| E. Hyndman | MID | Out indefinitely | Broken Leg | Broken Leg | Aug 27 |
| B. Lennon | DEF | Out | Brooks Lennon is expected to return Late December 2025 from Achilles tendon injury. | Lennon is out with achilles | Oct 5 |
| E. Rigoni | A | Out | Hamstring | Hamstring | Mar 17 |
| Bojan | A | Out indefinitely | Hamstring | Hamstring | Oct 16 |
| V. Wanyama | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 29 |
| Doneil Henry | DEF | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Feb 25 |
| C. Fuchs | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Sep 14 |
| Bastian Schweinsteiger | MID | Out indefinitely | Knock | Knock | Oct 13 |
| R. Berič | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 2 |
| N. Gaitán | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Sep 11 |
| Álvaro Medrán Just | MID | Out indefinitely | Back Injury | Back Injury | May 3 |
| Christopher Matthew Mueller | MID | Out | None | Mueller is out | May 9 |
| V. Bezerra | A | Out indefinitely | None | Bezerra is injured | Aug 25 |
| S. Nicholson | MID | Out indefinitely | None | Nicholson is injured | Oct 21 |
| Jack Price | midfielder | Out indefinitely | None | Price is injured | Aug 25 |
| B. Smith | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Jan 12 |
| C. Benteke | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| W. Rooney | A | Out indefinitely | Knee Injury | Knee Injury | May 28 |
| G. Cameron | DEF | Out | Concussion | Concussion | Dec 1 |
| M. Deplagne | DEF | Out indefinitely | Knock | Knock | Jun 4 |
| S. de Jong | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| C. Stanko | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 16 |
| F. Quignón | MID | Doubtful | None | Quignon is doubtful | Nov 10 |
| D. Steres | DEF | Out | Daniel Steres is expected to return Early November 2025 from Muscle injury. | Steres is out with muscle | Oct 18 |
| A. Tarbell | GK | Out indefinitely | None | Tarbell is injured | Mar 22 |
| F. Escobar | DEF | Out | Franco Escobar is expected to return Early November 2025 from Illness. | Escobar is out with illness | Oct 18 |
| Ifunanyachi Achara | A | Out indefinitely | None | Achara is injured | Aug 25 |
| Douglas Costa | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Feb 10 |
| R. Alessandrini | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 6 |
| N. DePuy | DEF | Out indefinitely | None | DePuy is injured | Aug 25 |
| Jonathan Perez | midfielder | Out | Jonathan Pérez is expected to return Early November 2025 from Thigh injury. | Perez is out with thigh | Oct 18 |
| Vadim Demidov | DEF | Out indefinitely | Hamstring | Hamstring | Mar 9 |
| Brou Benjamin Angoua | DEF | Out indefinitely | Knock | Knock | Mar 19 |
| Wilfrid Jaures Kaptoum | MID | Out indefinitely | Hamstring | Hamstring | Oct 27 |
| F. Kessler | DEF | Out | Henry Kessler is expected to return Early November 2025 from Muscle injury. | Kessler is out with muscle | Oct 18 |
| DeJuan Jones | defender | Out | DeJuan Jones is expected to return Early November 2025 from Muscle injury. | Jones is out with muscle | Oct 18 |
| K. Parks | MID | Out | Keaton Parks is expected to return Early November 2025 from Leg injury. | Parks is out with leg | Oct 18 |
| W. Cartagena | MID | Out | None | Cartagena is out | Aug 10 |
| Sergio Santos | A | Out | Sergio Santos is expected to return Early November 2025 from Muscle injury. | Santos is out with muscle | Oct 18 |
| Bobby Shou Wood | A | Out indefinitely | Knee Injury | Knee Injury | Jun 10 |
| Z. MacMath | GK | Out indefinitely | MacMath, Zac: missing - injured | MacMath is injured | Aug 20 |
| Stephen Obayan Sunday | MID | Out indefinitely | Suspended | Suspended | Feb 24 |
| M. López | DEF | Out indefinitely | Knock | Knock | Aug 28 |
| R. Walter | MID | Out | Ankle Ligaments | Ankle Ligaments | Oct 14 |
| Diego Iván Rubio Kostner | A | Out | Diego Rubio is expected to return Mid November 2025 from Hamstring Injury. | Rubio is out with hamstring | Oct 18 |
| N. Radoja | MID | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| N. Isimat-Mirin | DEF | Out | Knee Injury | Knee Injury | Feb 15 |
| K. Ford | DEF | Out indefinitely | None | Ford is injured | Aug 25 |
| C. Salcedo | DEF | Out | Foot Injury | Foot Injury | Nov 29 |
| Diego Rossi | A | Doubtful | Diego Rossi is Doubtful with Thigh injury. | Rossi is doubtful with thigh | Oct 20 |
| Russell Teibert | MID | Out indefinitely | None | Teibert is injured | Aug 25 |
| A. Cubas | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 4 |
| Brian White | forward | Out | Brian White is expected to return Early November 2025 from Hamstring Injury. | White is out with hamstring | Oct 5 |
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