| Ruben Loftus-Cheek | MID | Out | Heel Injury | Heel Injury | Jan 5 |
| Fikayo Tomori | DEF | Out | Knock | Knock | Jul 11 |
| Strahinja Pavlovic | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Yerry Mina | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Leonardo Pavoletti | F | Doubtful | Leonardo Pavoletti is Doubtful with Physical discomfort. | Pavoletti is doubtful with soreness | Apr 8 |
| Mattia Felici | F | Out for season | Mattia Felici is Out for season with Cruciate ligament injury. | Felici is out for season with knee | Mar 16 |
| Riyad Idrissi | DEF | Out for season | Riyad Idrissi is Out for season with Cruciate ligament injury. | Idrissi is out for season with knee | Mar 11 |
| Alberto Moreno | DEF | Out | Suspended | Suspended | Feb 18 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Alvaro Morata | F | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Youssef Maleh | MID | Suspended | Youssef Maleh is serving a suspension for Red card. | Maleh is suspended with red card | Apr 5 |
| Michele Collocolo | MID | Doubtful | Michele Collocolo is Doubtful with Hamstring Injury. | Collocolo is doubtful with hamstring | Mar 9 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Abdelhamid Sabiri | MID | Out | Suspended | Suspended | Jun 16 |
| Manor Solomon | MID | Out | Knee Injury | Knee Injury | Jan 5 |
| Tariq Lamptey | DEF | Out indefinitely | Tariq Lamptey is Unknown with Knee injury. | Lamptey is injured with knee | Aug 26 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Fabiano Parisi | DEF | Doubtful | Fabiano Parisi is Doubtful with Knock injury. | Parisi is doubtful with knock injury | Apr 3 |
| Albert Gudmundsson | F | Suspended | Albert Gudmundsson is serving a suspension for Red card. | Gudmundsson is suspended with red card | Apr 5 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Brooke Norton-Cuffy | DEF | Out | Brooke Norton-Cuffy is expected to return Late April 2026 from Hamstring Injury. | Norton-Cuffy is out with hamstring | Apr 8 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| Sandi Lovric | MID | Doubtful | Sandi Lovric is Doubtful with Muscle injury. | Lovric is doubtful with muscle | Feb 12 |
| Tomas Suslov | MID | Suspended | Tomas Suslov is serving a suspension for Red card. | Suslov is suspended with red card | Apr 5 |
| Moatasem Al-Musrati | MID | Out indefinitely | None | Al-Musrati is injured | May 9 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Yann Sommer | GK | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Dec 6 |
| Yann Bisseck | DEF | Out | Yann Aurel Bisseck is expected to return Late April 2026 from Thigh injury. | Bisseck is out with thigh | Apr 8 |
| Filip Kostic | F | Out indefinitely | Virus | Virus | Jan 24 |
| Mattia Perin | GK | Out | Matia Perin is expected to return Late April 2026 from Calf injury. | Perin is out with calf | Apr 8 |
| Arkadiusz Milik | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 22 |
| Pedro | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Sep 28 |
| Ivan Provedel | GK | Out for season | Ivan Provedel is Out for season with Shoulder injury. | Provedel is out for season with shoulder | Mar 8 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Toma Basic | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 14 |
| Nicolo Rovella | MID | Out | Nicolò Rovella is expected to return Early May 2026 from Broken collarbone. | Rovella is out with collarbone | Feb 23 |
| Mattia Zaccagni | F | Doubtful | Mattia Zaccagni is Doubtful with Muscle injury. | Zaccagni is doubtful with muscle | Apr 8 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Riccardo Sottil | F | Out | Riccardo Sottil is expected to return Late April 2026 from Muscle injury. | Sottil is out with muscle | Apr 8 |
| Antonino Gallo | DEF | Doubtful | Antonino Gallo is Doubtful with Physical discomfort. | Gallo is doubtful with soreness | Apr 4 |
| Medon Berisha | F | Out | Medon Berisha is expected to return Late April 2026 from Hamstring Injury. | Berisha is out with hamstring | Apr 8 |
| Kialonda Gaspar | DEF | Out | Kialonda Gaspar is expected to return Late April 2026 from Knee injury. | Gaspar is out with knee | Apr 8 |
| Mateo Pellegrino | F | Suspended | Mateo Pellegrino is serving a suspension for Yellow cards. | Pellegrino is suspended with yellow cards | Apr 5 |
| Matija Frigan | F | Out | Matija Frigan is expected to return Mid May 2026 from Cruciate ligament injury. | Frigan is out with knee | Apr 8 |
| Daniel Tyrell Denoon | DEF | Doubtful | Daniel Denoon is Doubtful with Muscle injury. | Denoon is doubtful with muscle | Mar 16 |
| Marius Marin | MID | Out | Marius Marin is expected to return Late April 2026 from Muscle injury. | Marin is out with muscle | Apr 8 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Giovanni Di Lorenzo | DEF | Doubtful | Giovanni Di Lorenzo is Doubtful with Knee injury. | Di Lorenzo is doubtful with knee | Mar 29 |
| Amir Rrahmani | DEF | Doubtful | Amir Rrahmani is Doubtful with Thigh injury. | Rrahmani is doubtful with thigh | Mar 25 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Antonio Vergara | MID | Out | Antonio Vergara is expected to return Late April 2026 from Foot injury. | Vergara is out with foot | Apr 8 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Filippo Romagna | DEF | Out | Filippo Romagna is expected to return Late April 2026 from Knee injury. | Romagna is out with knee | Apr 10 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Edoardo Pieragnolo | DEF | Doubtful | Edoardo Pieragnolo is Doubtful with Muscle injury. | Pieragnolo is doubtful with muscle | Dec 28 |
| Daniel Boloca | MID | Out | Daniel Boloca is expected to return Early May 2026 from Meniscus injury. | Boloca is out with knee | Apr 8 |
| Jeroen Zoet | GK | Out indefinitely | Knock | Knock | Oct 20 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Duvan Zapata | F | Out | Duván Zapata is expected to return Late April 2026 from Thigh injury. | Zapata is out with thigh | Apr 8 |
| Adrien Tameze | MID | Out | Back Injury | Back Injury | Oct 6 |
| Guillermo Maripan | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 13 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Zannetos Savva | MID | Doubtful | Savva, Zannetos: doubtful - injured | Savva is doubtful | Aug 22 |
| Sandro Kulenovic | F | Suspended | Sandro Kulenovic is serving a suspension for Yellow cards. | Kulenovic is suspended with yellow cards | Dec 21 |
| Kingsley Ehizibue | DEF | Out indefinitely | Concussion | Concussion | Apr 17 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
