We have a 15-game slate on Wednesday, starting with Blue Jays vs. Rays at 1:10 p.m. ET, which gives us plenty of early options for some bangers.
Read on for my Home Run Picks Today for Wednesday, May 6.
MLB Home Run Picks Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:10 PM | |
  | 4:07 PM | |
  | 6:40 PM | |
  | 7:05 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Editor's Note: A home run parlay is not the author's formal recommendation. These home run picks have value as straight bets.
Blue Jays vs Rays HR Pick
The odds are way off for Junior Caminero today, given the spot.
The Rays third baseman is one of the best hitters in the league, and the matchup against Patrick Corbin is well above average for righty power.
I have the true odds on Caminero around +300, making this a great EV bet.
Pick: Junior Caminero Home Run
| | | |
White Sox vs Angels Player Prop
Miguel Vargas has been great so far this season, and he comes into this game in good form.
Angels SP Walbert Urena really doesn't have much of an out pitch for righties, and while we don't have a ton of data on him in the majors, he should be a reverse-splits pitcher when it comes to power.
I have the true odds on the White Sox 3B around +450.
Pick: Miguel Vargas Home Run
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Athletics vs Phillies HR Prop
Nick Kurtz is one of the best home run hitters in the league, and the odds are too high here.
While Zack Wheeler is still one of the best pitchers in the league, he's been very susceptible to lefty power over the last few seasons, allowing around a 1.3 HR/9.
Philly is one of the more wind-receptive ballparks in the league, and with the wind blowing out at 10 mph, the ball should be flying.
I have the true odds on the Athletics 1B around +325 today, making this a great EV bet.
Pick: Nick Kurtz Home Run
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Rangers vs Yankees Prop Pick
The weather is a slight issue here, but I think the game plays clean.
Rangers SP Nathan Eovaldi was one of the best pitchers in the league in 2025, but he was due for massive regression, and it's come hard this season.
He grades out as a plus matchup for lefty power, and I have the true odds around +350 on Trent Grisham tonight.
Pick: Trent Grisham Home Run
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