Pirates vs. Cardinals Odds & Betting Predictions - May 21, 2026

Pirates at Cardinals

5:15 pm • CARD

Pittsburgh Pirates

39-39

6 - 2

St. Louis Cardinals

42-34

pitcher		team	era	w-l
D.May			4.30	5-6
B.Ashcraft			3.18	6-3

MatchupOpenSpreadTotalMoneyline
Pirates 39-39	-1.5	-1.5+143	o7-113	-121
Cardinals 42-34	u7.5	+1.5-173	u7-108	+101

Thursday 5:15 p.m.

May 21, 2026

Busch StadiumSt. Louis

Under 9.5 (Live)-145

PIT -1.5+150

1.13u

PIT -117

PIT -116

Under 4 (F5)-130

D.May o17.5 Outs-132

1.32u

Under 0.5 (1st Inn)-138

1.38u

B.Ashcraft o5.5 Ks+127

D.May u17.5 Outs+110

0.5u

J.Walker o1.5 Total Bases+130

$1.00

O.Cruz o1.5 Hits + Runs + RBIs-105

$1.00

B.Lowe o1.5 Hits + Runs + RBIs+100

D.May u17.5 Outs+120

Under 8-115

1.15u

+15.64U L10 Days🔥📈

Under 8-115

0.58u

Bet to 7.5 (-112)

Over 7.5-112

0.5u

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No props found

MLB Public Betting

Cardinals are 2-3 in their last 5 games.
Cardinals are 1-4 in their last 5 games against the spread
Cardinals are 23-14 in their road games against the spread
The totals have gone OVER in 3 of Cardinals' last 5 games
The totals have gone OVER in 17 of Cardinals' 39 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	45-31	22-17	23-14	10-8	35-22
Pirates	39-39	18-21	21-18	21-23	17-16

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	33-39-4	17-20-2	16-19-2	7-10-1	25-29-3
Pirates	44-31-3	26-13	18-18-3	28-16	15-15-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	42-34	22-17	20-17	13-5	29-28
Pirates	39-39	20-19	19-20	24-20	14-19

date	opponent	score	spread	over/under	moneyline
May 20th	PIT	L 0-7	+1.5 L	U 7.5	PIT -117
May 19th	PIT	W 9-6	+1.5 W	O 8	STL -113
May 17th	KC	L 0-2	+1.5 L	U 9.5	KC -120
May 16th	KC	W 4-2	-1.5 W	U 9	STL -112
May 16th	KC	W 5-4	+1.5 W	O 8.5	STL -108

Oneil Cruz
CF
Oneil Cruz has been scratched Tuesday.
Out

Masyn Winn
SS
Masyn Winn (thumb) has been scratched Tuesday.
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Ashcraft, P	98	7	9	1
RW.Dotel, P	29	1	2	1
LM.Montgomery, P	8	1	0	0

HITTERS	H-AB	R	HR	RBI
1O.Cruz, CF	1-5	1	0	0
2B.Lowe, 2B	2-4	1	1	1
3B.Reynolds, LF	0-5	0	0	1
4S.Horwitz, 1B	1-3	1	0	0
5K.Griffin, SS	1-4	2	0	0
6M.Ozuna, DH	2-4	0	0	2
7J.Mangum, RF	1-4	0	0	1
8J.Triolo, 3B	1-4	0	0	0
9H.Davis, C	1-3	1	1	1

PITCHER	PC	IP	K	ER
RD.May, P	91	5.1	7	4
RG.Graceffo, P	2	0.2	0	0
LJ.Bruihl, P	16	0.2	0	2
RM.Svanson, P	19	1.1	1	0
RM.Pushard, P	7	1	1	0

HITTERS	H-AB	R	HR	RBI
1J.Wetherholt, 2B	0-4	0	0	0
2I.Herrera, DH	2-4	2	1	1
3A.Burleson, 1B	2-4	0	0	0
4J.Walker, RF	1-4	0	0	1
5N.Gorman, 3B	0-4	0	0	0
6M.Winn, SS	0-2	0	0	0
7J.Fermin, LF	1-4	0	0	0
8P.Pages, C	2-4	0	0	0
9V.Scott, CF	0-3	0	0	0
9Y.Pozo, PH	0-1	0	0	0