| Ruben Loftus-Cheek | MID | Out | Heel Injury | Heel Injury | Jan 5 |
| Christian Pulisic | F | Out | Knock | Knock | Mar 4 |
| Mike Maignan | GK | Out | Suspended | Suspended | Aug 20 |
| Luka Modric | MID | Doubtful | None | Modric is doubtful | Dec 1 |
| Alvaro Morata | F | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Fikayo Tomori | DEF | Out | Knock | Knock | Jul 11 |
| Pervis Estupinan | DEF | Out | Hamstring | Hamstring | Apr 21 |
| Rafael Leao | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 4 |
| Strahinja Pavlovic | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Ademola Lookman | F | Out indefinitely | Illness | Illness | Dec 27 |
| Sead Kolasinac | DEF | Out | Groin Strain | Groin Strain | Mar 31 |
| Gianluca Scamacca | F | Out | Gianluca Scamacca is expected to return Early October 2025 from Knee injury. | Scamacca is out with knee | Sep 18 |
| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Kamaldeen Sulemana | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Isak Hien | DEF | Out | Isak Hien is expected to return Early October 2025 from Muscle injury. | Hien is out with muscle | Sep 21 |
| Odilon Kossounou | DEF | Out indefinitely | None | Kossounou is injured | Feb 13 |
| Giorgio Scalvini | DEF | Out | Giorgio Scalvini is expected to return Early October 2025 from Muscle injury. | Scalvini is out with muscle | Sep 18 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Andrea Belotti | F | Out | Andrea Belotti is expected to return Early April 2026 from Cruciate ligament injury. | Belotti is out with knee | Sep 29 |
| Yerry Mina | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Zito Luvumbo | F | Out | Zito Luvumbo is expected to return Mid October 2025 from Muscle injury. | Luvumbo is out with muscle | Sep 29 |
| Boris Radunovic | GK | Out indefinitely | Boris Radunovic is Unknown with Calf injury. | Radunovic is injured with calf | Sep 18 |
| Marko Rog | MID | Out indefinitely | None | Rog is injured | Feb 14 |
| Gabriele Zappa | DEF | Doubtful | Gabriele Zappa is Doubtful with Muscle injury. | Zappa is doubtful with muscle | Sep 25 |
| Alberto Moreno | DEF | Out | Suspended | Suspended | Feb 18 |
| Alberto Cerri | F | Out indefinitely | None | Cerri is injured | May 22 |
| Ignace Van Der Brempt | DEF | Doubtful | Ignace Van der Brempt is Doubtful with Muscle injury. | Van Der Brempt is doubtful with muscle | Sep 29 |
| Antonio Sanabria | F | Out | Suspended | Suspended | Feb 4 |
| Jeremy Sarmiento | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Pablo Mari | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 13 |
| Marin Pongracic | DEF | Out | Suspended | Suspended | Mar 6 |
| Abdelhamid Sabiri | MID | Out | Suspended | Suspended | Jun 16 |
| Tariq Lamptey | DEF | Out indefinitely | Tariq Lamptey is Unknown with Knee injury. | Lamptey is injured with knee | Aug 26 |
| Mattia Viti | DEF | Out indefinitely | None | Viti is injured | Feb 13 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Junior Messias | F | Out | Junior Messias is expected to return Mid October 2025 from Muscle injury. | Messias is out with muscle | Sep 26 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Abdou Harroui | MID | Out | Abdou Harroui is expected to return Mid October 2025 from Muscle injury. | Harroui is out with muscle | Sep 29 |
| Tomas Suslov | MID | Out | Tomas Suslov is expected to return Late February 2026 from Cruciate ligament injury. | Suslov is out with knee | Aug 26 |
| Daniel Mosquera | F | Out | Daniel Mosquera is expected to return Mid October 2025 from Appendicitis. | Mosquera is out with appendix | Sep 29 |
| Nicolas Valentini | DEF | Doubtful | Nicolás Valentini is Doubtful with Hamstring Injury. | Valentini is doubtful with hamstring | Sep 18 |
| Daniel Oyegoke | DEF | Doubtful | Daniel Oyegoke is Doubtful with Muscle injury. | Oyegoke is doubtful with muscle | Sep 29 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Yann Sommer | GK | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Dec 6 |
| Filip Kostic | F | Out indefinitely | Virus | Virus | Jan 24 |
| Daniele Rugani | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Jan 19 |
| Arkadiusz Milik | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 22 |
| Nico Gonzalez | F | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Jun 14 |
| Tim Weah | F | Out | Foot Injury | Foot Injury | Oct 2 |
| Teun Koopmeiners | MID | Out indefinitely | None | Koopmeiners is injured | Nov 2 |
| Fabio Miretti | MID | Out indefinitely | Miretti, Fabio: missing - injured | Miretti is injured | Aug 22 |
| Pedro | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Sep 28 |
| Matteo Guendouzi | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 2 |
| Matias Vecino | MID | Doubtful | Matias Vecino is Doubtful with Muscle injury. | Vecino is doubtful with muscle | Sep 9 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Toma Basic | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 14 |
| Taty Castellanos | F | Out | Suspended | Suspended | Jan 14 |
| Manuel Lazzari | MID | Out | Manuel Lazzari is expected to return Mid October 2025 from Muscle injury. | Lazzari is out with muscle | Sep 29 |
| Nicolo Rovella | MID | Doubtful | Nicolò Rovella is Doubtful with Muscle injury. | Rovella is doubtful with muscle | Sep 26 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Frederic Guilbert | DEF | Out | Chest Injury | Chest Injury | Dec 12 |
| Tete Morente | F | Out indefinitely | Toe Injury | Toe Injury | Feb 16 |
| Gaby Jean | DEF | Out indefinitely | Jean, Gaby: missing - injured | Jean is injured | Aug 22 |
| Hernani | MID | Doubtful | Hernani is Doubtful with Thigh injury. | Hernani is doubtful with thigh | Sep 18 |
| Lautaro Valenti | DEF | Doubtful | Lautaro Valenti is Doubtful with Muscle injury. | Valenti is doubtful with muscle | Sep 28 |
| Jacob Ondrejka | MID | Out | Jacob Ondrejka is expected to return Mid December 2025 from Fibula. | Ondrejka is out with fibula | Sep 29 |
| Raul Albiol | DEF | Out indefinitely | Hamstring | Hamstring | Jan 30 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Romelu Lukaku | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Sep 16 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Mathias Olivera | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Giovanni Di Lorenzo | DEF | Suspended | Giovanni Di Lorenzo is serving a suspension for Red card. | Di Lorenzo is suspended with red card | Sep 25 |
| Alessandro Buongiorno | DEF | Out | Alessandro Buongiorno is expected to return Late October 2025 from Muscle injury. | Buongiorno is out with muscle | Sep 24 |
| Amir Rrahmani | DEF | Out | Amir Rrahmani is expected to return Late October 2025 from Hamstring Injury. | Rrahmani is out with hamstring | Sep 29 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Nikita Contini | GK | Out | Nikita Contini is expected to return Late October 2025 from Broken hand. | Contini is out with hand | Sep 12 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Yeferson Paz Blandon | DEF | Out | Yeferson Paz is expected to return Mid October 2025 from Muscle injury. | Paz Blandon is out with muscle | Sep 29 |
| Jeroen Zoet | GK | Out indefinitely | Knock | Knock | Oct 20 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Adrien Tameze | MID | Out | Back Injury | Back Injury | Oct 6 |
| Guillermo Maripan | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 13 |
| Perr Schuurs | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 19 |
| Zannetos Savva | MID | Doubtful | Savva, Zannetos: doubtful - injured | Savva is doubtful | Aug 22 |
| Kingsley Ehizibue | DEF | Out indefinitely | Concussion | Concussion | Apr 17 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
| Maduka Okoye | GK | Suspended | Maduka Okoye is serving a suspension for Gambling. | Okoye is suspended with gambling | Sep 11 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
