2025 UTC
  • Panthers vs. 49ers: Stuckey's Spread Pick for Monday Night Football article feature image

    Panthers vs. 49ers: Stuckey's Spread Pick for Monday Night Football

    Stuckey
    Nov 24, 2025 UTC
  • Koerner's Brock Purdy Prop for MNF article feature image

    Koerner's Brock Purdy Prop for MNF

    Sean Koerner
    Nov 24, 2025 UTC
  • Spread Pick, TD Prediction Form +1957 SGP article feature image

    Spread Pick, TD Prediction Form +1957 SGP

    Alex Kolodziej
    Nov 24, 2025 UTC
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Panthers vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Panthers vs. 49ers Public Betting Percentages

Away Logo

Panthers

Public

43%

Bets%

57%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers
6-51-35-24-22-3
Panthers
7-43-24-20-17-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers
7-42-25-24-23-2
Panthers
6-53-23-30-16-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers
7-4N/AN/A5-12-3
Panthers
6-5N/AN/A0-16-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 16th@ARIW 41-22-3.5 WO 48.5SF -192
Nov 9thLAL 26-42+5.5 LO 49.5LA +212
Nov 2nd@NYGW 34-24-2.5 WO 47.5SF -146
Oct 26th@HOUL 15-26+3 LU 41.5HOU +130
Oct 20thATLW 20-10-0.5 WU 46.5SF -105

49ers vs. Panthers Injury Updates

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Panthers Injuries

  • David Moore
    WR

    Moore is out with elbow

    Out

  • Damarri Mathis
    CB

    Mathis is out with knee

    Out

Team Stats
32
Total Yards
85
7
Total Plays
18
4.6
Yards Per Play
4.7
3
YDS
42
1/2
Comps/Atts
7/9
1.5
YPA
4.667
0/1
TDs/INTs
1/1
0/0
Sacks/Yards
0/0
29
Rush Yards
43
5
Attempts
9
5.8
YPC
4.778
0
TDs
0

Turnovers

0
Fumbles Lost
0
1
Interceptions
1

Efficiency

0/1 0%
Redzone
1/1 100%
1/2 0%
3rd Down
3/3 0%
0/0 0%
4th Down
0/0 0%

First Downs

1
Total
7
0
Pass
4
1
Rush
3
0
Penalty
0
1/10
Penalties/Yards
0/0
4:44
Possession
9:45

Panthers vs. 49ers Odds Comparison

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Panthers at 49ers Team Totals

MatchupOverUnder
Panthers
6-5
N/A
N/A
49ers
7-4
N/A
N/A