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Louisville Cardinals Odds

Next Louisville Game

Game Details
vs James Madison Dukes
James Madison
location pin
Fri 9/0511:00 PM

Louisville vs JMU Odds

More Odds
SpreadTotalMoneyline
JMU
+14.5-110
o55.5-108
+450
LOU
-14.5-110
u55.5-112
-650

Cardinals Injuries

All NCAAF Injuries

There are no injuries for this team currently.

Picks
Brian Bitler
Brian Bitler
Last 30d: 12-7-0 (+12.4u)
4
Firefighter Bets
Firefighter Bets
Last 30d: 16-13-0 (+1.9u)
JMU +14.5-130
JMU
JMU Team Abbreviation@LOU Team Abbreviation
LOU
1u
09/05 11:00 PM
BBOC G5 Deep Dive Pod
BBOC G5 Deep Dive Pod
Last 30d: 11-5-0 (+6.0u)
JMU +14.5-110
JMU
JMU Team Abbreviation@LOU Team Abbreviation
LOU
1u
09/05 11:00 PM
@Breese Best Bet 1
6
Collin Wilson
Collin Wilson
Last 30d: 24-17-2 (+3.5u)
Over 58.5-110
JMU
JMU Team Abbreviation@LOU Team Abbreviation
LOU
1.1u
09/05 11:00 PM
195
Duck
Duck
Last 30d: 36-11-0 (+15.4u)
JMU +14.5-115
JMU
JMU Team Abbreviation@LOU Team Abbreviation
LOU
1u
09/05 11:00 PM
178
Mike Calabrese
Mike Calabrese
Last 30d: 9-8-0 (+4.1u)
JMU +14.5-108
JMU
JMU Team Abbreviation@LOU Team Abbreviation
LOU
1.75u
09/05 11:00 PM
Bob Chesney is not only a winner, but a guy who doesn’t get blown out. In his last 46 games as a head coach, he’s lost by more than 14 points one time. And that came at South Dakota State in the FCS Playoffs, the Jackrabbits won the FCS Natty that year. That’s a long, long run of being prepared when you’re playing up, playing down, sandwich spots, lookaheads, there are no traps with Chesney at the helm. #GoDukes 🟣🐶
65

Cardinals 2025 Schedule & Betting Odds

dateopponentscorespreadover/undermoneyline
Sep 27th@PITT----
Sep 20thBGSU----
Sep 5thJMU----
Aug 30thEKUW 51-17-38.5 LO 56.5LOU -4875
News

Louisville Cardinals Football

The Louisville Cardinals are headed by Coach Jeff Brohm, leading the team to a successful season after just 2 years with the team. The Cardinals finished with a 9-4 record, with a 35-35 win in the Sun Bowl. 

The team will play Eastern Kentucky Colonels on August 30th at the L&N Stadium before taking on the James Madison Dukes.

Louisville Cardinals Point Spreads

Here’s an example of a past Cards game vs. Pittsburgh point spread.

  • Louisville +3 (-110)
  • Pittsburgh -3 (-110)

The Cardinals lost the game, 23-20, making the bet a tie or a push. This means bettors on either side got their money back. For Cardinals bets to have won, they would’ve needed to win the game or lose by one or two points. Pittsburgh backers would have needed a win by four or more for their bets to cash.

Louisville Cardinals Over/Unders

Another popular bet that can be made on college football games is an over/under or total bet. With these bets, neither the winner of the game nor the winning margin matters. Instead, you’re betting on the combined scoring of the teams.

Using their game against Georgia Tech as an example, books set the total at 54. The game finished 39-34 for Tech for a combined 73 points. This was a winner for anyone who bet the over. Had the teams combined for fewer than 63 points, under bets would have cashed; if it landed at exactly 63, both sides would've gotten their stake back.

Louisville Cardinals Moneylines

Another common college football bet is a moneyline bet. Instead of handicapping a team by a certain number of points, oddsmakers adjust the payout based on the chances either team has of winning.

Moneyline bets are easiest to understand if you think in units of $100. Were the Cardinals to defeat Georgia Tech as +150 underdogs, a $100 bet would profit $150. Had they been -150 favorites instead, you’d need to bet $150 to have a chance at a $100 return.

Louisville Cardinals Props

If you have a favorite Cardinal and want to bet on his stats for the game, look at proposition, or prop, bets. Like over/unders, prop bets are bets on whether more or less of something will happen than the books are expecting.

College football player props are far less common than NFL ones, so make sure to find a sportsbook that offers them.

Louisville Cardinals Futures

You can also bet on a variety of end-of-season results for the Cardinals. These are called futures bets.

Some Cardinals futures bets available include, among others, their odds to win the ACC, win the national title, or go over a certain number of wins for the season. These bets are priced like moneylines to reflect how likely they are to happen.

Next Louisville Game

Game Details
vs James Madison Dukes
James Madison
location pin
Fri 9/0511:00 PM

Louisville vs JMU Odds

More Odds
SpreadTotalMoneyline
JMU
+14.5-110
o55.5-108
+450
LOU
-14.5-110
u55.5-112
-650

Cardinals Injuries

All NCAAF Injuries

There are no injuries for this team currently.

Louisville Cardinals Football

The Louisville Cardinals are headed by Coach Jeff Brohm, leading the team to a successful season after just 2 years with the team. The Cardinals finished with a 9-4 record, with a 35-35 win in the Sun Bowl. 

The team will play Eastern Kentucky Colonels on August 30th at the L&N Stadium before taking on the James Madison Dukes.

Louisville Cardinals Point Spreads

Here’s an example of a past Cards game vs. Pittsburgh point spread.

  • Louisville +3 (-110)
  • Pittsburgh -3 (-110)

The Cardinals lost the game, 23-20, making the bet a tie or a push. This means bettors on either side got their money back. For Cardinals bets to have won, they would’ve needed to win the game or lose by one or two points. Pittsburgh backers would have needed a win by four or more for their bets to cash.

Louisville Cardinals Over/Unders

Another popular bet that can be made on college football games is an over/under or total bet. With these bets, neither the winner of the game nor the winning margin matters. Instead, you’re betting on the combined scoring of the teams.

Using their game against Georgia Tech as an example, books set the total at 54. The game finished 39-34 for Tech for a combined 73 points. This was a winner for anyone who bet the over. Had the teams combined for fewer than 63 points, under bets would have cashed; if it landed at exactly 63, both sides would've gotten their stake back.

Louisville Cardinals Moneylines

Another common college football bet is a moneyline bet. Instead of handicapping a team by a certain number of points, oddsmakers adjust the payout based on the chances either team has of winning.

Moneyline bets are easiest to understand if you think in units of $100. Were the Cardinals to defeat Georgia Tech as +150 underdogs, a $100 bet would profit $150. Had they been -150 favorites instead, you’d need to bet $150 to have a chance at a $100 return.

Louisville Cardinals Props

If you have a favorite Cardinal and want to bet on his stats for the game, look at proposition, or prop, bets. Like over/unders, prop bets are bets on whether more or less of something will happen than the books are expecting.

College football player props are far less common than NFL ones, so make sure to find a sportsbook that offers them.

Louisville Cardinals Futures

You can also bet on a variety of end-of-season results for the Cardinals. These are called futures bets.

Some Cardinals futures bets available include, among others, their odds to win the ACC, win the national title, or go over a certain number of wins for the season. These bets are priced like moneylines to reflect how likely they are to happen.