The Cleveland Guardians host the Cincinnati Reds on May 17, 2026. First pitch from Progressive Field is scheduled for 1:40 p.m. EDT. The game will be broadcast on CINR.
The Guardians are favored by -164 on the moneyline and by -1.5 on the run line. The Reds are +138 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs (-110 / -110).
Find my MLB picks and Reds vs Guardians prediction below, as well as probable pitchers, weather report, and more.
Reds vs Guardians Prediction
Reds vs Guardians Picks:
- Jose Ramirez Over 1.5 Total Bases (-105)
- Jose Ramirez Over 0.5 Home Runs (+350)
Reds vs Guardians Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -160 | 8.5 -110o / -110u | +138 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +132 | 8.5 -110o / -110u | -164 |
Reds vs Guardians Probable Pitchers
| Brady Singer (RHP, CIN) | Stat | Gavin Williams (RHP, CLE) |
|---|---|---|
| 2-3 | W-L | 5-3 |
| -0.2 | fWAR (FanGraphs) | 0.8 |
| 5.79 / 6.02 | ERA / xERA | 3.74 / 4.34 |
| 6.17 / 4.60 | FIP / xFIP | 3.84 / 3.23 |
| 8.7% | K-BB% | 19.6% |
| 41.2% | GB% | 45.9% |
| .336 | BABIP | .273 |
| 91 | Stuff+ | 105 |
| 99 | Location+ | 101 |
Reds vs Guardians MLB Betting Preview
Brady Singer has been brutal. He’s running a 5.79 ERA and 1.67 WHIP across his first five outings.
Given his stint in Kansas City, he’s faced this Guardians lineup plenty of times. He has a real history with Jose Ramirez.
In 29 career head-to-head at-bats, Ramirez has bashed 12 hits, including three homers.
Ramirez hasn’t been elite to start the season, but he should round into form eventually. His expected wOBA (.372) is nearly 50 points higher than his actual (.325), and he’s been unlucky with BABIP variance (.230).
Reds vs Guardians Pick, Betting Analysis
This is a great spot for J-Ram to right the ship against a pitcher he loves facing.
Picks:
- Jose Ramirez Over 1.5 Total Bases (-105)
- Jose Ramirez Over 0.5 Home Runs (+350)
