Guardians vs. Tigers Odds & Betting Predictions - May 21, 2026

Guardians at Tigers

5:10 pm • CLEG
3 - 1
Starting Pitchers
pitcherteameraw-l
Casey Mize logoC.MizeDetroit Tigers logo2.582-4
Joey Cantillo logoJ.CantilloCleveland Guardians logo4.056-3

Guardians at Tigers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
41-38
-1.5
+1.5-205
o7.5+100
+110
Tigers
34-44
u7.5
-1.5+170
u7.5-120
-130
location pinThursday 5:10 p.m.
May 21, 2026
Comerica ParkDetroit
Guardians vs. Tigers Expert Picks
Brandon Kravitz
Brandon Kravitz
Last 30d: 55-49-0 (+10.1u)
Under 7.5 (Live)+110
1.1u
For logging purposes only, didn’t realize this had been fulfilled on the exchanges.
The Propfessor
The Propfessor
Last 30d: 28-41-0 (+12.6u)
DET -120 (F5)
0.85u
Wags Wins
Wags Wins
Last 30d: 157-146-0 (-8.2u)
DET -117
1.25u
💰🦡 Jake
💰🦡 Jake
Last 30d: 61-85-2 (-16.8u)
C.Mize o16.5 Outs-113
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 35-19-0 (+4.7u)
Under 7.5-122
0.41u
Frank Ammirante
Frank Ammirante
Last 30d: 320-265-11 (+57.1u)
DET -120
1.2u
Under 4 (F5)-125
1u
Kyle Murray
Kyle Murray
Last 30d: 67-112-1 (-32.5u)
DET -124 (F5)
1.24u
Ryan Minion
Ryan Minion
Last 30d: 276-270-14 (+60.6u)
J.Ramirez o1.5 Hits + Runs + RBIs-123
$1.00
J.Ramirez o1.5 Total Bases+117
$1.00
Adam Kaufman
Adam Kaufman
Last 30d: 83-99-0 (-31.6u)
CLE +105
1.05u
Sean Zerillo
Sean Zerillo
Last 30d: 148-125-9 (+4.4u)
DET -110
0.55u
Bet to -120
Under 7.5-114
0.5u
Bet to -122
Doug Ziefel
Doug Ziefel
Last 30d: 160-188-11 (-4.2u)
Under 7.5-112
0.5u

Guardians vs. Tigers Previews & Analysis

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    Our 3 MLB Best Bets for Thursday Night

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    The Leadoff: Trollo's MLB Breakdown and Bets for Thursday

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Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Tigers Public Betting Percentages

Away Logo

Guardians

Public

55%

Bets%

45%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Tigers
38-4123-1615-2518-2320-15
Guardians
42-3819-1723-2118-2424-13

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Tigers
34-42-316-21-218-21-119-20-214-20-1
Guardians
39-4118-1821-2321-2117-20

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Tigers
34-4522-1712-2821-2013-22
Guardians
41-3919-1722-2222-2019-18

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 20thCLEL 2-3+1.5 WU 7.5CLE +102
May 19thCLEL 3-4+1.5 WU 8CLE +135
May 18thCLEL 2-8-1.5 LO 8CLE -156
May 17thTORL 1-4+1.5 LU 7.5TOR -102
May 16thTORL 1-2+1.5 WU 8TOR -115

Guardians vs. Tigers Injury Updates

Guardians Injuries

    Tigers Injuries

    • Reese Olson
      SP

      Olson is out with shoulder

      Out

    • Jackson Jobe
      SP

      Jobe is out with elbow

      Out

    • Trey Sweeney
      SS

      Sweeney is out with shoulder

      Out

    • Sawyer Gipson-Long
      SP

      Gipson-Long is out with oblique

      Out

    • Beau Brieske
      RP

      Brieske is out with groin

      Out

    Guardians vs. Tigers Box Score
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Joey Cantillo logoLJ.Cantillo, P985.260
    Matt Festa logoRM.Festa, P50.110
    Shawn Armstrong logoRS.Armstrong, P160.220
    Tim Herrin logoLT.Herrin, P100.211
    Codi Heuer logoRC.Heuer, P90.210
    Hunter Gaddis logoRH.Gaddis, P16120
    HITTERSH-ABRHRRBI
    Daniel Schneemann logo1D.Schneemann, 3B1-3101
    Jose Ramirez logo2J.Ramirez, DH1-4001
    Chase DeLauter logo3C.DeLauter, RF0-4000
    Rhys Hoskins logo4R.Hoskins, 1B0-4000
    Travis Bazzana logo5T.Bazzana, 2B0-4000
    Angel Martinez logo6A.Martinez, LF0-4000
    Steven Kwan logo7S.Kwan, CF0-4000
    Patrick Bailey logo8P.Bailey, C1-3111
    Brayan Rocchio logo9B.Rocchio, SS3-3100
    Tigers Player Stats
    Projected
    PITCHERPCIPKER
    Casey Mize logoRC.Mize, P956.242
    Burch Smith logoRB.Smith, P270.211
    Enmanuel De Jesus logoLE.De Jesus, P251.220
    HITTERSH-ABRHRRBI
    Matt Vierling logo1M.Vierling, CF0-4000
    Kevin McGonigle logo2K.McGonigle, 3B1-3000
    Kevin McGonigle logo2K.McGonigle, SS1-3000
    Dillon Dingler logo3D.Dingler, C2-4111
    Riley Greene logo4R.Greene, LF0-4000
    Jahmai Jones logo5J.Jones, DH0-2000
    Gage Workman logo5G.Workman, PH0-1000
    Gage Workman logo5G.Workman, DH0-1000
    Spencer Torkelson logo6S.Torkelson, 1B1-4000
    Wenceel Perez logo7W.Perez, RF0-4000
    Hao-Yu Lee logo8H.Lee, 2B0-2000
    Colt Keith logo8C.Keith, PH0-1000
    Colt Keith logo8C.Keith, 3B0-1000
    Zack Short logo9Z.Short, SS1-2000
    Zach McKinstry logo9Z.McKinstry, PH1-2000
    Zach McKinstry logo9Z.McKinstry, 2B1-2000

    Guardians vs. Tigers Odds Comparison

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    Guardians at Tigers Team Totals

    MatchupOverUnder
    Guardians
    41-38
    N/A
    N/A
    Tigers
    34-44
    N/A
    N/A