Purdue vs. Michigan State Predictions, Picks, Odds, Friday NCAAF Betting Preview for Nov. 22

Purdue vs. Michigan State Predictions, Picks, Odds, Friday NCAAF Betting Preview for Nov. 22 article feature image
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Brandon Sloter/Image Of Sport/Getty Images. Pictured: Purdue RB Devin Mockobee.

The Michigan State Spartans (4-6, 2-5 Big Ten) will take on the Purdue Boilermakers (1-9, 0-7) in Spartan Stadium on Friday, Nov. 22, at 8 p.m. ET on FOX.

The Boilermakers have lost nine consecutive games; all hope is lost for this season. Beyond that, there are questions on what Purdue's football staff will look like next season. Head coach Ryan Walters may feel he is coaching for his job this week.

Michigan State has also fallen off a cliff, losing six of their last seven contests. The young Spartan offense hasn't developed as many fans hoped, but there is still plenty to play for as Michigan State attempts to become bowl-eligible.

Michigan State enters this Week 13 contest as a 13.5-point favorite on the spread, while the over/under sits at 47.5

So, where's the betting value here? Let's dive into my Michigan State vs. Purdue predictions and college football picks for Saturday.


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Purdue vs. Michigan State Predictions, Picks & Best Bets

  • Purdue vs Michigan State Pick: Purdue +13.5

My Purdue vs Michigan State best bet is on the Boilermakers to cover the spread, with the best line currently available at FanDuel, according to our live NCAAF odds page.


Purdue vs. Michigan State Odds, Betting Line

Purdue Boilermakers Logo
Friday, November 22
8 p.m. ET
FOX
Michigan State Spartans Logo
Purdue Boilermakers Odds
Point SpreadOver/UnderMoneyline
+14
-115
47.5
-120o / +100u
+425
Michigan State Spartans Odds
Point SpreadOver/UnderMoneyline
-14
-105
47.5
-120o / +100u
-650
Odds via ESPN Bet. Get up-to-the-minute NCAAF odds here.
ESPN Bet Logo
  • Purdue vs. Michigan State Spread: Michigan State -14
  • Purdue vs. Michigan State Total: 47.5 Total Points
  • Purdue vs. Michigan State Moneyline: Michigan State ML -650, Purdue ML +425


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Purdue Boilermakers vs. Michigan State Spartans NCAAF Betting Preview

Purdue Boilermakers

Purdue fans could not have imagined this season would go this poorly.

Against four top-20 opponents (Notre DameOregonOhio State and Penn State), Purdue has been outscored by a total of 195-17.

Now, a blowout loss counts the same as a one-point loss in the record books, but Purdue is a long way from playing competitive football against quality opponents.

The brutal schedule has made its winnable game opportunities more critical, though. We have seen Purdue play inspired football a handful of times in Big Ten, despite their season effectively being over for a month.

The Boilermakers took both Illinois and Northwestern to Overtime before falling short.

Purdue's only area of semi-successful play has been its rushing attack. Purdue ranks 64th in the nation at Rush Success Rate, and leaning on running back Devin Mockobee has been a successful formula.

Mockobee is averaging 5.7 yards per carry on the year, and he will need a hefty workload this week to keep Purdue in the game with a Michigan State team looking to clinch a bowl appearance.


Michigan State Spartans

Michigan State is an opponent that Purdue should be able to hang with if past precedent holds. The Spartans have been a disaster against teams of all shapes and sizes during Big Ten play, outside of a win over Iowa a few weeks ago.

Like Purdue, the only area in which Michigan State does well on offense is its rushing attack, which ranks 52nd in the country in Rush Success Rate.

The two-headed combo of KayRon Lynch-Adams and Nate Carter have a pick-your-poison feel, but both have been inconsistent week-to-week.

Defensively, it used to be the rushing defense that Michigan State held its hat on, but that has changed as of late.

The Spartans still rank 31st nationally in Rush Success Rate Allowed, but Illinois wore them down last week on the ground. Lead back Josh McCray ran nine times for 61 yards and three touchdowns, part of an all-around day of 138 yards rushing on 31 carries.

Mockobee has more upside as a rusher than McCray, and Purdue would be wise to lean on their star player repeatedly to control this game.

As all Michigan State games seem to do, this game may come down to Aidan Chiles' turnovers at the quarterback spot. Chiles has thrown 11 picks to just 10 touchdowns.

Chiles finally cleaned up his act last week, but it should be taken as a major red flag that Chiles avoided turnovers, and Michigan State still lost by 22 points to an Illinois team that Purdue took to Overtime.


Michigan State vs. Purdue Matchup Analysis

Toggle the dropdowns below to hide or show how Michigan State and Purdue match up statistically:

Purdue Offense vs. Michigan State Defense
Offense
Defense
Edge
Rush Success6431
Line Yards2325
Pass Success114115
Havoc116119
Finishing Drives11793
Quality Drives12285
Michigan State Offense vs. Purdue Defense
Offense
Defense
Edge
Rush Success5287
Line Yards116107
Pass Success94134
Havoc124124
Finishing Drives123125
Quality Drives62130
Pace of Play / Other
PFF Tackling10759
PFF Coverage131123
Special Teams SP+11730
Middle 8134126
Seconds per Play28.8 (107)29.8 (121)
Rush Rate55% (82)54% (88)

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How to Make My Purdue vs. Michigan State Bets

While it is hard to trust either of these teams, it is even harder to see Michigan State winning a game by two or more touchdowns.

The only opponent the Spartans have created separation against all year was Prairie View, and Purdue has perked up against the teams it has played this month that aren't monsters.

Michigan State may win, but Purdue will make things interesting.

Pick: Purdue +13.5


Purdue vs Michigan State Channel, How to Watch, Streaming, Location, Start Time

Location:Spartan Stadium, Lansing, MI
Date:Friday, Nov. 22
Kickoff Time:8 p.m. ET
TV / Streaming:FOX

Purdue vs Michigan State will be played at Spartan Stadium in Lansing, Michigan, on Friday, Nov. 22 at 8 p.m. ET. You can stream the game live on FOX.


Purdue vs. Michigan State Betting Trends


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About the Author
Greg Waddell writes college basketball previews for The Action Network and is a featured guest on the BBOC podcast. He has been betting on sports for 10 years and has worked in sports betting since 2022.

Follow Greg Waddell @gwizzy12 on Twitter/X.

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