The No. 1 Duke Blue Devils (25-2) take on the Notre Dame Fighting Irish (12-15) in South Bend, Indiana. Tip-off is set for 7 p.m. ET on ESPN.
Duke is favored by 17.5 points on the spread with a moneyline of -2800. The total is set at 139.5 points.
Here’s my Duke vs. Notre Dame predictions and college basketball picks for February 24, 2026.
Duke vs Notre Dame Predictions
My Pick: Duke -17.5
My Duke vs Notre Dame best bet is on the Blue Devils to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Duke vs. Notre Dame Odds
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-17.5 -110 | 140 -110o / -110u | -2000 |
| Notre Dame Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+17.5 -110 | 140 -110o / -110u | +1000 |
- Duke vs Notre Dame spread: Duke -17.5
- Duke vs Notre Dame over/under: 140 points
- Duke vs Notre Dame moneyline: Duke -2000, Notre Dame +1000
Duke vs Notre Dame Picks, Predictions for Tonight's College Basketball Game
Duke Blue Devils Betting Trends
Duke is coming off its best win of the season (No. 1 Michigan) and now sits at 25-2 overall and 13-1 in the ACC.
The main storyline for Duke is its elite defense. The guards have done an outstanding job this season when it comes to pressuring the ball handler, while the bigs create difficult shot opportunities around the rim.
In the Blue Devils' last 11 games, they're the top defense in the country, via Bart Torvik, and are holding opponents to 58.8 points per game.
Jon Scheyer has done a tremendous job of tweaking his defense and having Dame Sarr guard the point of attack recently. On the season, Sarr is holding opponents to 38-of-126 (30.2%) shooting with a 17.1% turnover rate.
Overall, opponents are averaging 0.826 points per possession against Duke, which ranks in the 98th percentile.
Offensively, Duke has proven to win against the best frontcourts in the country. Cam Boozer is coming off an 18/10/7 stat line against Michigan, while Patrick Ngongba II and Maliq Brown have been excellent all season.
Notre Dame Fighting Irish Betting Trends
Notre Dame comes into this game at 12-15 overall and 3-11 in conference and is fresh off a tough loss to a bad Pittsburgh team.
The Irish lost Markus Burton for the season back on December 5 and there's a good chance their current leading scorer — Jalen Haralson — is out against Duke, as well.
Notre Dame's senior forward Carson Towt made the news on Monday for signing with JB Sports to pursue an NFL career, and that sums up the season it's been for the Fighting Irish.
Towt has been a solid piece, averaging 6.4 points and 9.4 rebounds per game while having the best offensive rebounding percentage in the ACC.
If there's any chance of an upset, Towt will have to have his best rebounding performance against Duke's talented frontcourt.
How To Bet My Duke vs. Notre Dame Pick for Tonight
Though Duke is coming off an emotional win, I don't see a letdown spot here.
Duke's defense has been the best defense in the country since mid-January, and it'll lean on Sarr's consistent ball pressure to make a short-handed Notre Dame team struggle to score the basketball without its two leading scorers.
On the offensive side of the ball, Duke will continue to run its stuff thru its big men at the top of the key, with an emphasis on going high-low against a smaller Notre Dame defense that gives up 57.1% on 2-pointers this season.
My Pick: Duke -17.5
