| Yeray Alvarez | DEF | Suspended | Yeray Álvarez is serving a suspension for Doping. | Alvarez is suspended with doping | Sep 11 |
| Alex Berenguer | F | Out | Suspended | Suspended | Feb 27 |
| Yuri Berchiche | DEF | Out | Suspended | Suspended | Feb 11 |
| Andoni Gorosabel | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 20 |
| Robert Navarro | F | Out | Robert Navarro is expected to return Mid December 2025 from Thigh injury. | Navarro is out with thigh | Dec 5 |
| Aitor Paredes | DEF | Suspended | Aitor Paredes is serving a suspension for Yellow cards. | Paredes is suspended with yellow cards | Dec 6 |
| Benat Prados | MID | Out for season | Beñat Prados is Out for season with Cruciate ligament injury. | Prados is out for season with knee | Dec 5 |
| Unai Egiluz | DEF | Out indefinitely | None | Egiluz is injured | Aug 15 |
| Maroan Sannadi | F | Out | Maroan Sannadi is expected to return Late January 2026 from Meniscus injury. | Sannadi is out with knee | Dec 5 |
| Thomas Lemar | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 27 |
| Rodrigo De Paul | MID | Out indefinitely | Hamstring | Hamstring | Mar 14 |
| Jose Maria Gimenez | DEF | Out indefinitely | Knock | Knock | Jan 30 |
| Koke | MID | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Nahuel Molina | DEF | Out | Suspended | Suspended | Sep 3 |
| Pablo Perez | DEF | Out | Pablo Pérez is expected to return Late September 2025 from Thigh injury. | Perez is out with thigh | Sep 9 |
| Ilias Kostis | DEF | Out for season | Ilias Kostis is Out for season with Cruciate ligament injury. | Kostis is out for season with knee | Dec 5 |
| Johnny Cardoso | MID | Doubtful | Johnny is Doubtful with Knee injury. | Cardoso is doubtful with knee | Dec 7 |
| Marc-Andre Ter Stegen | GK | Out indefinitely | Illness | Illness | May 10 |
| Raphinha | F | Out | Suspended | Suspended | Apr 1 |
| Ronald Araujo | DEF | Out | Ronald Araujo is expected to return Mid December 2025 from Physical discomfort. | Araujo is out with soreness | Dec 5 |
| Pedri | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Javier Ontiveros | F | Out | Shoulder Injury | Shoulder Injury | Apr 27 |
| Lucas Boye | F | Out | Suspended | Suspended | Apr 1 |
| Asier Villalibre | F | Out indefinitely | Hamstring | Hamstring | May 2 |
| Denis Suarez | MID | Doubtful | Suarez, Denis: doubtful - other | Suarez is doubtful | Aug 25 |
| Mariano Diaz | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 13 |
| Moussa Diarra | DEF | Suspended | None | Diarra is suspended | May 23 |
| Ander Guevara | MID | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Nikola Maras | DEF | Doubtful | Nikola Maras is Doubtful with Ligament injury. | Maras is doubtful with ligament | Dec 5 |
| Raul Fernandez | GK | Doubtful | None | Fernandez is doubtful | May 18 |
| Facundo Garces | DEF | Out indefinitely | Facundo Garces is serving a suspension for Police investigation. | Garces is injured with unknown | Oct 7 |
| Victor Chust | DEF | Suspended | Víctor Chust is serving a suspension for Yellow/red card. | Chust is suspended with yellow/red card | Nov 24 |
| Javi Puado | MID | Doubtful | Javi Puado is Doubtful with Knee injury. | Puado is doubtful with knee | Dec 5 |
| Jose Gragera | MID | Out | José Gragera is expected to return Mid October 2025 from Thigh injury. | Gragera is out with thigh | Sep 29 |
| Tyrhys Dolan | MID | Suspended | Tyrhys Dolan is serving a suspension for Yellow/red card. | Dolan is suspended with yellow/red card | Dec 7 |
| Luis Milla | MID | Suspended | Luis Milla is serving a suspension for Yellow cards. | Milla is suspended with yellow cards | Dec 6 |
| Davinchi | DEF | Out | David Cordón Mancha Davinchi is expected to return Mid January 2026 from Meniscus injury. | Davinchi is out with knee | Dec 5 |
| Mubarak Wakaso | MID | Out | Suspended | Suspended | Jan 18 |
| Daley Blind | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 15 |
| David Lopez | DEF | Doubtful | David Lopez is Doubtful with Thigh injury. | Lopez is doubtful with thigh | Dec 5 |
| Portu | F | Out for season | Portu is Out for season with Cruciate ligament injury. | Portu is out for season with knee | Dec 5 |
| Alex Moreno | F | Out indefinitely | Knock | Knock | Apr 4 |
| Azzedine Ounahi | MID | Doubtful | None | Ounahi is doubtful | May 14 |
| Cristhian Stuani | F | Out | Cristhian Stuani is expected to return Mid December 2025 from Muscle injury. | Stuani is out with muscle | Dec 5 |
| Mathew Ryan | GK | Out | Knee Injury | Knee Injury | Aug 28 |
| Adrian De La Fuente | DEF | Out | Adrián de la Fuente is expected to return Late December 2025 from Thigh injury. | De La Fuente is out with thigh | Dec 5 |
| Carlos Espi | F | Out | Carlos Espí is expected to return Mid December 2025 from Thigh injury. | Espi is out with thigh | Dec 5 |
| Pablo Martinez | MID | Out | Pablo Martínez is expected to return Early January 2026 from Ankle injury. | Martinez is out with ankle | Dec 5 |
| Omar Mascarell | MID | Out | Suspended | Suspended | Feb 15 |
| Sergi Darder | MID | Out | Virus | Virus | Jan 17 |
| Takuma Asano | F | Out indefinitely | Knee Injury | Knee Injury | Nov 11 |
| Pablo Maffeo | DEF | Out | Suspended | Suspended | Nov 9 |
| Martin Valjent | DEF | Out indefinitely | Back Injury | Back Injury | Apr 11 |
| Vedat Muriqi | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 28 |
| Leo Roman | GK | Out | Leo Román is expected to return Mid December 2025 from Hamstring Injury. | Roman is out with hamstring | Dec 5 |
| Antonio Raillo | DEF | Out | Antonio Raíllo is expected to return Mid January 2026 from Broken jaw. | Raillo is out with jaw | Dec 7 |
| Dani Rodriguez | MID | Out indefinitely | Dani Rodriguez is Unknown with Personal reasons. | Rodriguez is injured with personal | Dec 5 |
| M. Peybernes | DEF | Out | Suspended | Suspended | Feb 19 |
| Juanfran | DEF | Out indefinitely | Hamstring | Hamstring | Nov 26 |
| Weligton Róbson Pena de Oliveira | DEF | Out indefinitely | Knee Injury | Knee Injury | Jun 9 |
| Juan Carlos Pérez López | DEF | Out | Suspended | Suspended | Jan 5 |
| Miguel Torres Gómez | DEF | Out | Hamstring | Hamstring | May 24 |
| Sérgio Paulo Barbosa Valente | MID | Out indefinitely | Toe Injury | Toe Injury | May 22 |
| Keko | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 5 |
| Zdravko Kuzmanović | MID | Out indefinitely | Pubalgia | Pubalgia | Jun 12 |
| Jozabed | MID | Out | Suspended | Suspended | Jan 22 |
| Pablo Hervías | MID | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Apr 6 |
| Adrián | A | Out indefinitely | Knock | Knock | Jun 15 |
| Brandon Thomas Llamas | A | Out | Suspended | Suspended | Jan 3 |
| C. Gönen | GK | Out indefinitely | Shoulder Injury | Shoulder Injury | Jun 12 |
| L. Agbenyenu | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jul 17 |
| Joaquín Muñoz | A | Out | Suspended | Suspended | Mar 27 |
| P. Chavarría | A | Out indefinitely | Knock | Knock | Sep 29 |
| E. Burgos | DEF | Out | Suspended | Suspended | Feb 20 |
| M. Benkhemassa | MID | Out | Suspended | Suspended | Jan 26 |
| Caye Quintana | A | Out | Suspended | Suspended | Dec 5 |
| Jonás Ramalho | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Nov 22 |
| Genaro Rodríguez | MID | Out | Suspended | Suspended | Jan 15 |
| Lucas Torro | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 23 |
| Sergio Herrera | GK | Out indefinitely | Knee Injury | Knee Injury | Nov 9 |
| Iker Benito | F | Out for season | Iker Benito is Out for season with Cruciate ligament injury. | Benito is out for season with knee | Dec 5 |
| M. Koné | A | Out | Suspended | Suspended | Jan 12 |
| Raúl Carnero | DEF | Out | Suspended | Suspended | Mar 19 |
| Fernando Navarro i Corbacho | DEF | Out | Suspended | Suspended | Apr 1 |
| Rober | DEF | Out indefinitely | Knock | Knock | Nov 29 |
| Oscar Trejo | F | Out | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| Unai Lopez | MID | Suspended | Unai López Cabrera is serving a suspension for Yellow/red card. | Lopez is suspended with yellow/red card | Dec 7 |
| Luiz Felipe | DEF | Out indefinitely | Hamstring | Hamstring | Apr 4 |
| Pedro Diaz | MID | Out | Pedro Díaz Fanjul is expected to return Late December 2025 from Ligament injury. | Diaz is out with ligament | Dec 5 |
| Alemao | F | Doubtful | Alexandre Alemão is Doubtful with Physical discomfort. | Alemao is doubtful with soreness | Dec 5 |
| Thibaut Courtois | GK | Out indefinitely | Hamstring | Hamstring | Feb 20 |
| Antonio Rudiger | DEF | Out indefinitely | Hamstring | Hamstring | Dec 7 |
| Dani Ceballos | MID | Out indefinitely | Hamstring | Hamstring | Oct 31 |
| Dani Carvajal | DEF | Out indefinitely | Hamstring | Hamstring | Jan 30 |
| Ferland Mendy | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 11 |
| Eder Militao | DEF | Out indefinitely | Éder Militão is Unknown with Hamstring Injury. | Militao is injured with hamstring | Dec 7 |
| Rodrygo | F | Out indefinitely | None | Rodrygo is injured | May 23 |
| Aurelien Tchouameni | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 2 |
| Francisco Garcia | DEF | Suspended | Fran García is serving a suspension for Yellow/red card. | Garcia is suspended with yellow/red card | Dec 7 |
| Eric Bailly | DEF | Out | Suspended | Suspended | Feb 13 |
| Josip Brekalo | F | Out indefinitely | Illness | Illness | Jan 30 |
| Leander Dendoncker | MID | Out | Knock | Knock | Mar 12 |
| Brandon Domingues | MID | Doubtful | Brandon Dominguès is Doubtful with Physical discomfort. | Domingues is doubtful with soreness | Dec 5 |
| Santi Cazorla | MID | Suspended | Santiago Cazorla is serving a suspension for Red card. | Cazorla is suspended with red card | Dec 6 |
| Umar Sadiq | F | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Igor Zubeldia | MID | Doubtful | Igor Zubeldia is Doubtful with Muscle injury. | Zubeldia is doubtful with muscle | Dec 5 |
| Carlos Fernandez | F | Out indefinitely | None | Fernandez is injured | Jan 19 |
| Carlos Soler | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 9 |
| Goncalo Guedes | MID | Out | Knock | Knock | Apr 21 |
| Yangel Herrera | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Orri Oskarsson | F | Out indefinitely | None | Oskarsson is injured | May 3 |
| Y. Muto | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 26 |
| Matheus Pereira | MID | Out | Suspended | Suspended | Oct 30 |
| Etxeita | DEF | Out | Suspended | Suspended | Apr 23 |
| Anaitz Arbilla Zabala | DEF | Out | Suspended | Suspended | Mar 13 |
| Iván Ramis Barrios | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 24 |
| Francisco Manuel Rico Castro | MID | Out indefinitely | Knee Injury | Knee Injury | Jun 30 |
| Imanol Sarriegui Isasa | MID | Out | Hand Injury | Hand Injury | Mar 7 |
| Roberto Antonio Correa Silva | DEF | Out | Suspended | Suspended | Jan 8 |
| Paulo Oliveira | DEF | Out indefinitely | Hamstring | Hamstring | Dec 29 |
| G. Blanco | A | Out | Suspended | Suspended | Jan 10 |
| Javi Muñoz | MID | Out | Suspended | Suspended | Apr 1 |
| Enrique González Casín | A | Out indefinitely | Knock | Knock | Dec 23 |
| Peru Nolaskoain | DEF | Out | Suspended | Suspended | Jan 15 |
| Juan Berrocal | DEF | Out | Suspended | Suspended | Mar 7 |
| S. Okazaki | A | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Mikel Rico | MID | Out indefinitely | Virus | Virus | Nov 9 |
| Pablo Ínsua Blanco | DEF | Out | Suspended | Suspended | Apr 2 |
| Timor | MID | Out indefinitely | Knock | Knock | Dec 20 |
| Luisinho | DEF | Out indefinitely | Knee Injury | Knee Injury | May 22 |
| Juan Pablo Añor Acosta | MID | Out indefinitely | Hamstring | Hamstring | May 1 |
| Juan Pérez | GK | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Dec 20 |
| Cristian Salvador | MID | Out | Suspended | Suspended | Jan 9 |
| Óscar Sielva | MID | Out | Suspended | Suspended | Feb 26 |
| Gerard Valentín | DEF | Out indefinitely | Hamstring | Hamstring | Dec 26 |
| Eugeni Valderrama | MID | Out indefinitely | Hamstring | Hamstring | May 22 |
| K. Nwakali | MID | Out indefinitely | Knock | Knock | Oct 18 |
| Pedro López Muñoz | DEF | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Juan Carlos | | Out | Virus | Virus | Jan 31 |
| Pablo Martínez | MID | Out | Suspended | Suspended | Oct 31 |
| Alexis Sanchez | F | Out indefinitely | Knee Injury | Knee Injury | Apr 21 |
| Cesar Azpilicueta | DEF | Out | Head Injury | Head Injury | Apr 11 |
| Rafa Mir | F | Out indefinitely | Knock | Knock | Apr 4 |
| Lucien Agoume | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Jan 19 |
| Chidera Ejuke | F | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Batista Mendy | MID | Out | Suspended | Suspended | Feb 19 |
| Kike Salas | DEF | Out | Kike Salas is expected to return Late December 2025 from Groin injury. | Salas is out with groin | Dec 6 |
| Juanlu Juanlu | DEF | Out | Juanlu Sánchez is expected to return Late December 2025 from Muscle injury. | Juanlu is out with muscle | Dec 6 |
| Isaac Romero | F | Suspended | Isaac Romero is serving a suspension for Yellow cards. | Romero is suspended with yellow cards | Nov 30 |
| Gerard Peque | F | Suspended | Gerard Fernández Castellano Peque is serving a suspension for Yellow cards. | Peque is suspended with yellow cards | Dec 7 |
| Alejandro Bergantiños García | MID | Out | Suspended | Suspended | Mar 11 |
| Javi Fuego | MID | Out | Suspended | Suspended | Mar 26 |
| Álvaro Vázquez | A | Out | Shoulder Injury | Shoulder Injury | Sep 12 |
| Jony | MID | Out | Suspended | Suspended | Feb 12 |
| Pichu Cuéllar | GK | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Mar 1 |
| J. Babin | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 25 |
| Fernando Amorebieta Mardaras | DEF | Out indefinitely | Knock | Knock | Apr 3 |
| Pedro Díaz Fanjul | MID | Out | Suspended | Suspended | May 10 |
| Juan Rodríguez Martínez | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 1 |
| Sergio Álvarez Díaz | MID | Out | Suspended | Suspended | Feb 12 |
| José Ángel Valdés Díaz | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Aug 24 |
| Jordi Calavera Espinach | DEF | Out indefinitely | Knock | Knock | Apr 22 |
| Pablo Pérez | MID | Out | Suspended | Suspended | May 7 |
| Molinero | DEF | Out | Suspended | Suspended | Jul 6 |
| Marc Valiente | DEF | Out | Suspended | Suspended | Nov 30 |
| J. Otero | A | Out | Suspended | Suspended | Dec 14 |
| Víctor Campuzano | A | Out indefinitely | Back Injury | Back Injury | Mar 1 |
| Vasyl Kravets | DEF | Out | Suspended | Suspended | Jan 23 |
| Fran Villalba | MID | Out | Suspended | Suspended | Apr 2 |
| José Marsà | DEF | Out | Suspended | Suspended | Apr 8 |
| Luis Javier Suarez | F | Out | Suspended | Suspended | Apr 22 |
| Houboulang Mendes | DEF | Out | Knee Injury | Knee Injury | Jan 24 |
| Marko Marezi | F | Out indefinitely | Pubalgia | Pubalgia | Oct 29 |
| Mouctar Diakhaby | DEF | Doubtful | Mouctar Diakhaby is Doubtful with Hamstring Injury. | Diakhaby is doubtful with hamstring | Dec 5 |
| Dimitri Foulquier | DEF | Out indefinitely | Hamstring | Hamstring | Jan 20 |
| Thierry Correia | DEF | Out indefinitely | Hamstring | Hamstring | Feb 27 |
| Alberto Mari | F | Out indefinitely | None | Mari is injured | Aug 14 |
| Cesar Tarrega | DEF | Suspended | César Tárrega is serving a suspension for Yellow cards. | Tarrega is suspended with yellow cards | Dec 7 |
| Thomas Partey | MID | Doubtful | Thomas Partey is Doubtful with Physical discomfort. | Partey is doubtful with soreness | Dec 5 |
| Gerard Moreno | F | Out | Gerard Moreno is expected to return Late December 2025 from Muscle injury. | Moreno is out with muscle | Dec 5 |
| Ayoze Perez | F | Out indefinitely | Illness | Illness | Dec 27 |
| Juan Foyth | DEF | Out indefinitely | Knee Injury | Knee Injury | Nov 7 |
| Manor Solomon | MID | Out | Knee Injury | Knee Injury | Jan 5 |
| Santiago Mourino | DEF | Doubtful | Santiago Mouriño is Doubtful with Physical discomfort. | Mourino is doubtful with soreness | Dec 5 |
| Pau Cabanes | F | Out | Pau Cabanes is expected to return Early April 2026 from Cruciate ligament injury. | Cabanes is out with knee | Dec 5 |
Ghana
Málaga CF
RC Deportivo La Coruna
SD Eibar
SD Huesca
Sporting Gijón
