| Ruben Loftus-Cheek | MID | Out | Heel Injury | Heel Injury | Jan 5 |
| Christian Pulisic | F | Out | Knock | Knock | Mar 4 |
| Mike Maignan | GK | Out | Suspended | Suspended | Aug 20 |
| Luka Modric | MID | Doubtful | None | Modric is doubtful | Dec 1 |
| Fikayo Tomori | DEF | Out | Knock | Knock | Jul 11 |
| Pervis Estupinan | DEF | Out | Hamstring | Hamstring | Apr 21 |
| Rafael Leao | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 4 |
| Matteo Gabbia | DEF | Out | Matteo Gabbia is expected to return Early April 2026 from Hernia. | Gabbia is out with hernia | Mar 4 |
| Strahinja Pavlovic | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Davide Bartesaghi | DEF | Doubtful | Davide Bartesaghi is Doubtful with Physical discomfort. | Bartesaghi is doubtful with soreness | Mar 2 |
| Sead Kolasinac | DEF | Out | Groin Strain | Groin Strain | Mar 31 |
| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Kamaldeen Sulemana | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Ederson | MID | Doubtful | Ederson José is Doubtful with Physical discomfort. | Ederson is doubtful with soreness | Mar 3 |
| Charles De Ketelaere | F | Out | Charles De Ketelaere is expected to return Late March 2026 from Knee injury. | De Ketelaere is out with knee | Feb 11 |
| Giacomo Raspadori | F | Out | Giacomo Raspadori is expected to return Mid March 2026 from Muscle injury. | Raspadori is out with muscle | Feb 27 |
| Odilon Kossounou | DEF | Out indefinitely | None | Kossounou is injured | Feb 13 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Andrea Belotti | F | Out | Andrea Belotti is expected to return Early April 2026 from Cruciate ligament injury. | Belotti is out with knee | Dec 5 |
| Yerry Mina | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Gianluca Gaetano | MID | Out | Gianluca Gaetano is expected to return Mid March 2026 from Muscle injury. | Gaetano is out with muscle | Feb 27 |
| Luca Mazzitelli | MID | Out | Luca Mazzitelli is expected to return Mid March 2026 from Muscle injury. | Mazzitelli is out with muscle | Mar 3 |
| Alessandro Deiola | MID | Out | Alessandro Deiola is expected to return Mid March 2026 from Thigh injury. | Deiola is out with thigh | Feb 27 |
| Gennaro Borrelli | F | Out | Gennaro Borrelli is expected to return Mid March 2026 from Muscle injury. | Borrelli is out with muscle | Feb 27 |
| Alberto Moreno | DEF | Out | Suspended | Suspended | Feb 18 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Alvaro Morata | F | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Antonio Sanabria | F | Out | Suspended | Suspended | Feb 4 |
| Federico Baschirotto | DEF | Out | Federico Baschirotto is expected to return Mid March 2026 from Muscle injury. | Baschirotto is out with muscle | Feb 23 |
| Filippo Terracciano | MID | Suspended | Filippo Terracciano is serving a suspension for Yellow cards. | Terracciano is suspended with yellow cards | Mar 1 |
| Michele Collocolo | MID | Out | Michele Collocolo is expected to return Mid March 2026 from Hamstring Injury. | Collocolo is out with hamstring | Feb 27 |
| Martin Payero | MID | Doubtful | Martín Payero is Doubtful with Physical discomfort. | Payero is doubtful with soreness | Mar 3 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Marin Pongracic | DEF | Out | Suspended | Suspended | Mar 6 |
| Abdelhamid Sabiri | MID | Out | Suspended | Suspended | Jun 16 |
| Manor Solomon | MID | Out | Knee Injury | Knee Injury | Jan 5 |
| Tariq Lamptey | DEF | Out indefinitely | Tariq Lamptey is Unknown with Knee injury. | Lamptey is injured with knee | Aug 26 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Fabiano Parisi | DEF | Suspended | Fabiano Parisi is serving a suspension for Yellow cards. | Parisi is suspended with yellow cards | Mar 3 |
| Luca Lezzerini | GK | Out | Luca Lezzerini is expected to return Mid March 2026 from Thigh injury. | Lezzerini is out with thigh | Feb 27 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Brooke Norton-Cuffy | DEF | Doubtful | Brooke Norton-Cuffy is Doubtful with Thigh injury. | Norton-Cuffy is doubtful with thigh | Feb 24 |
| Sebastian Otoa | DEF | Doubtful | Sebastian Otoa is Doubtful with Thigh injury. | Otoa is doubtful with thigh | Feb 21 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Pol Lirola | DEF | Doubtful | Pol Lirola is Doubtful with Muscle injury. | Lirola is doubtful with muscle | Feb 27 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| Sandi Lovric | MID | Doubtful | Sandi Lovric is Doubtful with Muscle injury. | Lovric is doubtful with muscle | Feb 12 |
| Moatasem Al-Musrati | MID | Out indefinitely | None | Al-Musrati is injured | May 9 |
| Rafik Belghali | DEF | Out | Rafik Belghali is expected to return Mid March 2026 from Muscle injury. | Belghali is out with muscle | Feb 27 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Yann Sommer | GK | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Dec 6 |
| Lautaro Martinez | F | Out | Lautaro Martinez is expected to return Late March 2026 from Calf injury. | Martinez is out with calf | Feb 20 |
| Filip Kostic | F | Out indefinitely | Virus | Virus | Jan 24 |
| Arkadiusz Milik | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 22 |
| Emil Holm | DEF | Out | Emil Holm is expected to return Mid March 2026 from Calf injury. | Holm is out with calf | Feb 27 |
| Teun Koopmeiners | MID | Out indefinitely | None | Koopmeiners is injured | Nov 2 |
| Pedro | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Sep 28 |
| Elseid Hysaj | DEF | Doubtful | Elseid Hysaj is Doubtful with Physical discomfort. | Hysaj is doubtful with soreness | Feb 28 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Toma Basic | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 14 |
| Nicolo Rovella | MID | Out | Nicolò Rovella is expected to return Early May 2026 from Broken collarbone. | Rovella is out with collarbone | Feb 23 |
| Daniel Maldini | F | Out | Daniel Maldini is expected to return Mid March 2026 from Thigh injury. | Maldini is out with thigh | Feb 28 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Medon Berisha | F | Doubtful | Medon Berisha is Doubtful with Knee injury. | Berisha is doubtful with knee | Feb 19 |
| Kialonda Gaspar | DEF | Out indefinitely | Kialonda Gaspar is Unknown with Knee injury. | Gaspar is injured with knee | Feb 22 |
| Pontus Almqvist | F | Out | Pontus Almqvist is expected to return Mid March 2026 from Muscle injury. | Almqvist is out with muscle | Feb 27 |
| Matija Frigan | F | Out | Matija Frigan is expected to return Early May 2026 from Cruciate ligament injury. | Frigan is out with knee | Feb 27 |
| Simone Scuffet | GK | Out | Simone Scuffet is expected to return Mid March 2026 from Muscle injury. | Scuffet is out with muscle | Feb 27 |
| Isak Vural | MID | Out | Isak Vural is expected to return Mid March 2026 from Knee injury. | Vural is out with knee | Feb 27 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Romelu Lukaku | F | Out | Romelu Lukaku is expected to return Early November 2025 from Thigh injury. | Lukaku is out with thigh | Oct 20 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Mathias Olivera | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Giovanni Di Lorenzo | DEF | Out | Giovanni Di Lorenzo is expected to return Late March 2026 from Knee injury. | Di Lorenzo is out with knee | Feb 27 |
| Amir Rrahmani | DEF | Out | Amir Rrahmani is expected to return Mid March 2026 from Thigh injury. | Rrahmani is out with thigh | Feb 27 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Andrea Pinamonti | F | Suspended | Andrea Pinamonti is serving a suspension for Red card. | Pinamonti is suspended with red card | Mar 1 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Edoardo Pieragnolo | DEF | Doubtful | Edoardo Pieragnolo is Doubtful with Muscle injury. | Pieragnolo is doubtful with muscle | Dec 28 |
| Daniel Boloca | MID | Out | Daniel Boloca is expected to return Mid May 2026 from Meniscus injury. | Boloca is out with knee | Feb 27 |
| Jeroen Zoet | GK | Out indefinitely | Knock | Knock | Oct 20 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Adrien Tameze | MID | Out | Back Injury | Back Injury | Oct 6 |
| Guillermo Maripan | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 13 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Zannetos Savva | MID | Doubtful | Savva, Zannetos: doubtful - injured | Savva is doubtful | Aug 22 |
| Sandro Kulenovic | F | Suspended | Sandro Kulenovic is serving a suspension for Yellow cards. | Kulenovic is suspended with yellow cards | Dec 21 |
| Kingsley Ehizibue | DEF | Out indefinitely | Concussion | Concussion | Apr 17 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
| Oumar Solet | DEF | Out | Oumar Solet is expected to return Mid March 2026 from Muscle injury. | Solet is out with muscle | Feb 25 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
