Nicholls St vs. SE Louisiana Odds & Betting Predictions - November 21, 2025

Nicholls St at SE Louisiana

12:00 am • ESPN+

Nicholls State Colonels

@

Southeastern Louisiana Lions

MatchupOpenSpreadTotalMoneyline
Nicholls St 3-7	N/A	N/A	N/A
SE Louisiana 8-3	N/A	N/A	N/A

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Friday 12:00 a.m.

November 21, 2025

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NCAAF Public Betting

SE Louisiana are 3-2 in their last 5 games.
SE Louisiana are 3-1 in their last 5 games against the spread
SE Louisiana are 3-3 in their road games against the spread
The totals have gone OVER in 3 of SE Louisiana' last 5 games
The totals have gone OVER in 3 of SE Louisiana' 4 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
SE Louisiana	6-4-1	3-1	3-3-1	5-3-1	0-1
Nicholls St	5-6	3-2	2-4	2-2	3-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
SE Louisiana	5-6	3-1	2-5	4-5	0-1
Nicholls St	3-8	1-4	2-4	1-3	2-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
SE Louisiana	8-3	N/A	N/A	8-1	0-1
Nicholls St	3-7	N/A	N/A	3-1	1-6

date	opponent	score	spread	over/under	moneyline
Nov 15th	@IW	W 10-7	-5.5 L	U 51.5	SEL -225
Nov 8th	@LAM	L 12-14	-7.5 L	U 49.5	LAM -278
Nov 1st	ETAM	W 59-14	-17.5 W	O 56.5	SEL -1200
Oct 25th	@HB	W 38-14	-23 W	U 52.5	SEL -3200
Oct 18th	NWS	W 49-0	-30.5 W	U 53.5	SEL -20000

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MatchupOverUnder
Nicholls St 3-7	N/A	N/A
SE Louisiana 8-3	N/A	N/A