Guardians vs. Tigers Odds & Betting Predictions - May 21, 2026

Guardians at Tigers

5:10 pm • CLEG

Cleveland Guardians

41-38

3 - 1

Detroit Tigers

34-44

pitcher		team	era	w-l
C.Mize			2.58	2-4
J.Cantillo			4.05	6-3

MatchupOpenSpreadTotalMoneyline
Guardians 41-38	-1.5	+1.5-205	o7.5+100	+110
Tigers 34-44	u7.5	-1.5+170	u7.5-120	-130

Thursday 5:10 p.m.

May 21, 2026

Comerica ParkDetroit

Under 7.5 (Live)+110

1.1u

For logging purposes only, didn’t realize this had been fulfilled on the exchanges.

DET -120 (F5)

0.85u

DET -117

1.25u

C.Mize o16.5 Outs-113

Under 7.5-122

0.41u

DET -120

1.2u

Under 4 (F5)-125

DET -124 (F5)

1.24u

J.Ramirez o1.5 Hits + Runs + RBIs-123

$1.00

J.Ramirez o1.5 Total Bases+117

$1.00

CLE +105

1.05u

DET -110

0.55u

Bet to -120

Under 7.5-114

0.5u

Bet to -122

Under 7.5-112

0.5u

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No props found

MLB Public Betting

Tigers are 4-1 in their last 5 games.
Tigers are 3-2 in their last 5 games against the spread
Tigers are 15-25 in their road games against the spread
The totals have gone OVER in 1 of Tigers' last 5 games
The totals have gone OVER in 16 of Tigers' 39 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Tigers	38-41	23-16	15-25	18-23	20-15
Guardians	42-38	19-17	23-21	18-24	24-13

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Tigers	34-42-3	16-21-2	18-21-1	19-20-2	14-20-1
Guardians	39-41	18-18	21-23	21-21	17-20

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Tigers	34-45	22-17	12-28	21-20	13-22
Guardians	41-39	19-17	22-22	22-20	19-18

date	opponent	score	spread	over/under	moneyline
May 20th	CLE	L 2-3	+1.5 W	U 7.5	CLE +102
May 19th	CLE	L 3-4	+1.5 W	U 8	CLE +135
May 18th	CLE	L 2-8	-1.5 L	O 8	CLE -156
May 17th	TOR	L 1-4	+1.5 L	U 7.5	TOR -102
May 16th	TOR	L 1-2	+1.5 W	U 8	TOR -115

Reese Olson
SP
Olson is out with shoulder
Out
Jackson Jobe
SP
Jobe is out with elbow
Out
Trey Sweeney
SS
Sweeney is out with shoulder
Out
Sawyer Gipson-Long
SP
Gipson-Long is out with oblique
Out
Beau Brieske
RP
Brieske is out with groin
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LJ.Cantillo, P	98	5.2	6	0
RM.Festa, P	5	0.1	1	0
RS.Armstrong, P	16	0.2	2	0
LT.Herrin, P	10	0.2	1	1
RC.Heuer, P	9	0.2	1	0
RH.Gaddis, P	16	1	2	0

HITTERS	H-AB	R	HR	RBI
1D.Schneemann, 3B	1-3	1	0	1
2J.Ramirez, DH	1-4	0	0	1
3C.DeLauter, RF	0-4	0	0	0
4R.Hoskins, 1B	0-4	0	0	0
5T.Bazzana, 2B	0-4	0	0	0
6A.Martinez, LF	0-4	0	0	0
7S.Kwan, CF	0-4	0	0	0
8P.Bailey, C	1-3	1	1	1
9B.Rocchio, SS	3-3	1	0	0

PITCHER	PC	IP	K	ER
RC.Mize, P	95	6.2	4	2
RB.Smith, P	27	0.2	1	1
LE.De Jesus, P	25	1.2	2	0

HITTERS	H-AB	R	HR	RBI
1M.Vierling, CF	0-4	0	0	0
2K.McGonigle, 3B	1-3	0	0	0
2K.McGonigle, SS	1-3	0	0	0
3D.Dingler, C	2-4	1	1	1
4R.Greene, LF	0-4	0	0	0
5J.Jones, DH	0-2	0	0	0
5G.Workman, PH	0-1	0	0	0
5G.Workman, DH	0-1	0	0	0
6S.Torkelson, 1B	1-4	0	0	0
7W.Perez, RF	0-4	0	0	0
8H.Lee, 2B	0-2	0	0	0
8C.Keith, PH	0-1	0	0	0
8C.Keith, 3B	0-1	0	0	0
9Z.Short, SS	1-2	0	0	0
9Z.McKinstry, PH	1-2	0	0	0
9Z.McKinstry, 2B	1-2	0	0	0