Guardians vs. Astros Odds & Betting Predictions - June 21, 2026

Guardians at Astros

6:10 pm • CLEG

Cleveland Guardians

@

Houston Astros

pitcher		team	era	w-l
K.Teng			4.31	3-6
S.Cecconi			4.60	3-5

MatchupOpenSpreadTotalMoneyline
Guardians 41-36	+1.5	+1.5-183	o8.5-118	+115
Astros 36-42	u8.5	-1.5+150	u8.5-102	-136

location pin

Sunday 6:10 p.m.

June 21, 2026

Daikin ParkHouston

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85°Fahrenheit

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40%Rain

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10Wind

CLE +116

1u

T.Bazzana o0.5 HR+741

0.1u

T.Bazzana o1.5 Total Bases+141

0.71u

The Leadoff: Minion's 16 Bets for 9 MLB Games on Sunday
Ryan Minion•
Jun 21, 2026 UTC

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MLB Public Betting

Astros are 3-2 in their last 5 games.
Astros are 3-2 in their last 5 games against the spread
Astros are 18-20 in their road games against the spread
The totals have gone OVER in 3 of Astros' last 5 games
The totals have gone OVER in 24 of Astros' 40 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Astros	37-41	19-21	18-20	8-17	28-23
Guardians	41-36	19-17	22-19	18-23	23-13

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Astros	41-33-4	24-15-1	17-18-3	15-10	25-22-4
Guardians	38-39	18-18	20-21	21-20	17-19

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Astros	36-42	19-21	17-21	10-15	25-26
Guardians	41-36	19-17	22-19	22-19	19-17

date	opponent	score	spread	over/under	moneyline
Jun 20th	CLE	L 1-8	-1.5 L	O 8.5	CLE -156
Jun 20th	CLE	W 9-3	-1.5 W	O 8.5	HOU -125
Jun 17th	DET	W 4-2	+1.5 W	U 8.5	HOU -110
Jun 17th	DET	W 4-2	-1.5 W	U 8.5	HOU -175
Jun 16th	DET	L 3-9	-1.5 L	O 9	DET -125

Lance McCullers
SP
Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.
Out

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PITCHER		W-L	ERA	WHIP	K/9
RS.Cecconi, P		3-5	4.60	1.404	7.47

HITTERS	AVG	OBP	SLG	HR
1T.Bazzana, 2B	.274	.369	.476	7
2K.Manzardo, 1B	.238	.328	.413	9
3B.Rocchio, SS	.269	.348	.393	5
4R.Hoskins, DH	.175	.312	.362	7
5D.Schneemann, 3B	.218	.291	.358	6
6K.Watson, RF	.000	.000	.000	0
7S.Kwan, LF	.207	.318	.253	1
8P.Bailey, C	.230	.262	.361	1
9P.Halpin, CF	.158	.179	.184	0

PITCHER		W-L	ERA	WHIP	K/9
RK.Teng, P		3-6	4.31	1.344	9.61

HITTERS	AVG	OBP	SLG	HR
1J.Pena, SS	.284	.345	.452	6
2Y.Alvarez, DH	.320	.424	.630	24
3C.Walker, 1B	.240	.313	.484	18
4I.Paredes, 3B	.238	.342	.413	10
5J.Altuve, 2B	.239	.313	.407	8
6Y.Diaz, C	.243	.265	.351	2
7C.Smith, RF	.222	.303	.358	7
8J.Loperfido, LF	.250	.356	.342	0
9J.Meyers, CF	.210	.269	.328	3

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MatchupOverUnder
Guardians 41-36	N/A	N/A
Astros 36-42	N/A	N/A