| E. Hyndman | MID | Out indefinitely | Broken Leg | Broken Leg | Aug 27 |
| A. Kann | GK | Out indefinitely | None | Kann is injured | Jul 20 |
| B. Lennon | DEF | Out indefinitely | None | Lennon is injured | Nov 2 |
| E. Rigoni | A | Out | Hamstring | Hamstring | Mar 17 |
| Bojan | A | Out indefinitely | Hamstring | Hamstring | Oct 16 |
| V. Wanyama | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 29 |
| Maximiliano Urruti | A | Doubtful | None | Urruti is doubtful | Oct 6 |
| K. Miller | DEF | Suspended | None | Miller is suspended | Oct 19 |
| Doneil Henry | DEF | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Feb 25 |
| C. Fuchs | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Sep 14 |
| Bastian Schweinsteiger | MID | Out indefinitely | Knock | Knock | Oct 13 |
| R. Berič | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 2 |
| Fabian Herbers | MID | Doubtful | None | Herbers is doubtful | Oct 19 |
| N. Gaitán | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Sep 11 |
| Álvaro Medrán Just | MID | Out indefinitely | Back Injury | Back Injury | May 3 |
| V. Bezerra | A | Out indefinitely | None | Bezerra is injured | Dec 1 |
| S. Nicholson | MID | Out indefinitely | None | Nicholson is injured | Oct 21 |
| Juan Camilo Hernández Suárez | A | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 22 |
| B. Smith | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Jan 12 |
| C. Benteke | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| W. Rooney | A | Out indefinitely | Knee Injury | Knee Injury | May 28 |
| C. Durkin | MID | Doubtful | None | Durkin is doubtful | Sep 28 |
| Pedro Santos | MID | Out | None | Santos is out | Oct 21 |
| Ruan | DEF | Doubtful | None | Ruan is doubtful | Oct 19 |
| J. Hopkins | MID | Out indefinitely | None | Hopkins is injured | Aug 24 |
| G. Cameron | DEF | Out | Concussion | Concussion | Dec 1 |
| M. Deplagne | DEF | Out indefinitely | Knock | Knock | Jun 4 |
| S. de Jong | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| C. Stanko | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 16 |
| Paxton Pomykal | MID | Out indefinitely | None | Pomykal is injured | May 24 |
| F. Quignón | MID | Doubtful | None | Quignon is doubtful | Nov 10 |
| F. Escobar | DEF | Suspended | None | Escobar is suspended | Oct 19 |
| Adalberto Eliécer Carrasquilla Alcázar | MID | Out | None | Carrasquilla is out | Nov 3 |
| N. Quiñónes | A | Out indefinitely | None | Quinones is injured | Jun 18 |
| K. Gibbs | DEF | Out | Back Injury | Back Injury | Feb 27 |
| Blaise Matuidi | MID | Out indefinitely | Groin Strain | Groin Strain | Mar 20 |
| Kelvin Walther Gianini Leerdam | DEF | Out indefinitely | Knee Injury | Knee Injury | May 1 |
| I. Fray | DEF | Out indefinitely | None | Fray is injured | Nov 2 |
| Douglas Costa | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Feb 10 |
| R. Alessandrini | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 6 |
| M. Delgado | MID | Out | None | Delgado is out | Oct 19 |
| N. DePuy | DEF | Out indefinitely | None | DePuy is injured | Sep 23 |
| Tello | A | Out indefinitely | Knock | Knock | Apr 4 |
| D. Bouanga | A | Out | Suspended | Suspended | Jan 4 |
| K. Vermeer | GK | Out indefinitely | Knock | Knock | Dec 16 |
| Danny Musovski | A | Out indefinitely | None | Musovski is injured | Nov 3 |
| Vadim Demidov | DEF | Out indefinitely | Hamstring | Hamstring | Mar 9 |
| W. Omsberg | DEF | Doubtful | None | Omsberg is doubtful | Oct 19 |
| F. Fragapane | A | Out indefinitely | None | Fragapane is injured | Nov 24 |
| T. Bunbury | A | Doubtful | None | Bunbury is doubtful | Oct 19 |
| Brou Benjamin Angoua | DEF | Out indefinitely | Knock | Knock | Mar 19 |
| Wilfrid Jaures Kaptoum | MID | Out indefinitely | Hamstring | Hamstring | Oct 27 |
| Damian Rivera | midfielder | Out indefinitely | None | Rivera is injured | Dec 1 |
| M. Stajduhar | GK | Out indefinitely | None | Stajduhar is injured | Jul 4 |
| Zac McGraw | defender | Out | None | McGraw is out | Oct 19 |
| Bobby Shou Wood | A | Out indefinitely | Knee Injury | Knee Injury | Jun 10 |
| Stephen Obayan Sunday | MID | Out indefinitely | Suspended | Suspended | Feb 24 |
| M. López | DEF | Out indefinitely | Knock | Knock | Aug 28 |
| B. Kikanovic | A | Out indefinitely | None | Kikanovic is injured | Sep 18 |
| Michael Robert Baldisimo | MID | Out indefinitely | None | Baldisimo is injured | Sep 14 |
| Víctor Rodríguez Romero | MID | Out indefinitely | Knock | Knock | Feb 28 |
| Yeimar Pastor Gómez Andrade | DEF | Doubtful | None | Gomez Andrade is doubtful | Nov 30 |
| R. Walter | MID | Out | Ankle Ligaments | Ankle Ligaments | Oct 14 |
| N. Radoja | MID | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| N. Isimat-Mirin | DEF | Out | Knee Injury | Knee Injury | Feb 15 |
| Johnny Russell | A | Out indefinitely | None | Russell is injured | Oct 19 |
| C. Salcedo | DEF | Out | Foot Injury | Foot Injury | Nov 29 |
| N. Hagglund | DEF | Out indefinitely | None | Hagglund is injured | Aug 24 |
| Q. Westberg | GK | Out indefinitely | None | Westberg is injured | Nov 9 |
| Russell Teibert | MID | Out indefinitely | None | Teibert is injured | Nov 4 |
| A. Cubas | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 4 |
| Ryan Raposo | midfielder | Doubtful | None | Raposo is doubtful | Nov 8 |
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