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Panthers vs. 49ers Odds & Betting Predictions - November 25, 2025

Panthers at 49ers

1:15 am • ESPN

Carolina Panthers

5-4
@

San Francisco 49ers

6-3

Panthers at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Panthers
5-4
N/A
N/A
N/A
49ers
6-3
N/A
N/A
N/A
location pinTuesday 1:15 a.m.
November 25, 2025
Levi's StadiumSanta Clara

Panthers vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Panthers vs. 49ers Public Betting Percentages

Away Logo

Panthers

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 2-3 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 4-2 in their road games against the spread
  • The totals have gone OVER in 3 of 49ers' last 5 games
  • The totals have gone OVER in 1 of 49ers' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		5-41-24-23-22-2
Panthers		6-33-13-2N/A6-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		5-41-24-23-22-2
Panthers		5-43-12-3N/A5-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		6-3N/AN/A4-12-2
Panthers		5-4N/AN/AN/A5-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 2nd@NYGW 34-24-2.5 WO 47.5SF -146
Oct 26th@HOUL 15-26+3 LU 41.5HOU +130
Oct 20thATLW 20-10-0.5 WU 46.5SF -105
Oct 12th@TBL 19-30+3.5 LO 47TB +160
Oct 3rd@LAW 26-23+7.5 WO 43.5SF +340

49ers vs. Panthers Injury Updates

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Panthers Injuries

  • David Moore
    WR

    Moore is out with elbow

    Out

  • Damarri Mathis
    CB

    Mathis is out with knee

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Mac Jones logo
    Mac Jones
    1832
    pyds
  • passing touchdowns
    Mac Jones logo
    Mac Jones
    10
    ptd
  • rushing yards
    Christian McCaffrey logo
    Christian McCaffrey
    596
    ryds
  • rushing touchdowns
    Christian McCaffrey logo
    Christian McCaffrey
    4
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBrock PurdyMac JonesKurtis Rourke
RBChristian McCaffreyIsaac GuerendoJordan James
WRJauan JenningsJacob CowingSkyy MooreJunior Bergen
TEGeorge KittleLuke FarrellJake TongesBrayden Willis
LTTrent WilliamsSpencer Burford
LGBen BartchNick Zakelj
CJake BrendelMatt HennessyDrake Nugent
RGDominick PuniConnor Colby
RTColton McKivitzAusten Pleasants
LDENick BosaYetur Gross-MatosRobert BealWilliam Bradley-King
RDEMykel WilliamsBryce HuffSam Okuayinonu
WLBDee WintersNick MartinStone BlantonJalen Graham
MLBFred WarnerLuke GiffordTatum BethuneCurtis Robinson
LCBRenardo GreenJakob Robinson
SSJi'Ayir BrownMalik MustaphaDerrick Canteen
FSJason PinnockMarques SigleSiran Neal
RCBDeommodore LenoirDarrell Luter
PThomas Morstead
PRJacob CowingJunior BergenJordan WatkinsRicky Pearsall
KRIsaac GuerendoJunior Bergen
LSJon Weeks
NTJordan ElliottC.J. WestKalia Davis
NBUpton StoutChase Lucas
RWRRicky PearsallJordan WatkinsMalik Turner
FBKyle Juszczyk
DTKevin GivensAlfred CollinsSebastian ValdezEvan Anderson
LWRBrandon AiyukRussell GageMalik Turner
Team Stats

Passing

1538
YDS
2295
174/281
Comps/Atts
216/323
5.989
YPA
7.486
12/7
TDs/INTs
14/9
20/145
Sacks/Yards
18/123

Rushing

1258
Rush Yards
874
269
Attempts
249
4.677
YPC
3.51
6
TDs
5

Turnovers

Fumbles Lost
7
Interceptions
9

Efficiency

16/27 59.26%
Redzone
17/30 56.67%
42/112 0%
3rd Down
57/121 0%
15/21 0%
4th Down
7/12 0%

First Downs

185
Total
192
95
Pass
123
69
Rush
55
21
Penalty
14

Misc

/
Penalties/Yards
/
Possession

Panthers vs. 49ers Odds Comparison

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Panthers at 49ers Team Totals

MatchupOverUnder
Panthers
5-4
N/A
N/A
49ers
6-3
N/A
N/A