| Ezequiel Ponce | F | Out | Knee Injury | Knee Injury | Feb 15 |
| Alexander Callens | DEF | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Domagoj Vida | DEF | Out indefinitely | Abdominal Strain | Abdominal Strain | May 24 |
| Tyrone Mings | DEF | Out | Tyrone Mings is expected to return Early January 2026 from Hamstring Injury. | Mings is out with hamstring | Dec 5 |
| Ross Barkley | MID | Out | Ross Barkley is expected to return Early January 2026 from Knock injury. | Barkley is out with knock injury | Dec 5 |
| Boubacar Kamara | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Lucas Digne | DEF | Doubtful | Lucas Digne is Doubtful with Head injury. | Digne is doubtful with head | Sep 14 |
| Pau Torres | DEF | Out indefinitely | Knock | Knock | Apr 4 |
| Emiliano Buendia | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 27 |
| Remo Freuler | MID | Out | Remo Freuler is expected to return Early January 2026 from Shoulder injury. | Freuler is out with shoulder | Dec 5 |
| Lukasz Skorupski | GK | Out | Lukasz Skorupski is expected to return Late December 2025 from Thigh injury. | Skorupski is out with thigh | Dec 5 |
| Tommaso Pobega | MID | Out | Tommaso Pobega is expected to return Early October 2025 from Muscle injury. | Pobega is out with muscle | Sep 18 |
| Juan Miranda | DEF | Out indefinitely | Knock | Knock | Apr 11 |
| Joaquin Sosa | DEF | Out | Joaquín Sosa is expected to return Early October 2025 from Muscle injury. | Sosa is out with muscle | Sep 6 |
| Joao Moutinho | MID | Out | Ankle/Foot Injury | Ankle/Foot Injury | Aug 20 |
| Rodrigo Zalazar | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Jan 30 |
| Victor Gomez | DEF | Out | Suspended | Suspended | May 7 |
| Noah Jean Holm | F | Out | Back Injury | Back Injury | Apr 11 |
| Niklas Castro | F | Out | Niklas Castro is expected to return Early November 2025 from Thigh injury. | Castro is out with thigh | Oct 19 |
| Markus Haaland | MID | Out indefinitely | Markus Haaland will not play due to National team. | Haaland is injured with unknown | Sep 29 |
| Sakarias Opsahl | MID | Out | Sakarias Opsahl is expected to return Early November 2025 from Foot injury. | Opsahl is out with foot | Oct 21 |
| Thore Pedersen | DEF | Suspended | Thore Pedersen is serving a suspension for Yellow cards. | Pedersen is suspended with yellow cards | Oct 27 |
| Joachim Soltvedt | MID | Out | Joachim Soltvedt is expected to return Mid October 2025 from Knock injury. | Soltvedt is out with knock injury | Oct 1 |
| Jonas Tviberg Torsvik | DEF | Out | Jonas Torsvik is expected to return Early November 2025 from Knock injury. | Torsvik is out with knock injury | Oct 21 |
| Marcos Alonso | DEF | Out indefinitely | Knock | Knock | Sep 5 |
| Franco Cervi | F | Out | Suspended | Suspended | Oct 2 |
| Joseph Aidoo | DEF | Out | Joseph Aidoo is expected to return Late December 2025 from Hamstring Injury. | Aidoo is out with hamstring | Dec 6 |
| Luca De La Torre | MID | Out | Hamstring | Hamstring | Nov 22 |
| Manu Sanchez | MID | Out indefinitely | Hamstring | Hamstring | May 12 |
| Ilaix Moriba | MID | Out indefinitely | Hamstring | Hamstring | Dec 28 |
| Kasper Schmeichel | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Aug 14 |
| Cameron Carter-Vickers | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 25 |
| Arber Hoxha | F | Doubtful | Arbër Hoxha is Doubtful with Thigh injury. | Hoxha is doubtful with thigh | Sep 29 |
| Mateo Lisica | F | Out | Mateo Lisica is expected to return in About a week from Flu. | Lisica is out with illness | Dec 1 |
| Josip Misic | MID | Suspended | Josip Misic is serving a suspension for Yellow cards. | Misic is suspended with yellow cards | Nov 2 |
| Robert Mudrazija | MID | Out indefinitely | Robert Mudrazija is Unknown with Unknown. | Mudrazija is injured with unknown | Dec 6 |
| Luka Stojkovic | MID | Suspended | Luka Stojkovic is serving a suspension for Red card. | Stojkovic is suspended with red card | Sep 22 |
| Moreno Zivkovic | DEF | Out indefinitely | Moreno Zivkovic is Unknown with Knock injury. | Zivkovic is injured with knock injury | Nov 9 |
| Vito Caic | MID | Suspended | Vito Caic is serving a suspension for Red card. | Caic is suspended with red card | Oct 20 |
| Xherdan Shaqiri | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Dec 20 |
| Flavius Daniliuc | DEF | Out | Suspended | Suspended | Aug 7 |
| Ibrahim Salah | F | Doubtful | None | Salah is doubtful | May 16 |
| Metinho | MID | Suspended | Metinho is serving a suspension for Yellow cards. | Metinho is suspended with yellow cards | Nov 10 |
| Gabriel Sigua | MID | Out | Gabriel Sigua is expected to return in A few weeks from Muscle injury. | Sigua is out with muscle | Nov 6 |
| Denil Castillo | MID | Out | Denil Castillo is expected to return Mid December 2025 from Unknown. | Castillo is out with unknown | Nov 30 |
| Edward Chilufya | MID | Out | Edward Chilufya is expected to return Early November 2025 from Unknown. | Chilufya is out with unknown | Oct 19 |
| Junior Brumado | F | Out | Júnior Brumado is expected to return Early November 2025 from Illness. | Brumado is out with illness | Oct 23 |
| Ola Brynhildsen | MID | Out | Ola Brynhildsen is expected to return Early November 2025 from Knee injury. | Brynhildsen is out with knee | Oct 21 |
| Marin Jakolis | F | Out indefinitely | Knock | Knock | Feb 28 |
| Pablo Rosario | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Feb 11 |
| Luuk De Jong | F | Out indefinitely | Hand Injury | Hand Injury | Jun 5 |
| William Gomes | F | Doubtful | William Gomes is Doubtful with Unknown. | Gomes is doubtful with unknown | Sep 19 |
| Pepe | F | Day to day | Pepê is Day to day with Eye injury. | Pepe is day-to-day with eye | Sep 12 |
| Vasco Sousa | MID | Suspended | Vasco Sousa is serving a suspension for Red card. | Sousa is suspended with red card | Oct 27 |
| Cyrille Bayala | F | Out | Suspended | Suspended | Apr 2 |
| Yoann Cathline | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 6 |
| Davy Van Den Berg | MID | Doubtful | Davy van den Berg is Doubtful with Unknown. | Van Den Berg is doubtful with unknown | Dec 6 |
| Niklas Vesterlund | DEF | Out | Niklas Vesterlund is expected to return in About a week from Knee injury. | Vesterlund is out with knee | Nov 13 |
| Marko Arnautovic | F | Out | Foot Injury | Foot Injury | Feb 4 |
| Milos Veljkovic | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 3 |
| Nemanja Radonjic | F | Out indefinitely | None | Radonjic is injured | Jul 27 |
| Shavy Babicka | F | Out indefinitely | Shavy Babicka is Unknown with Broken leg. | Babicka is injured with leg | Dec 5 |
| Franklin Tebo | DEF | Suspended | Franklin Tebo is serving a suspension for Red card. | Tebo is suspended with red card | Nov 28 |
| Caglar Soyuncu | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 6 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Nelson Semedo | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Aug 15 |
| Fred | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Apr 28 |
| Cengiz Under | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 25 |
| Edson Alvarez | MID | Out | Suspended | Suspended | Nov 10 |
| Kerem Akturkoglu | F | Out indefinitely | Hamstring | Hamstring | Apr 10 |
| Cenk Tosun | F | Out | Cenk Tosun is expected to return Early September 2025 from Groin injury. | Tosun is out with groin | Aug 26 |
| Mert Hakan Yandas | MID | Out | Mert Hakan Yandas is expected to return Early September 2025 from Foot injury. | Yandas is out with foot | Aug 26 |
| Isaac Pappoe | MID | Out | Isaac Pappoe is expected to return Late November 2025 from Knee injury. | Pappoe is out with knee | Nov 1 |
| Cyle Larin | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 8 |
| Jordan Lotomba | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Bart Nieuwkoop | DEF | Out | Bart Nieuwkoop is expected to return Late December 2025 from Unknown. | Nieuwkoop is out with unknown | Dec 6 |
| Goncalo Borges | F | Out indefinitely | Gonçalo Borges will not play due to Personal reason. | Borges is injured with unknown | Sep 17 |
| Leo Sauer | F | Out | Leo Sauer is expected to return Late December 2025 from Unknown. | Sauer is out with unknown | Nov 30 |
| Vincenzo Grifo | MID | Out indefinitely | Virus | Virus | Apr 18 |
| Philipp Lienhart | DEF | Out | Philipp Lienhart is expected to return Early January 2026 from Groin injury. | Lienhart is out with groin | Dec 6 |
| Merlin Rohl | MID | Out | Merlin Röhl is expected to return Late December 2025 from Groin injury. | Rohl is out with groin | Dec 5 |
| Eren Dinkci | F | Out | Eren Dinkci is expected to return Mid December 2025 from Muscle injury. | Dinkci is out with muscle | Dec 5 |
| Maximilian Rosenfelder | DEF | Out | Max Rosenfelder is expected to return Early January 2026 from Hamstring Injury. | Rosenfelder is out with hamstring | Dec 6 |
| Jordy Makengo | DEF | Out | Jordy Makengo is expected to return Mid December 2025 from Muscle injury. | Makengo is out with muscle | Dec 5 |
| Cyriaque Irie | F | Out | Cyriaque Irié is expected to return in About a week from Malaria. | Irie is out with illness | Dec 5 |
| Junya Ito | MID | Out | Suspended | Suspended | Oct 16 |
| Konstantinos Karetsas | MID | Out | Konstantinos Karetsas is expected to return Early October 2025 from Back injury. | Karetsas is out with back | Sep 20 |
| Tobias Lawal | GK | Out | Tobias Lawal is expected to return in About a week from Knee injury. | Lawal is out with knee | Nov 1 |
| Yira Sor | MID | Day to day | Yira Sor is Day to day with Unknown. | Sor is day-to-day with unknown | Sep 20 |
| Olivier Giroud | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 11 |
| Nabil Bentaleb | MID | Out indefinitely | Back Injury | Back Injury | Jan 2 |
| Thomas Meunier | DEF | Out indefinitely | Back Injury | Back Injury | Apr 10 |
| Andre Gomes | MID | Out | Suspended | Suspended | Apr 2 |
| Chancel Mbemba | DEF | Out | Knee Injury | Knee Injury | Jan 13 |
| Alexsandro Ribeiro | DEF | Out | Alexsandro Ribeiro is expected to return Mid December 2025 from Thigh injury. | Ribeiro is out with thigh | Dec 5 |
| Ousmane Toure | DEF | Out indefinitely | Toure, Ousmane: missing - injured | Toure is injured | Aug 23 |
| Noah Sonko Sundberg | DEF | Out | Noah Sonko Sundberg is expected to return Late December 2025 from Hip injury. | Sonko Sundberg is out with hip | Dec 5 |
| Georgi Ilkov Terziev | DEF | Out | Georgi Terziev is expected to return Early January 2026 from Cruciate ligament injury. | Terziev is out with knee | Dec 5 |
| Edvin Kurtulus | DEF | Out | Edvin Kurtulus is expected to return Early January 2026 from Knee injury. | Kurtulus is out with knee | Dec 5 |
| Ainsley Maitland-Niles | MID | Out indefinitely | Virus | Virus | Jan 3 |
| Corentin Tolisso | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 4 |
| Orel Mangala | MID | Out indefinitely | None | Mangala is injured | Feb 13 |
| Duje Caleta-Car | DEF | Out | Virus | Virus | Aug 14 |
| Martin Satriano | F | Out indefinitely | None | Satriano is injured | Feb 13 |
| Abner Vinicius | DEF | Out indefinitely | None | Vinicius is injured | Feb 17 |
| Malick Fofana | F | Out | Malick Fofana is expected to return Late January 2026 from Ankle injury. | Fofana is out with ankle | Dec 5 |
| Ruben Kluivert | DEF | Out | Ruben Kluivert is expected to return Mid December 2025 from Sprained ankle. | Kluivert is out with ankle | Dec 5 |
| Hugo Bolin | MID | Doubtful | Hugo Bolin is Doubtful with Ankle injury. | Bolin is doubtful with ankle | Dec 6 |
| Anders Christiansen | MID | Out | Anders Christiansen is expected to return Mid November 2025 from Thigh injury. | Christiansen is out with thigh | Nov 1 |
| Johan Dahlin | GK | Doubtful | Johan Dahlin is Doubtful with Cruciate ligament injury. | Dahlin is doubtful with knee | Oct 2 |
| Otto Rosengren | MID | Doubtful | Otto Rosengren is Doubtful with Foot injury. | Rosengren is doubtful with foot | Dec 6 |
| Arnor Sigurdsson | MID | Out | Arnór Sigurdsson is expected to return Late December 2025 from Knee injury. | Sigurdsson is out with knee | Dec 6 |
| Jonathan Clauss | DEF | Out | Groin Strain | Groin Strain | Jan 24 |
| Youssouf Ndayishimiye | MID | Out indefinitely | Knock | Knock | Apr 3 |
| Mattia Viti | DEF | Out indefinitely | None | Viti is injured | Feb 13 |
| Issiaga Camara | MID | Suspended | Issiaga Camara is serving a suspension for Yellow cards. | Camara is suspended with yellow cards | Sep 29 |
| Kojo Peprah Oppong | DEF | Out | Kojo Peprah Oppong is expected to return in About 1-2 weeks from Muscle injury. | Peprah Oppong is out with muscle | Dec 5 |
| Ola Aina | DEF | Out | Ola Aina is expected to return Late December 2025 from Hamstring Injury. | Aina is out with hamstring | Dec 5 |
| Taiwo Awoniyi | F | Out | Taiwo Awoniyi is expected to return Mid December 2025 from Muscle injury. | Awoniyi is out with muscle | Dec 5 |
| Oleksandr Zinchenko | DEF | Out | Oleksandr Zinchenko is expected to return Mid December 2025 from Strain injury. | Zinchenko is out with strain | Dec 5 |
| Willy Boly | DEF | Out | Hamstring | Hamstring | Apr 11 |
| Chris Wood | F | Out | Chris Wood is expected to return Late December 2025 from Knee injury. | Wood is out with knee | Dec 5 |
| Omar Richards | DEF | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Apr 11 |
| Ryan Yates | MID | Doubtful | Ryan Yates is Doubtful with Hamstring Injury. | Yates is doubtful with hamstring | Dec 6 |
| Murillo | MID | Doubtful | Murillo is Doubtful with Calf injury. | Murillo is doubtful with calf | Dec 5 |
| Angus Gunn | GK | Out | Angus Gunn is expected to return Early January 2026 from Ligament injury. | Gunn is out with ligament | Dec 5 |
| Cuiabano | DEF | Suspended | Cuiabano is serving a suspension for Yellow cards. | Cuiabano is suspended with yellow cards | Oct 2 |
| Giulian Biancone | DEF | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Jonjoe Kenny | DEF | Out indefinitely | Concussion | Concussion | Feb 6 |
| Dejan Lovren | DEF | Out | Concussion | Concussion | Apr 11 |
| Rahman Baba | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 8 |
| Soualiho Meite | MID | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Dec 11 |
| Christos Zafeiris | MID | Suspended | Christos Zafeiris is serving a suspension for Yellow cards. | Zafeiris is suspended with yellow cards | Nov 10 |
| Renato Sanches | MID | Out | Groin/Pelvis Injury | Groin/Pelvis Injury | Mar 13 |
| Alban Lafont | GK | Out | Alban Lafont is expected to return Early January 2026 from Knee injury. | Lafont is out with knee | Dec 5 |
| Pedro Chirivella | MID | Out indefinitely | Groin Strain | Groin Strain | Apr 11 |
| Dimitris Limnios | MID | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Feb 13 |
| Erik Palmer-Brown | DEF | Out indefinitely | Knock | Knock | Dec 20 |
| Cyriel Dessers | F | Out | Cyriel Dessers is expected to return Mid September 2025 from Knee injury. | Dessers is out with knee | Aug 26 |
| Jack Butland | GK | Out indefinitely | Hand Injury | Hand Injury | Nov 7 |
| John Souttar | DEF | Out | John Souttar is expected to return Late December 2025 from Muscle injury. | Souttar is out with muscle | Dec 5 |
| Rabbi Matondo | MID | Out | Rabbi Matondo is expected to return Mid November 2025 from Unknown. | Matondo is out with unknown | Nov 1 |
| Bojan Miovski | F | Out indefinitely | None | Miovski is injured | May 24 |
| Hector Bellerin | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Oct 29 |
| Adrian | GK | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 3 |
| Pablo Fornals | MID | Out indefinitely | None | Fornals is injured | Jan 20 |
| Junior Firpo | DEF | Out | Knee Injury | Knee Injury | Sep 3 |
| Cucho Hernandez | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 22 |
| Abde Ezzalzouli | F | Out | Suspended | Suspended | Feb 12 |
| Isco | MID | Out | Isco is expected to return Mid December 2025 from Thigh injury. | Isco is out with thigh | Dec 5 |
| Angelino | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Sep 13 |
| Leon Bailey | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 15 |
| Kostas Tsimikas | DEF | Out | Knock | Knock | Aug 15 |
| Tammy Abraham | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 8 |
| Zeki Celik | DEF | Out | Suspended | Suspended | Feb 20 |
| Wesley Franca | DEF | Doubtful | Wesley is Doubtful with Physical discomfort. | Franca is doubtful with soreness | Dec 6 |
| Akim Zedadka | DEF | Doubtful | None | Zedadka is doubtful | Aug 16 |
| Stefan Lainer | DEF | Out indefinitely | Knock | Knock | Nov 11 |
| Yorbe Vertessen | F | Doubtful | Yorbe Vertessen is Doubtful with Knock injury. | Vertessen is doubtful with maintenance | Sep 12 |
| Anrie Chase | DEF | Out indefinitely | None | Chase is injured | Mar 7 |
| Alexander Schlager | GK | Doubtful | Alexander Schlager is Doubtful with Hip injury. | Schlager is doubtful with hip | Nov 9 |
| Vinicius Tobias | DEF | Doubtful | None | Tobias is doubtful | Feb 9 |
| Tigran Barseghyan | MID | Out | Tigran Barseghyan is expected to return Mid December 2025 from Groin injury. | Barseghyan is out with groin | Dec 5 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Dimitri Lavalee | DEF | Out for season | Dimitri Lavalée is Out for season with Knee injury. | Lavalee is out for season with knee | Dec 3 |
| Dan Zagadou | DEF | Out | Dan-Axel Zagadou is expected to return Late January 2026 from Tendon injury. | Zagadou is out with tendon | Dec 5 |
| Julian Chabot | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 3 |
| Ermedin Demirovic | F | Out | Suspended | Suspended | Apr 11 |
| Tiago Tomas | F | Out indefinitely | Knock | Knock | Feb 27 |
| Justin Diehl | F | Out | Justin Diehl is expected to return Mid December 2025 from Ankle injury. | Diehl is out with ankle | Dec 5 |
| Yannik Keitel | MID | Out | Yannik Keitel is expected to return Mid December 2025 from Thigh injury. | Keitel is out with thigh | Dec 5 |
| Edimilson Fernandes | DEF | Out indefinitely | Illness | Illness | Sep 19 |
| Saidy Janko | DEF | Out indefinitely | Hamstring | Hamstring | Feb 5 |
| Sergio Cordova | F | Out indefinitely | None | Cordova is injured | Mar 31 |
| Gregory Wuthrich | DEF | Doubtful | Gregory Wüthrich is Doubtful with Muscle injury. | Wuthrich is doubtful with muscle | Nov 9 |
| Loris Benito | DEF | Out indefinitely | Loris Benito is Unknown with Muscle injury. | Benito is injured with muscle | Nov 10 |
| Joel Monteiro | F | Out indefinitely | Joel Monteiro is Unknown with Knock injury. | Monteiro is injured with knock injury | Nov 24 |
| David Von Ballmoos | GK | Out indefinitely | David von Ballmoos is Unknown with Knock injury. | Von Ballmoos is injured with knock injury | Nov 21 |
| Olivier Mambwa | DEF | Out indefinitely | Olivier Mambwa will not play due to National team. | Mambwa is injured with unknown | Nov 9 |
