The San Francisco Giants host the Los Angeles Dodgers on April 21, 2026. First pitch from Oracle Park is scheduled for 9:45 p.m. EDT. The game will be broadcast on SportsNet LA.
The Dodgers are favored by -180 on the moneyline and by -1.5 on the run line. The Giants are +152 on the moneyline and +1.5 on the run line. The total is set at 7 runs.
Find my MLB picks and Dodgers vs Giants prediction below, as well as probable pitchers, weather report, and more.
Dodgers vs Giants Predictions, Pick
- Dodgers vs Giants Pick: Giants Moneyline
My Dodgers vs Giants best bet is on San Francisco to win. Make sure to find the best odds by checking our live MLB odds page.
Dodgers vs Giants Odds, Run Line, and Total
| Dodgers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -105 | 7.5 -100o / -122u | -180 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -114 | 7.5 -100o / -122u | +152 |
- Dodgers vs Giants moneyline: Dodgers -180, Giants +152
- Dodgers vs Giants over/under: 7.5 (-100o / -122u)
- Dodgers vs Giants spread: Dodgers -1.5 (-105), Giants +1.5 (-114)
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Dodgers vs Giants Pitchers
| Yoshinobu Yamamoto | Stat | Landen Roupp |
|---|---|---|
| 15-4 | W-L | 8-12 |
| 0.5 | fWAR (FanGraphs) | 0.7 |
| 2.10 / 3.49 | ERA / xERA | 2.38 / 2.56 |
| 3.48 / 3.51 | FIP / xFIP | 2.21 / 3.11 |
| 0.82 | WHIP | 0.97 |
| 18.9 | K-BB% | 18.9 |
| 42.6 | GB% | 50.9 |
| 100 | Stuff+ | 100 |
| 105 | Location+ | 101 |
Dodgers vs Giants MLB Betting Preview
Los Angeles Dodgers Trends, Key Players
The Dodgers still lead the NL West and have the best record in baseball with several early highlights. 2025 signing Tanner Scott is finding his form, Max Muncy is playing like Kyle Schwarber, and Dalton Rushing is one of the league's HR leaders despite playing just eight games!
Nevertheless, the Dodgers are coming off a weird weekend in Colorado. They split this four-game series against the perennial bottom-feeder but dominated the final game 12-3. The team is in a gray area with their roster.
Mookie Betts (oblique) is still hurt, Edwin Diaz (elbow) is out until after the All-Star break, and their big offseason signing, Kyle Tucker, is treading water. Also, they are still in the "test run" phase with Roki Sasaki.
There is plenty of confidence that this team should still contend for another World Series, but they are not firing on all cylinders yet. If you see their +190 odds to win this year's championship jump to the mid-200s at any point, jump on that line.
San Francisco Giants Trends, Key Players
The Giants have won three of their past four games and could be finding their form.
However, there are still several question marks. They do not have a set closer after Ryan Walker's early-season struggles, Logan Webb is getting shelled, and the offense is better, but not good enough.
The biggest question mark thus far is Rafael Devers. Their marquee midseason trade last year is not paying any dividends. He has a negative 0.5 fWAR and a 62 wRC+ through 22 games. Fortunately, the star corner infielder is no stranger to first-month struggles.
From March 27 through April 24 last year, Devers posted an 82 wRC+ with a .194/.331/.327 slash line in 121 plate appearances.
Devers' strikeout rate thus far in 94 PAs is similar to his 2025 rate, and his .225/.266/.315 slash line this year is not a far cry from that early 2025 line. However, there is a reasonable concern over his current 5.3% walk rate. This is much lower than his career 9.4% rate, but luckily, it is still early.
Devers' track record is long enough to believe it will self-correct shortly. Giants fans and bettors should keep the faith that he will get on track.
Also, their aforementioned bullpen will figure out the closer situation in-house. Cole Winn and Caleb Killian are experiencing significant breakouts this season and should be in the mix for the ninth inning soon.
How To Bet My Dodgers vs Giants Pick, Betting Analysis
If you just looked at each team's respective starting pitcher by name, it would be obvious to lean toward the side with Yoshinobu Yamamoto. He is a historically great Japanese SP, who was one of the five best pitchers in baseball last season, and the best in the postseason.
Nevertheless, Landen Roupp is having a better start to 2026. Roupp is not a household name like Yamamoto, nor is he getting paid anywhere near the same salary, but he can pitch. The Giants' starter has a better xFIP and SIERA than Yamamoto, while his xERA is a full run lower!
The Giants are also benefiting from a day off in between their Sunday game and Tuesday's matchup. Meanwhile, the Dodgers played in Colorado on Monday night. Typically, teams traveling immediately after a series in Coors suffer the impact of a stark altitude change.
The Dodgers' lineup may be missing Freddie Freeman for a third consecutive day, as he has not been activated from the paternity list yet. Freeman can spend up to three days on the list, and if he is out, that would equate to a Dodgers lineup without him or the injured Mookie Betts.
With the Giants slowly righting their ship and the Dodgers losing two of their last three against the lowly Rockies, this game at solid plus money is a good opportunity to be contrarian.
Pick: Giants Moneyline
