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Guardians vs. Athletics Odds & Betting Predictions - June 22, 2025

Guardians at Athletics

2:05 am • NBCS-CA

Cleveland Guardians

6-4
4
4 - 2

Athletics

3-6
2
Starting Pitchers
pitcherteameraw-l
Mitch Spence logoM.SpenceAthletics logo5.103-6
Luis L. Ortiz logoL.OrtizCleveland Guardians logo4.374-9

Guardians at Athletics Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
6-4
-1.5
-1.5+118
o9.5+101
-135
Athletics
3-6
u9.5
+1.5-143
u9.5-123
+114
location pinSunday 2:05 a.m.
June 22, 2025
Sutter Health ParkWest Sacramento
Guardians vs. Athletics Expert Picks
Cam Is Money
Cam Is Money
Last 30d: 83-65-4 (+9.4u)
Over 9.5-103
2u
Kyle Murray
Kyle Murray
Last 30d: 71-131-7 (-9.3u)
M.Spence o4.5 Ks+106
1u
Grant Neiffer
Grant Neiffer
Last 30d: 9-51-0 (+3.8u)
N.Kurtz o0.5 HR+450
0.25u
Picks Office
Picks Office
Last 30d: 189-199-6 (-23.8u)
CLE -120
0.83u
Follow @PicksOffice on X to read the full writeup.
Boomer Betz
Boomer Betz
Last 30d: 100-83-2 (+35.6u)
M.Spence o2.5 Earned Runs+117
1.17u
Sean Zerillo
Sean Zerillo
Last 30d: 138-135-4 (+3.9u)
ATH +104
0.5u
Bet to -110
Matt Trollo
Matt Trollo
Last 30d: 11-10-2 (-0.1u)
ATH -108 (F5)
0.54u
Spencer 2.88 Bot ERA/116 Pitching+ three starts, Ortiz 11.8 BB%, 10% Barrels/BBE, 49 HardHit% - A's 115/109/111 wRC+ Hm/v RHP/L7days, CLE 90/97/54
ATH +100
0.5u
See notes F5

Guardians vs. Athletics Previews & Analysis

  • Guardians vs. Athletics: The PRO Model Play article feature image

    Guardians vs. Athletics: The PRO Model Play

    Alex Kolodziej•
    Jun 21, 2025 UTC
  • Neiffer's Home Run Prop Bets for Saturday article feature image

    Neiffer's Home Run Prop Bets for Saturday

    Grant Neiffer•
    Jun 21, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Athletics Public Betting Percentages

Away Logo

Guardians

Public

Home Logo

Athletics

54%

Bets%

46%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Athletics are 3-2 in their last 5 games.
  • Athletics are 3-2 in their last 5 games against the spread
  • Athletics are 3-3 in their road games against the spread
  • The totals have gone OVER in 3 of Athletics' last 5 games
  • The totals have gone OVER in 3 of Athletics' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Athletics		5-42-13-30-14-3
Guardians		7-33-04-31-06-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Athletics		4-53-01-51-02-5
Guardians		4-61-23-40-14-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Athletics		3-62-11-50-12-5
Guardians		6-42-14-31-05-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 21stCLEW 5-1+1.5 WU 9ATH +105
Jun 20thHOUW 6-4+1.5 WU 10ATH +122
Jun 19thHOUL 4-11+1.5 LO 9.5HOU +152
Jun 18thHOUL 3-13+1.5 LO 11HOU +107
Jun 17thHOUW 3-1+1.5 WU 9.5ATH -106

Guardians vs. Athletics Injury Updates

Guardians Injuries

    Athletics Injuries

    • Gunnar Hoglund
      SP

      Hoglund is out with back

      Out

    See more MLB Injuries Right Arrow
    Guardians vs. Athletics Box Score
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Luis L. Ortiz logoRL.Ortiz, P926100
    Cade Smith logoRC.Smith, P23121
    Hunter Gaddis logoRH.Gaddis, P9111
    Emmanuel Clase logoRE.Clase, P12100
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF3-5101
    Kyle Manzardo logo2K.Manzardo, DH2-5000
    Jose Ramirez logo3J.Ramirez, 3B3-4001
    Carlos Santana logo4C.Santana, 1B0-5000
    Daniel Schneemann logo5D.Schneemann, SS0-5000
    Nolan Jones logo6N.Jones, CF0-2100
    Lane Thomas logo6L.Thomas, PH0-0000
    Lane Thomas logo6L.Thomas, CF0-0000
    Bo Naylor logo7B.Naylor, C1-3101
    David Fry logo7D.Fry, PH0-1000
    Austin Hedges logo7A.Hedges, C0-0000
    Johnathan Rodriguez logo8J.Rodriguez, RF1-4101
    Angel Martinez logo9A.Martinez, 2B0-4000
    Athletics Player Stats
    Projected
    PITCHERPCIPKER
    Mitch Spence logoRM.Spence, P854.234
    T.J. McFarland logoLT.McFarland, P50.110
    Sean Newcomb logoLS.Newcomb, P34220
    Hogan Harris logoLH.Harris, P38240
    HITTERSH-ABRHRRBI
    Lawrence Butler logo1L.Butler, RF0-3000
    Denzel Clarke logo1D.Clarke, CF0-1000
    Jacob Wilson logo2J.Wilson, SS0-4000
    Brent Rooker logo3B.Rooker, LF1-3100
    Brent Rooker logo3B.Rooker, RF1-3100
    Nick Kurtz logo4N.Kurtz, DH0-3000
    Max Muncy logo5M.Muncy, 3B0-3001
    Tyler Soderstrom logo6T.Soderstrom, 1B1-4000
    JJ Bleday logo7J.Bleday, CF0-3100
    JJ Bleday logo7J.Bleday, LF0-3100
    Urias logo8L.Urias, 2B2-4000
    Austin Wynns logo9A.Wynns, C1-4001

    Guardians vs. Athletics Odds Comparison

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    Guardians at Athletics Team Totals

    MatchupOverUnder
    Guardians
    6-4
    N/A
    N/A
    Athletics
    3-6
    N/A
    N/A