MLB Picks Tonight: Late Slate Home Run Predictions, Parlay

MLB Picks Tonight: Late Slate Home Run Predictions, Parlay article feature image
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May 1, 2025; Toronto, Ontario, CAN; Toronto Blue Jays first baseman Vladimir Guerrero Jr. (27) is doused with sports drink by team mates as they celebrate a win. Credit: Dan Hamilton-Imagn Images

I'm back with another round of home run parlays, this time focusing on the MLB night slate.

With two power-packed picks lined up, I'm diving into the matchups between the Orioles and Twins, as well as the Blue Jays and Orioles.

Tonight's home run picks boast straight odds of +500 and +600. When combined, they present an enticing parlay opportunity at +4100 on bet365.

Here's who I'm banking on to launch one out of the park in the night slate, utilizing our predictive MLB models.

MLB Picks Tonight: Late Slate Home Run Predictions, Parlay

As these models crunch the numbers and analyze key factors, they highlight certain hitters as prime candidates worth backing for a home run.

These two players, in fact, are PRO Projections' top two edges for the entire May 7 slate.

Home Run Pick for Wednesday: