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College Football Picks: Saturday’s Best Spread, Over/Under & Player Prop Bets

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Sep 13, 2025; Tempe, Arizona, USA; Arizona State Sun Devils head coach Kenny Dillingham. Credit: Arianna Grainey-Imagn Images

Action PRO's college football picks are red-hot heading into Saturday's Week 7 slate of games.

Wednesday's picks finished a perfect 3-0 (including a parlay win), followed by a clean 4-0 sweep on Thursday.

I'm covering seven best bets for Saturday using Action PRO's college football projections, betting systems and sharp-money insights, which fall on these games:

  • Alabama vs. Missouri (12 p.m. ET/ABC)
  • NIU vs. Eastern Michigan (1 p.m. ET/ESPN+)
  • Texas vs. Oklahoma (3:30 p.m. ET/ABC)
  • Indiana vs. Oregon (3:30 p.m. ET/CBS)
  • Purdue vs. Minnesota (7:30 p.m./Big Ten Network)
  • Arizona State vs. Utah (10:15 p.m. ET/ESPN)
  • Utah State vs. Hawaii (11:59 p.m. ET/Spectrum Sports)

Readers can expect college football picks for spreads, over/unders and recently-added player props.

Let's have a Saturday!


College Football Picks, Best Bets for Saturday

Alabama vs. Missouri Pick

Alabama is -3 in the best game of the early window.

After running our projections, a clear edge pops up in a high-profile SEC matchup. Tailing PRO's spread models reveals a savvy play backing the Missouri Tigers to stay within the number.

Our fair spread for Crimson Tide vs. Tigers in Week 7 is more like Alabama -1.4. Due to bettors grabbing a key number (+3), the projection lends a high grade of confidence. Also, Mizzou is shaping up to be the sharp side, with 98% of the money on 64% of the tickets we track.

Playbook

NIU vs. Eastern Michigan Pick

Northern Illinois vs. Eastern Michigan in a mid-afternoon MAC tilt is PRO's low-profile banger for Week 7.

NIU is -2.5, but our models shade a heavy edge to Eastern Michigan, at just Eagles +0.5.

This is also one of the most-lopsided pros vs. joes games: 62% of the tickets are backing Northern Illinois to cover, but all the money is on the underdog.


Texas vs. Oklahoma Pick

One of the best player props for Week 7 tailing PRO data is