The Ole Miss Rebels take on the Kentucky Wildcats in Lexington, Kentucky. Kickoff is set for 3:30 p.m. EDT on ABC.
Ole Miss is favored by 9.5 points on the spread with a moneyline of -350. The total is set at 50.5 points.
Here’s my Ole Miss vs Kentucky prediction and college football picks for Saturday, September 6, 2025.
Ole Miss Rebels vs Kentucky Wildcats Prediction, Picks
- Ole Miss vs Kentucky Pick: Kentucky +9.5 (Play to +8.5)
My Ole Miss vs Kentucky best bet is on the Wildcats to cover. Find the best line available on our live NCAAF odds page.
Ole Miss vs Kentucky Odds, Line, Spread
| Ole Miss Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-8.5 -115 | 51.5 -110o / -110u | -360 |
| Kentucky Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+8.5 -105 | 51.5 -110o / -110u | +280 |
- Ole Miss vs Kentucky Spread: Ole Miss -8.5, Kentucky +8.5
- Ole Miss vs Kentucky Over/Under: 51.5
- Ole Miss vs Kentucky Moneyline: Ole Miss ML -360, Kentucky ML +280
Ole Miss vs Kentucky Saturday NCAAF Preview
Ole Miss Rebels Betting Preview
Head coach Lane Kiffin has a pattern of annihilating Group of 5 competition early in the season, only to have a different performance on the road in the SEC.
Ole Miss dominated Georgia State, as half of the offensive possessions were explosive, averaging more than 10 yards per play.
New signal caller Austin Simmons filled the highlight reel, going 20-for-31 passing with multiple touchdowns in the opening game of the season.
Transfer wide receiver Harrison Wallace III from Penn State generated the most targets while hauling in five catches for 130 yards.
Running back Kewan Lacy recharged an Ole Miss backfield that lost numerous production pieces. The former Missouri running back generated six yards after first contact, posting three touchdowns on just 16 rushing attempts.
Kiffin has new names and faces on the field at the skill positions, but he's still running plenty of inside zone plays with considerable success.
Kentucky Wildcats Betting Preview
Quarterback Zach Calzada returned to Power 4 football after a stint at Incarnate Word.
The opening game for the Wildcats against Toledo was not promising for the former Texas A&M signal caller, failing to produce a touchdown pass or big-time throw.
On 10 of 23 passing, Calzada did not show improvement with decision-making, averaging a length of 3.1 seconds in time to throw metrics.
Kentucky was led once again by the defense in victory over the Rockets.
The rushing attack was stuffed by the Wildcats at a high 42% of attempts, posting only 3.1 yards per play on the ground. Toledo struggled in money downs, converting just eight of 21 attempts on third and fourth down.
After escaping Toledo with a 24-16 win, Kentucky enters the Ole Miss game with a mulligan for the offense.
Ole Miss vs Kentucky Week 2 NCAAF Pick to Bet
The Rebels have been a completely different team on the road in SEC play over the past two seasons, generally lighting up the scoreboard at home.
Across the past two seasons, Ole Miss has failed to score more than 27 points on the road against Florida, LSU, South Carolina, Mississippi State, Georgia and Alabama.
The box score was not the cleanest for Simmons in the opener against Georgia State. The sophomore posted three Turnover-Worthy Plays and an additional fumble against the Panthers.
Kentucky has continued defensive success in defending the zone read option, the preferred offensive scheme for Kiffin.
While this may be a revenge game from an Ole Miss loss that kept the Rebels out of the playoff last year, look for Kentucky to continue to flex on the Rebels' mistake-prone offense.
Pick: Kentucky +9.5 (Play to +8.5)
Ole Miss vs Kentucky Time, TV Channel, Location
- Time: 3:30 p.m. ET
- TV Channel: ABC
- Location: Kroger Field, Lexington, Kentucky
