The South Carolina State Bulldogs take on the USF Bulls in Tampa, FL. Kickoff is set for 12 p.m. ET on ESPN+.
USF is favored by -29.5 points on the spread with a moneyline of -8000. The total is set at 56.5 points.
Here’s my South Carolina State vs USF predictions and college football picks for Saturday, September 20, 2025.
