The New England Patriots (3-10) and Arizona Cardinals (6-7) will face off in NFL Week 15 at 4:25 p.m. ET from State Farm Stadium in Glendale. The game will be broadcast live on CBS.
Let's get into my Cardinals vs Patriots predictions and NFL picks.
The Cardinals are favored by 6.5 points with the game total set at 46.5 (-110/-110). The Cardinals are -278 moneyline favorites and the Patriots are +222 underdogs.
Patriots vs. Cardinals Predictions
Spread
While I don't have a pick on the full-game spread, I like the Cardinals to cover the first-half spread against the Patriots.
Moneyline
I don't see any value on the moneyline in this one.
Over/Under
I don't have a pick on the total in this game either.
My Pick: Cardinals 1H -3.5
Patriots vs. Cardinals Odds, Spread, Over/Under
| Patriots Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 46.5 -110o / -110u | +222 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 46.5 -110o / -110u | -278 |
- Patriots vs. Cardinals spread: Patriots +6.5 (-110), Cardinals -6.5 (-110)
- Patriots vs. Cardinals over/under: 46.5 (-110/-110)
- Patriots vs. Cardinals moneyline: Patriots +222, Cardinals -278
- Patriots vs. Cardinals best bet: Cardinals 1H -3.5
MyPatriots vs. Cardinals best bet is on Cardinals 1H -3.5. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Patriots vs. Cardinals Preview, Prediction — Week 15
This would usually be a spot that I’d be looking to fade the Patriots. They’re coming off a tough loss (but they covered!) and have to travel across the country to face a team playing for its playoff life.
Also, the Patriots defense is the worst in the NFL in Weighted DVOA, which takes into account recent performances more than the entirety of the season. It’s not like defensive DVOA is kinder to New England, which is 31st in that category.
The Cardinals are 14th in Weighted DVOA on defense and 10th on offense. They have lost three straight, but the performances haven’t been that bad.
Arizona ran into a surging Seahawks team — that just got its defense healthy recently — twice in the last three games, with a trip to face the Vikings sandwiched between those losses.
While obviously being two games behind the Seahawks and losing the tiebreaker has all but doomed the Cardinals’ playoff hopes, I don’t anticipate Arizona will just lay down and accept that its season is over.
So, how do we do that?
I’m hesitant to recommend a bet on the Cardinals against the spread (ATS) since Kyler Murray notoriously struggles later in the season. He’s 26-14 ATS in September or October in his career, but 16-21-2 after Nov. 1.
This season, Drake Maye is 2-6 against the first-half spread, which is the third-worst mark in the NFL ahead of only Trevor Lawrence and Caleb Williams. Like Williams, Maye has done well in the second half at 5-1 against the second-half spread in his last six starts.
I’d play the Cardinals against the first-half spread at -4 or lower, but there are still some 3.5s on the board — use our live NFL odds page to find those. If you wanted to parlay that with Patriots 2H +4, I wouldn’t blame you.
My Pick: Cardinals 1H -3.5
Patriots vs Cardinals Betting Trends
Patriots vs Cardinals Latest Injuries
Patriots Injuries
| Player | Status |
|---|---|
| WR Javon Baker | Out (concussion) |
| DT Jaquelin Roy | Out (foot) |
| T Caedan Wallace | Out (ankle) |
| S Kyle Dugger | Questionable (ankle) |
| CB Christian Gonzalez | Questionable (shoulder) |
| T Vederian Lowe | Questionable (shoulder) |
| G Cole Strange | Questionable (knee) |
| DT Christian Barmore | Questionable (not injury related) |
Cardinals Injuries
| Player | Status |
|---|---|
| RB Emari Demercado | Out (back) |
| P Blake Gillikin | Out (foot) |
| CB Elijah Jones | Questionable (ankle) |
| DT Naquan Jones | Questionable (shoulder) |
| DT Roy Lopez | Questionable (ankle) |
