Titans vs 49ers Odds & Live Scores - December 14, 2025

MatchupOpenSpreadTotalMoneyline
Titans 3-12	+12.5	+12.5-108	o44.5-112	+610
49ers 11-4	u42.5	-12.5-112	u44.5-115	-900

SF -12.5-105

0.48u

Boomer’s Book

T.Spears o19.5 Rec Yds-118

0.75u

B.Robinson Anytime TD Scorer Yes+300

0.1u

B.Robinson o28.5 Rush Yds-115

0.25u

SF -12.5-111

1u

C.Ward o196.5 Pass Yds-115

1u

SF -12.5-110

1u

J.Jennings Anytime TD Scorer Yes+200

1u

C.McCaffrey 2+ TDs Yes+170

0.5u

The poor Titans are now 0-10 against current top-eight seeds, losing by an average of 14.9 PPG. They're 2-1 in all other games, but it's another tough game here with the 49ers coming off their bye and looking like they should be able to name their score. A Christian McCaffrey touchdown feels like a free space. The Titans have allowed 14 rushing touchdowns, third most in the NFL, with at least one TD to all but three opposing RB1s. McCaffrey has at least one touchdown in 9-of-13 games, but at -275 for an Anytime TD, the juice may not be worth the squeeze. I'll jump straight to 2+TDs at +170 (bet365). McCaffrey has at least two scores in three of the last five 49ers wins. He's become this entire offense. Touch 3+ TDs at +650 too. If McCaffrey does have another big game against these Titans, he could find himself in the mix for Offensive Player of the Year. I wrote in the Extra Point in this week's Pick Six about why I'm betting McCaffrey at +2500 to win OPOY too (FanDuel).

C.McCaffrey 3+ TDs Yes+700

0.15u

The poor Titans are now 0-10 against current top-eight seeds, losing by an average of 14.9 PPG. They're 2-1 in all other games, but it's another tough game here with the 49ers coming off their bye and looking like they should be able to name their score. A Christian McCaffrey touchdown feels like a free space. The Titans have allowed 14 rushing touchdowns, third most in the NFL, with at least one TD to all but three opposing RB1s. McCaffrey has at least one touchdown in 9-of-13 games, but at -275 for an Anytime TD, the juice may not be worth the squeeze. I'll jump straight to 2+TDs at +170 (bet365). McCaffrey has at least two scores in three of the last five 49ers wins. He's become this entire offense. Touch 3+ TDs at +650 too. If McCaffrey does have another big game against these Titans, he could find himself in the mix for Offensive Player of the Year. I wrote in the Extra Point in this week's Pick Six about why I'm betting McCaffrey at +2500 to win OPOY too (FanDuel).

SF -12.5-110

0.91u

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B.Purdy o7.5 Rush Yds-114

0.88u

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T.Pollard o11.5 Rush Att-138

0.72u

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C.McCaffrey 2+ TDs Yes+170

0.59u

@wheatonbrando https://myaction.app/WY2kO2TT2Yb

C.McCaffrey 3+ TDs Yes+650

0.15u

@wheatonbrando https://myaction.app/WY2kO2TT2Yb

J.Jennings Anytime TD Scorer Yes+190

0.95u

@ChrisRaybon https://myaction.app/Se0f2bFP2Yb

G.Helm Anytime TD Scorer Yes+475

2.38u

@ChrisRaybon https://myaction.app/Se0f2bFP2Yb

SF -12.5-115

1u

#PlantYourFlag @BKPicks https://myaction.app/Mvm5aK5YXYb

SF -12.5-111

1.35u

SF -12.5-110

1.36u

Niners off the bye…Minor travel advantage with a central time-zone team flying out west. Robert Saleh with extra time to prep for Cam Ward who has been awful this season. He was outplayed by Shedeur Sanders last week, albeit in a win. 49ers #2 in 3rd down conversion %...#2 on special teams…they have been so much better this season than many of us have given them credit for. I know laying big numbers in the NFL is a tough pill to swallow, but I think the Niners are worth the plunge.

SF -13.5-111

1u

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NFL Public Betting

49ers are 2-3 in their last 5 games.
49ers are 2-3 in their last 5 games against the spread
49ers are 7-2 in their road games against the spread
The totals have gone OVER in 3 of 49ers' last 5 games
The totals have gone OVER in 3 of 49ers' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	10-5	3-3	7-2	8-2	2-3
Titans	7-8	4-4	3-4	N/A	7-8

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	9-6	3-3	6-3	6-4	3-2
Titans	9-6	5-3	4-3	N/A	9-6

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	11-4	N/A	N/A	9-1	2-3
Titans	3-12	N/A	N/A	N/A	3-12

date	opponent	score	spread	over/under	moneyline
Nov 30th	@CLE	W 26-8	-5.5 W	U 35.5	SF -250
Nov 25th	CAR	W 20-9	-7.5 W	U 49	SF -375
Nov 16th	@ARI	W 41-22	-3.5 W	O 48.5	SF -192
Nov 9th	LA	L 26-42	+5.5 L	O 49.5	LA +212
Nov 2nd	@NYG	W 34-24	-2.5 W	O 47.5	SF -146

George Kittle
TE
Kittle is out with ankle
Out
Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Calvin Ridley
WR
Ridley is out with leg
Out
Bryce Oliver
WR
Oliver is out with knee
Out

See more NFL Injuries

Titans

Total

49ers

306

Total Yards

430

49

Total Plays

70

6.2

Yards Per Play

6.1

Titans

Passing

49ers

170

YDS

295

18/29

Comps/Atts

23/30

5.862

YPA

9.125

2/0

TDs/INTs

3/0

0/0

Sacks/Yards

2/3

Titans

Rushing

49ers

136

Rush Yards

138

20

Attempts

38

6.8

YPC

3.632

1

TDs

1

Titans

Turnovers

49ers

0

Fumbles Lost

1

0

Interceptions

0

Titans

Efficiency

49ers

2/3 66.67%

Redzone

4/6 66.67%

3/9 0%

3rd Down

9/15 0%

2/2 0%

4th Down

1/1 0%

Titans

First Downs

49ers

18

Total

28

8

Pass

18

9

Rush

7

1

Penalty

3

Titans

Misc

49ers

7/57

Penalties/Yards

6/30

22:55

Possession

37:05

MatchupOverUnder
Titans 3-12	o15.5-122	u15.5+102
49ers 11-4	o29.5-110	u29.5-110

Titans vs. 49ers Odds & Betting Predictions - December 14, 2025

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