The San Diego Padres host the Philadelphia Phillies on May 25, 2026. First pitch from Petco Park is scheduled for 6:40 p.m. EDT. The game will be broadcast on NBCS-PH.
The Phillies are favored by -130 on the moneyline and by -1.5 on the run line. The Padres are +110 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Phillies vs Padres prediction below, as well as probable pitchers, weather report, and more.
Phillies vs Padres Prediction
- Phillies vs Padres Pick: Schwarber Homer (+265), Phillies Moneyline (-130)
My Phillies vs Padres best bets are on Schwarber to hit a homer and Philadelphia to win outright. Make sure to find the best odds by checking our live MLB odds page.
Phillies vs Padres Odds
| Phillies Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +130 | 7.5 -100o / -122u | -130 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -156 | 7.5 -100o / -122u | +110 |
- Phillies vs Padres moneyline: Phillies -130, Padres +105
- Phillies vs Padres over/under: 7.5 (-100o / -122u)
- Phillies vs Padres spread: Phillies -1.5 (+130), Padres +1.5 (-156)
Phillies vs Padres Probable Pitchers
| LHP Jesus Luzardo (PHI) | Stat | RHP Randy Vasquez (SDP) |
|---|---|---|
| 3-4 | W-L | 5-2 |
| 1.5 | fWAR (FanGraphs) | 0.8 |
| 4.85/3.21 | ERA / xERA | 2.96/5.43 |
| 2.85/2.68 | FIP / xFIP | 3.67/4.18 |
| 21.6% | K-BB% | 12.9% |
| 47.7% | GB% | 38.6% |
| .361 | BABIP | .284 |
| 110 | Stuff+ | 99 |
| 101 | Location+ | 101 |
Phillies vs Padres MLB Betting Preview
The Phillies had to travel across the country to San Diego for this game. But they get greeted by a series opener against Randy Vasquez.
Vasquez is a right-handed pitcher with a mid-90s fastball and not much else going for him.
The Phillies are popping in my matchups model big-time. Kyle Schwarber, Bryce Harper, and Brandon Marsh all have historically crushed the type of pitches that Vasquez throws, and that narrows it down to the specific movement profiles of the pitches.
So I like the Phillies for some loud contact and run scoring today.
They're only -130 on the moneyline behind Jesus Luzardo, so that's pretty appealing.
The travel and the fact that Luzardo isn't consistent makes you pause a little bit there. But I feel good about it.
Let's go with a Schwarber bomb and a Phillies win.
Picks: Schwarber Homer (+265), Phillies Moneyline (-130)
