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Guardians vs. Red Sox Odds & Betting Predictions - September 3, 2025

Guardians at Red Sox

10:45 pm • NESN

Cleveland Guardians

15-12
8
8 - 1

Boston Red Sox

9-17
1
Starting Pitchers
pitcherteameraw-l
Brennan Bernardino logoB.BernardinoBoston Red Sox logo3.144-3
Joey Cantillo logoJ.CantilloCleveland Guardians logo3.215-3

Guardians at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
15-12
+1.5
+1.5-164
o8.5-122
+123
Red Sox
9-17
u9
-1.5+137
u8.5-104
-150
location pinWednesday 10:45 p.m.
September 03, 2025
Fenway ParkBoston
Guardians vs. Red Sox Expert Picks
Wags Wins
Wags Wins
Last 30d: 239-263-2 (-8.5u)
CLE +130
1.3u
Allan Lem
Allan Lem
Last 30d: 53-42-0 (+1.0u)
Under 9+100
0.5u
Doug Ziefel
Doug Ziefel
Last 30d: 291-380-23 (-21.9u)
BOS -141
0.71u
Sean Zerillo
Sean Zerillo
Last 30d: 174-171-13 (-10.7u)
Over 9+100
0.5u
Bet to -115
Matt Trollo
Matt Trollo
Last 30d: 51-54-7 (-4.0u)
BOS -138 (F5)
0.5u
Starters are comparable, but BOS large defensive edge + CLE 80/75/57 wRC+ Rd/v LHP/L7 days, BOS 104/106/106

Prop Odds Comparison

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No props found

Line Movement Tracker

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Guardians vs. Red Sox Public Betting Percentages

Away Logo

Guardians

Public

Home Logo

Red Sox

16%

Bets%

84%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Red Sox are 1-4 in their last 5 games.
  • Red Sox are 1-4 in their last 5 games against the spread
  • Red Sox are 4-9 in their road games against the spread
  • The totals have gone OVER in 2 of Red Sox' last 5 games
  • The totals have gone OVER in 4 of Red Sox' 13 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox		7-193-104-97-130-6
Guardians		16-119-47-78-58-6

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox		13-134-99-410-103-3
Guardians		14-136-78-67-67-7

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox		9-175-84-99-110-6
Guardians		15-128-57-78-57-7

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 2ndCLEW 11-7-1.5 WO 7.5BOS -255
Sep 1stCLEW 6-4-1.5 WO 8BOS -146
Aug 31stPITW 5-2-1.5 WU 8.5BOS -175
Aug 30thPITL 3-10-1.5 LO 9PIT -188
Aug 29thPITL 2-4+1.5 LU 8PIT -118

Red Sox vs. Guardians Injury Updates

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Patrick Sandoval
    SP

    Sandoval is out with elbow

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

  • Romy Gonzalez
    1B

    Gonzalez is out with shoulder

    Out

Guardians Injuries

  • Steven Kwan
    LF

    Steven Kwan scratched Saturday

    Out

See more MLB Injuries Right Arrow
Guardians vs. Red Sox Box Score
Guardians Player Stats
Projected
PITCHERPCIPKER
Joey Cantillo logoLJ.Cantillo, P104671
Jakob Junis logoRJ.Junis, P291.220
Erik Sabrowski logoLE.Sabrowski, P191.110
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, LF3-5201
Angel Martinez logo2A.Martinez, CF1-4000
Jose Ramirez logo3J.Ramirez, 3B0-3102
Kyle Manzardo logo4K.Manzardo, DH0-4000
Jhonkensy Noel logo5J.Noel, RF0-5000
Bo Naylor logo6B.Naylor, C2-4200
Gabriel Arias logo7G.Arias, SS1-3112
George Valera logo7G.Valera, PH1-1000
Daniel Schneemann logo7D.Schneemann, 2B0-0000
CJ Kayfus logo8C.Kayfus, 1B2-3101
Brayan Rocchio logo9B.Rocchio, 2B1-4100
Brayan Rocchio logo9B.Rocchio, SS1-4100
Red Sox Player Stats
Projected
PITCHERPCIPKER
Brennan Bernardino logoLB.Bernardino, P170.201
Jordan Hicks logoRJ.Hicks, P160.114
Steven Matz logoLS.Matz, P14101
Zack Kelly logoRZ.Kelly, P63440
Dustin May logoRD.May, P53311
HITTERSH-ABRHRRBI
Nate Eaton logo1N.Eaton, 3B1-3000
Nathaniel Lowe logo1N.Lowe, PH0-1000
Nathaniel Lowe logo1N.Lowe, 1B0-1000
Alex Bregman logo2A.Bregman, DH0-4000
Trevor Story logo3T.Story, SS0-3000
David Hamilton logo3D.Hamilton, PH0-1000
David Hamilton logo3D.Hamilton, SS0-1000
Romy Gonzalez logo4R.Gonzalez, 1B2-4000
Romy Gonzalez logo4R.Gonzalez, 2B2-4000
Rob Refsnyder logo5R.Refsnyder, RF1-3100
Jarren Duran logo6J.Duran, LF1-3000
Ceddanne Rafaela logo7C.Rafaela, CF0-4000
Nick Sogard logo8N.Sogard, 2B1-4001
Nick Sogard logo8N.Sogard, 3B1-4001
Connor Wong logo9C.Wong, C1-3000
Ali Sanchez logo9A.Sanchez, C0-1000

Guardians vs. Red Sox Odds Comparison

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Guardians at Red Sox Team Totals

MatchupOverUnder
Guardians
15-12
N/A
N/A
Red Sox
9-17
N/A
N/A