Panthers vs Bills Prediction, Picks, Odds for Saturday’s NFL Preseason Game

Panthers vs Bills Prediction, Picks, Odds for Saturday’s NFL Preseason Game article feature image
  • The Panthers' starters are set to see their first major action of the preseason, which is reason enough for our NFL betting expert to back Carolina on the spread Saturday.

The Carolina Panthers will visit the Buffalo Bills at Highmark Stadium on Saturday afternoon. Kickoff from Orchard Park is scheduled for 1 p.m. ET on NFL Network. The public might simply be going by name recognition, as the majority of tickets and money are currently backing the Bills to cover the spread against the Panthers.

We know better than to rely on name value when it comes to the preseason, though, which is why I’m happily joining the sharps and big money in backing Carolina covering as favorites. Let's preview the game and dive into my Panthers vs. Bills predictions for Saturday.

Panthers vs Bills Prediction

My Panthers-Bills pick is Carolina to cover the spread (-4.5), with the best line available at DraftKings, according to our live NFL odds page.

Panthers vs Bills Odds

Panthers Logo
Saturday, Aug 24
1:00pm ET
Bills Logo
Panthers Odds
SpreadTotalMoneyline
-4.5
-108
30.5
-110o / -110u
-198
Bills Odds
SpreadTotalMoneyline
+4.5
-112
30.5
-110o / -110u
+164
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Panthers vs Bills point spread: Panthers -4.5 | Bills +4.5
  • Panthers vs Bills total: Over/under 30.5
  • Panthers vs Bills moneylines: Panthers -198 | Bills +164

The spread opened at Panthers -4.5 and hasn't seen much movement since. The total has fallen a couple of points from 34.5 to 30.5.


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Panthers vs Bills Preview

The Panthers desperately need to see Bryce Young take a step forward. Actually, not just a step forward but a massive step forward. He completed only 59% of his passes for ,877 yards, 11 touchdowns and 10 interceptions for a 33.4 QBR that ranked 29th in the league. Not surprisingly, Carolina had the worst passing offense by far according to DVOA (-27.3%).

The Panthers cleaned house this offseason, hiring renowned QB whisperer Dave Canales as head coach. We don’t know how much progress has been made yet, as they still haven’t unleashed Young in preseason play.  They will this week, though, as the team’s starters are finally set to see their first action in the third and final game.

Why wait so long?

Canales told the media it’s because he wanted to wait until they had a full “grasp of the system.” Well, it sounds like they are ready now.

Meanwhile, there's not much that really needs to be said about a Buffalo Bills team that’s a far cry from what we’ll see come the regular season. They are hardly even a shell of their usual squad. Several key Bills reserves have suffered injuries, meaning the majority of those suiting up are third, fourth and fifth stringers

The team’s QB play might be the biggest warning sign in backing them. Mitch Trubisky is out for a few weeks with a knee injury, while Shane Buechele suffered a neck injury that landed him on IR. The latter forced Buffalo to sign Ben DeNucci last week, and then make a similar move on Wednesday, adding former Baltimore Raven Anthony Brown Jr. That means Buffalo will be led by a pair of passers who have been on the team for a combined 18 days.

How to Watch Panthers vs Bills Live: Start Time, Channel, Location

Location:Highmark Stadium, Orchard Park, NY
Date:Saturday, August 24, 2024
Time:1 p.m. ET
TV Channel/Live Streaming:NFL Network/NFL+

Panthers vs Bills will be broadcasted live on NFL Network, as well as local television coverage. Panthers-Bills is scheduled to kick off at 1 p.m. ET on Saturday afternoon at Highmark Stadium in Orchard Park.


Use Quickslip to Bet Panthers vs Bills


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My Panthers vs Bills Prediction: Carolina to Cover the Spread

Panthers vs Bills Best Bet

Canales' comments about holding his starters back until they fully grasped the system and were ready to execute seemed like pretty bold statements in my book. He believes we’re not seeing a team trying to work out the kinks. Instead, he’s saying we’ll see one who is ready to execute at a proper level.

Compare that to the Bills trotting out a bunch of players who will be filing for unemployment next week, and I’m rolling with the Panthers to cover the spread in this spot.

Panthers vs Bills Pick: Panthers -4.5 (-110)

Panthers vs Bills Betting Trends

  • 77% of bets and 52% of the money are on the Bills to cover the spread.
  • 60% of bets and 51% of the money are on the under.

All data via Action Network's public betting percentages.

Panthers vs Bills Weather

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About the Author
Ricky Henne writes for the Action Network's news team, covering all sports, events and breaking news. He also contributes to Action's NFL coverage. Ricky joined Action in 2022 with more than 20 years of experience covering professional sports. He wrote for the Los Angeles Chargers, New York Knicks and New York Rangers before entering the sports betting industry.

Follow Ricky Henne @rickyhenne on Twitter/X.

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