With a loaded 15-game slate for Tuesday, April 22, I have four MLB home run props to target tonight.
Tonight, I'm targeting Guardians slugger Jose Ramirez and a trio of AL West stars in Cal Raleigh, Mike Trout and Wyatt Langford.
Find my MLB home run prop bets and picks for Tuesday night below.
Note: A parlay of these home run picks is not the author's formal recommendation. These are recommended as smaller straight bets that are explained in detail below.
MLB Home Run Props, Picks, Odds Today — 4/22
Time (ET) | Player Prop |
---|---|
6:10 p.m. | |
6:45 p.m. | |
9:38 p.m. | |
10:05 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. |
MLB Home Run Picks for April 22

Jose Ramirez Home Run (+560)
vs. Yankees (SP: RHP Will Warren)

We don't have a big sample size of Yankees starting pitcher Will Warren in the majors, but he's been a plus matchup for HRs and grades out as an above-average matchup for left-handed power hitters.
The weather in Cleveland isn't great for hitting, but these odds are more than enough to make up for it.
Jose Ramirez is one of the best HR hitters in the league — he had 39 homers last season and he has five homers already this season.
Progressive Field is a plus ballpark for lefty power, and I have the true odds here nearly 100 points lower.

Cal Raleigh Home Run (+375)
@ Red Sox (SP: RHP Brayan Bello)

Cal Raleigh has been the hottest hitter in MLB this season, and he's not in a bad spot tonight.
The weather in Boston should be sitting around 70 degrees with the wind blowing out to right field at 11 mph, which should help out left-handed hitters.
Red Sox starting pitcher Brayan Bello, who is making his season debut tonight, has been susceptible to lefty power in his career, giving up 1.35 HR/9 to go along with bad fly-ball and hard-contact numbers.
I have the true odds here around +300.

Mike Trout Home Run (+400)
vs. Pirates (SP: LHP Bailey Falter)

I have no idea what the books are thinking pricing Mike Trout like this against a left-handed pitcher, but I'm going to take advantage.
Trout has been hitting bombs at a massive clip this season as eight of his 14 hits this season have been home runs.
The barrel rate is the best of his career, and Pirates starting pitcher Bailey Falter is an above-average matchup for righty power.
I'm not overthinking this and taking the big discount.

Wyatt Langford Home Run (+500)
@ Athletics (SP: RHP Osvaldo Bido)

Budding star Wyatt Langford is off to a good start this season with four HRs in 13 games.
He should be around a 30-35 HR hitter this season if he can stay healthy, and he's in a great spot tonight.
The matchup on paper against Athletics starter Osvaldo Bido may not seem like a great one, but Bido's career 0.53 HR/9 is due for some massive regression as he owns a razor-thin 4.7% HR/FB, which has to regress at some point soon.
Sutter Health Park is one of the best in the league for power, and the weather should be good, with temps in the mid-70s and winds blowing out at 7 mph.
I have the true odds here 100 points lower.