49ers vs. Colts Odds & Betting Predictions - December 23, 2025
49ers at Colts
1:15 am • ESPN49ers at Colts Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
49ers 11-4 | -3 | -4.5-106 | o46.5-102 | -221 |
Colts 8-7 | u46.5 | +4.5-113 | u46.5-114 | +185 |

Lucas Oil StadiumIndianapolis
49ers vs. Colts Expert Picks
Sandy Plashkes
Last 30d: 104-135-1 (-45.7u)
M.Pittman o23.5 Rec Yds (Live)-120
2u
Cam Is Money
Last 30d: 118-102-4 (+3.9u)
IND +9.5 (Live)-115
1u
Kyle Murray
Last 30d: 104-95-3 (+34.3u)
Under 46.5-110
1.1u
Boomer Betz
Last 30d: 112-119-1 (-9.5u)
K.Bourne o49.5 Rec Yds+259
0.25u
K.Bourne Anytime TD Scorer Yes+450
0.2u
K.Bourne o24.5 Rec Yds-128
1u
K.Bourne o39.5 Rec Yds+166
0.5u

Chris Raybon
Last 30d: 19-20-2 (+2.8u)
IND +4.5-112
1u
Markus Markets
Last 30d: 39-30-0 (+3.7u)
A.Abdullah o1.5 Recs+120
1u
Vegas Refund
Last 30d: 33-37-1 (-8.0u)
SF -4-110
1u
💰🦡 Jake
Last 30d: 86-94-1 (-7.4u)
J.Downs First Touchdown Scorer Yes+2250
0.1u
The Degenerates
Last 30d: 102-93-4 (+0.8u)
SF -5.5-105
1u
Allan Lem
Last 30d: 173-135-2 (+5.4u)
D.Winters u7.5 Tackles + Ast+108
0.5u
Tailing @The_Oddsmaker
RocketPlays
Last 30d: 35-118-2 (+9.6u)
A.Abdullah o1.5 Recs+120
1u
A.Abdullah o2.5 Recs+350
0.5u
A.Abdullah o3.5 Recs+900
0.25u
Sean Koerner
Last 30d: 37-34-0 (+0.1u)
D.Winters u7.5 Tackles + Ast+108
0.54u
When looking into Winters’ tackle prop, it’s ideal to focus on his role from Week 7 on, as Fred Warner went down with a season-ending injury in Week 6. That was such a massive blow to the defense and clearly impacts Winters’ tackle rate. Tatum Bethune is also expected to be back in the lineup for the first time since Week 11, which should shake things up a bit as well.
In terms of Winters’ tackle profile, he’s recorded a tackle on roughly 12% of opponents’ rush attempts and around 9% of opponent dropbacks. I am expecting the Colts to be fairly run heavy, with the 49ers facing around +3 more rush attempts than usual. Winters also tends to mix in on scrambles at a higher rate, which Rivers won’t provide, and I have him projected to be involved on around ~3 Jonathan Taylor runs.
However, I have the 49ers expected to face roughly ~5.5 fewer pass completions in this game, which eats into Winters’ upside quite a bit. While a lower aDOT could allow him to mix in slightly more underneath, I also expect safety Malik Mustapha to play in the box at a higher rate and pick up some of those tackle opportunities. This is also a game where the 49ers could dominate time of possession and keep their defense off the field more than usual.
All of this leads me to project Winters closer to 6.9 tackles, with around a 62% chance to stay under 7.5. It’s that time of year where the tackle prop market is pretty sharp. Earlier today, his under 7.5 was closer to -140, which I was much more in line with, but with it getting bet up to +108, I think there’s enough value to lock it in.
Allan Lem
Last 30d: 173-135-2 (+5.4u)
A.Pierce u21.5 Rec Yds-110
0.55u
Tailing @The_Oddsmaker
Sean Koerner
Last 30d: 37-34-0 (+0.1u)
A.Pierce u21.5 Rec Yds-110
0.55u
Pierce’s under was the prop I was considering for this game ever since I mentioned on the TD show that he likely takes the biggest hit with Rivers under center for the Colts. But this morning I noticed that Pierce’s over rec yds is one of the top 5 most-bet props, with 99% of the action on his over.
I’m not too surprised. Last week was the first time he was held below 25 rec yds all season, going just 1/16/0. He has cleared this number in 11 of 12 games, but I still think this is a spot to “sell high” on Pierce and buck the 92% trend of him clearing this number this year.
Rivers’ average depth of target last week was just 4.7 yards downfield, which would be by far the lowest on the season among qualified passers. He attempted only two passes 20+ yards downfield, one incomplete to Jonathan Taylor and one to Michael Pittman that was intercepted. His only pass to Pierce was a contested catch 15 yards downfield that Next Gen Stats gave roughly a 45% chance of being completed, meaning Pierce was essentially a 55% chance to finish with zero catches last week.
While I expect Rivers to be a bit sharper this week and attempt a few more passes, it’s still likely a downgrade for Pierce specifically. He’s averaging a league-high 18.9 aDOT and tends to see a high percentage of tight-window, contested throws. In order to clear this, he likely needs one or two downfield attempts from Rivers and to connect on one with a sub-50% completion probability, which is certainly possible. The other path would be the Colts scheming him more quick-hitting routes, but that seems unlikely with Tyler Warren and Josh Downs better suited for those looks, along with Jonathan Taylor and Ameer Abdullah both seeing increased target rates, all at Pierce’s expense.
He remains a boom/bust option who could finish with another 1/16/0 line or just as easily post a 2/80/1 line. I’m simply showing the odds of his floor outcomes being a bit higher here, with a median closer to 16.5 rec yds and around a 60% chance to stay under 21.5.
Picks Office
Last 30d: 188-134-1 (+35.1u)
IND +5.5-110
1u
Join Discord: https://discord.gg/NcyhmJVXPe
YBK Picks.com
Last 30d: 36-29-1 (+8.3u)
IND +4.5-105
2u
John Feltman
Last 30d: 67-57-1 (-4.8u)
IND +4.5-110
1.1u
💰🦡 Jake
Last 30d: 86-94-1 (-7.4u)
Under 23.5 (1H)-120
1.8u
J.Downs o3.5 Recs+120
1.2u
B.Purdy o244.5 Pass Yds-110
1u
Austin Pendergrass
Last 30d: 32-40-0 (-13.2u)
G.Kittle 60+ Receiving Yards Yes-160
0.31u
Nick Giffen
Last 30d: 41-87-1 (-3.1u)
M.Pittman o30.5 Rec Yds-110
0.5u
Action Island
Roger Goodell
Last 30d: 38-53-1 (-12.3u)
Under 23.5 (1H)-110
1u
Cam Is Money
Last 30d: 118-102-4 (+3.9u)
M.Pittman Anytime TD Scorer Yes+330
0.4u
M.Pittman o39.5 Rec Yds+140
0.4u
M.Pittman o31.5 Rec Yds-120
0.83u
Boomer Betz
Last 30d: 112-119-1 (-9.5u)
Under 46.5-104
1.04u
Px
G.Kittle u69.5 Rec Yds-122
1.22u
Kalshi
Player Prop Savant
Last 30d: 51-43-0 (+4.9u)
D.Winters o7.5 Tackles + Ast+109
1u
Bet Labs
Last 30d: 24-12-0 (+10.3u)
IND +5.5-105
1.05u
Kyle Murray
Last 30d: 104-95-3 (+34.3u)
C.McCaffrey u62.5 Rush Yds+100
1u
J.Taylor o18.5 Rec Yds-110
1u
Grant Neiffer
Last 30d: 44-102-1 (-4.1u)
P.Rivers 225+ Passing Yards Yes+650
0.65u
P.Rivers 250+ Passing Yards Yes+1300
1.3u
P.Rivers o158.5 Pass Yds-110
1u
P.Rivers 200+ Passing Yards Yes+320
0.32u
J.Jennings Anytime TD Scorer Yes+160
0.4u
DeadPresPicks
Last 30d: 5-6-0 (+0.6u)
M.Pittman o31.5 Rec Yds-110
0.91u
Ryan Sura
Last 30d: 4-4-0 (-0.2u)
J.Jennings o54.5 Rec Yds-120
1u
Sandy Plashkes
Last 30d: 104-135-1 (-45.7u)
IND +6-115
1.15u
Invisible Insider
Last 30d: 15-16-0 (-2.7u)
J.Jennings o54.5 Rec Yds-114
0.88u
Under 23.5 (1H)-120
1u
Over 46-110
0.91u
J.Taylor 100+ Rushing Yards Yes-106
1u
Action Pod NFL Picks
Last 30d: 71-154-6 (-19.1u)
IND +220
0.45u
@wheatonbrando https://myaction.app/1o1Q7l38iZb
E.Pineiro o7.5 Kicking Pts-110
0.91u
@EvanHAbrams https://myaction.app/1o1Q7l38iZb
E.Pineiro o1.5 FGs Made-115
0.87u
@EvanHAbrams https://myaction.app/1o1Q7l38iZb
Invisible Insider
Last 30d: 15-16-0 (-2.7u)
J.Taylor 110+ Rushing Yards Yes+145
0.5u
SF -2.5 (1H)-125
1u
Brandon Kravitz
Last 30d: 75-79-2 (+5.6u)
P.Rivers u0.5 Rush Yds-175
1u
Rivers hasn’t had a rushing yard since September 20th 2020…
Anders
Last 30d: 22-13-0 (+8.1u)
IND +6.5-110
2.2u
2U POD Sent a few Days ago… Be Patient for a 6 with it being at 5.5 in a deadzone currently
Brandon Anderson
Last 30d: 53-134-4 (-14.4u)
IND +245
0.5u
MNF pick on Action Network pod
Top Shelf Action 🥃
Last 30d: 76-93-1 (-6.2u)
Under 46.5-115
1.15u
Extended Rest Unders
Overall: 184-135-6,58% (ROI:11%)
Season:13-10-1,57% (ROI:8%)
SNF and MNF Unders
Overall: 98-58-2,63% (ROI:21%)
Season:4-6-0,40% (ROI:-23%)
Night Unders
Overall: 204-140-5,59% (ROI:14%)
Season:15-8-0,65% (ROI:24%)
Primetime Unders
Overall: 187-123-6,60% (ROI:16%)
Season:9-9-1,50% (ROI:-4%)
Night Time Unders
Overall: 149-83-2,64% (ROI:23%)
Season:16-11-1,59% (ROI:12%)
Cam Is Money
Last 30d: 118-102-4 (+3.9u)
M.Pittman o31.5 Rec Yds-114
0.88u
Roger Goodell
Last 30d: 38-53-1 (-12.3u)
SF -2.5 (1H)-120
0.83u
Sandy Plashkes
Last 30d: 104-135-1 (-45.7u)
A.Pierce o20.5 Rec Yds-114
1u
Brandon Kravitz
Last 30d: 75-79-2 (+5.6u)
IND +5.5+110
0.91u
Found a +110 on Bettor Edge, already have the 49ers in a teaser, so I’ll be hoping for that sweet sweet middle.
Gilles Gallant
Last 30d: 26-71-0 (+2.0u)
T.Warren Anytime TD Scorer Yes+280
0.5u
J.Jennings Anytime TD Scorer Yes+170
1.28u
TAN Pod Touchdown Show
Last 30d: 41-123-5 (+3.0u)
J.Jennings Anytime TD Scorer Yes+150
0.75u
@ChrisRaybon https://myaction.app/yPjwhrUIeZb
T.Warren Anytime TD Scorer Yes+250
0.5u
@GDAWG5000 https://myaction.app/yPjwhrUIeZb
M.Pittman Anytime TD Scorer Yes+360
0.5u
@The_Oddsmaker https://myaction.app/yPjwhrUIeZb
Derek Carty
Last 30d: 6-7-1 (+0.3u)
M.Pittman o3.5 Recs+112
1.12u
THE BLITZ is forecasting 5.42 receptions for Michael Pittman. The oddsmakers' implied projection is 3.70 receptions, so I believe there is some value here. If you take the over, you’d be projected to win 72% of the time resulting in a 52% ROI with expected value of $51.79 (based on a $100 wager). This play is good down to at least -165. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
J.Taylor u2.5 Recs+152
1u
There is a value opportunity on Jonathan Taylor's receptions prop. THE BLITZ is projecting him to record 2.37 receptions, while sportsbooks imply 3.68. The model believes there is a 60% chance he records fewer than 2.5 receptions, so there is some value on the under at +152. This play is good down to at least -111. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
A.Pierce o18.5 Rec Yds-114
1u
There is a value opportunity on Alec Pierce's receiving yards prop. THE BLITZ is projecting 61.53 receiving yards for him with a 87% chance that he exceeds 18.5 receiving yards. If you can get the over at -114 or better, there is some great value here. This play is good down to at least -315. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
The Favorites Podcast
Last 30d: 24-32-0 (-1.3u)
SF -5.5-115
1u
@KendraMiddleton_ https://myaction.app/zTMJHWgedZb
Kenny Ducey
Last 30d: 12-17-1 (-6.7u)
Over 46.5-110
1u
Sandy Plashkes
Last 30d: 104-135-1 (-45.7u)
P.Rivers o17.5 Pass Comp-116
1u
Kendra Middleton
Last 30d: 18-12-0 (+6.4u)
SF -3-110
0.91u
Stuck 🚨
Last 30d: 50-48-2 (+0.6u)
IND +6-105
0.5u
Derek Carty
Last 30d: 6-7-1 (+0.3u)
P.Rivers o16.5 Pass Comp-105
1u
THE BLITZ is forecasting 22.73 completions for Philip Rivers. The oddsmakers' implied projection is 17.15 completions, so I believe there is some value here. If you take the over, you’d be projected to win 81% of the time resulting in a 58% ROI with expected value of $61.40 (based on a $100 wager). This play is good down to at least -240. Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
Top Shelf Action 🥃
Last 30d: 76-93-1 (-6.2u)
Under 45.5-105
0.5u
SNF and MNF Unders
Overall: 98-58-2,63% (ROI:21%)
Season:4-6-0,40% (ROI:-23%)
Primetime Unders
Overall: 186-122-6,60% (ROI:16%)
Season:8-8-1,50% (ROI:-4%)
Night Unders
Overall: 204-140-5,59% (ROI:14%)
Season:15-8-0,65% (ROI:24%)
Extended Rest Unders
Overall: 183-135-6,58% (ROI:11%)
Season:12-10-1,55% (ROI:
49ers vs. Colts Previews & Analysis
49ers vs. Colts Props
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Colts Public Betting Percentages
Betting Trends
- Colts are 4-1 in their last 5 games.
- Colts are 3-2 in their last 5 games against the spread
- Colts are 4-3 in their road games against the spread
- The totals have gone OVER in 2 of Colts' last 5 games
- The totals have gone OVER in 4 of Colts' 7 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Colts Injury Updates

49ers Injuries
- George KittleTE
Kittle is questionable with ankle
Questionable
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Ricky PearsallWR
Pearsall is doubtful with ankle
Doubtful
- Jacob CowingWR
Cowing is out with hamstring
Out

Colts Injuries
- Ashton DulinWR
Dulin is out with hamstring
Out
- Daniel JonesQB
Jones is out with achilles
Out
Team Stats
49ers vs. Colts Odds Comparison
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49ers at Colts Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 11-4 | o25.5-120 | u25.5-105 |
Colts 8-7 | o20.5-105 | u20.5-120 |




