The Ohio Bobcats take on the Louisville Cardinals in Louisville, KY. Tip-off is set for 12 p.m. ET on The CW Network.
Louisville is favored by -30 points on the spread, and the total is set at 174.5 points.
Here are my Ohio vs. Louisville predictions and college basketball picks for November 15, 2025.
Ohio vs Louisville Prediction
My Pick: Ohio +30.5
My Ohio vs Louisville best bet is on the Bobcats to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Ohio vs. Louisville Odds
| Ohio Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+30 -105 | 174.5 -115o / -105u | OFF |
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-30 -115 | 174.5 -115o / -105u | OFF |
- Ohio vs Louisville spread: Louisville -30
- Ohio vs Louisville over/under: 174.5 points
Ohio vs Louisville College Basketball Betting Preview
Ohio is coming off a blowout loss to Saint Mary's, and now hits the road to Louisville with a massive opportunity to get right. The Bobcats have a dynamic duo in the backcourt of Jackson Paveletzke and Aidan Hadaway, who have combined to average 33 points per game this season and pose trouble for any opposition.
That leads us to Louisville, which has been torching nets early this season. The Cardinals are averaging 102 points per game, including a recent 96-point outburst against No. 9-ranked Kentucky.
So, will the Bobcats cover this big spread on the road? Our Evan Abrams has a system — "Betting The Bad" — that says they will, despite their recent loss and 1-2 ATS mark.
In college basketball, teams that have struggled against the spread and are coming off a decisive loss often become undervalued by the market, particularly when facing large double-digit spreads.
After repeated poor performances, oddsmakers tend to overadjust, creating opportunities for motivated teams to outperform expectations even without winning outright.
The combination of public bias against losing teams and the natural tendency for effort and variance to stabilize makes these spots profitable over time.
By backing teams that appear to be playing poorly but are priced at their lowest point, this system identifies where perception has drifted too far from performance reality, leading to consistent value against inflated lines.
So, the value lies on Ohio +30.5, and this system has a crisp 10-4 record this season with a 37% return on investment.
My Pick: Ohio +30.5
