The Detroit Tigers (12-12) host the Milwaukee Brewers (13-9) on April 22, 2026. First pitch from Comerica Park is scheduled for 6:40 p.m. EDT. The game will be broadcast on BREW.
The Tigers are favored by -134 on the moneyline and by -1.5 (+152) on the run line. The Brewers are +116 on the moneyline and +1.5 (-184) on the run line. The total is set at 7.5 runs (-124 / +102).
Find my MLB picks and Brewers vs Tigers prediction below, as well as probable pitchers, weather report, and more.
Brewers vs Tigers Predictions, Pick
- Brewers vs Tigers Pick: Brewers ML (+110 or Better)
My Brewers vs Tigers best bet is on Milwaukee to win. Make sure to find the best odds by checking our live MLB odds page.
Brewers vs Tigers Odds, Run Line, Over/Under
| Brewers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -184 | 7.5 -124o / 102u | +116 |
| Tigers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +152 | 7.5 -124o / 102u | -134 |
- Brewers vs Tigers moneyline: Brewers +116, Tigers -134
- Brewers vs Tigers over/under: 7.5 (-124o / +102u)
- Brewers vs Tigers spread: Tigers -1.5 (+152), Brewers +1.5 (-184)
Brewers vs Tigers Probable Pitchers
| Chad Patrick (RHP, MIL) | Stat | Casey Mize (RHP, DET) |
|---|---|---|
| 1-0 | W-L | 1-1 |
| 0.2 | fWAR (FanGraphs) | 0.6 |
| 0.95 / 3.06 | ERA / xERA | 2.78 / 3.62 |
| 3.98 / 5.39 | FIP / xFIP | 3.14 / 3.75 |
| 2.7% | K-BB% | 19.1% |
| 37.3% | GB% | 34.4% |
| .241 | BABIP | .305 |
| 95 | Stuff+ | 89 |
| 97 | Location+ | 100 |
Brewers vs Tigers Expert MLB Pick
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
In Major League Baseball, road underdogs playing interleague games have historically been undervalued by oddsmakers.
Since 2016, despite winning only 43% of these games, these teams have generated a consistent positive ROI.
This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced — likely due to lack of familiarity between leagues and public overconfidence in home and favorite teams.
How To Bet My Brewers vs Tigers Pick, Betting Analysis
Although Casey Mize is a much better starting pitcher than Chad Patrick, I don’t think it’s enough to compensate for the other areas of the game.
Specifically, my numbers project Milwaukee as the much better defensive and base-running team.
Hence why I show value on the Brew Crew as road pups in this interleague matchup.
Pick: Brewers ML (+110 or Better)
