Guardians vs. Tigers Odds & Betting Predictions - May 21, 2026
Guardians at Tigers
5:10 pm • CLEGStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 2.70 | 4-6 | ||
![]() | 4.02 | 8-6 |
Guardians at Tigers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Guardians 54-52 | -1.5 | +1.5-205 | o7.5+100 | +110 |
Tigers 50-55 | u7.5 | -1.5+170 | u7.5-120 | -130 |

Comerica ParkDetroit
Guardians vs. Tigers Expert Picks
Brandon Kravitz
Last 30d: 45-43-0 (+5.4u)
Under 7.5 (Live)+110
1.1u
For logging purposes only, didn’t realize this had been fulfilled on the exchanges.
The Propfessor
Last 30d: 16-36-0 (-2.6u)
DET -120 (F5)
0.85u
Wags Wins
Last 30d: 183-172-4 (-5.8u)
DET -117
1.25u
💰🦡 Jake
Last 30d: 68-68-1 (+19.6u)
C.Mize o16.5 Outs-113
1u
Austin Pendergrass
Last 30d: 46-18-3 (+14.3u)
Under 7.5-122
0.41u
Frank Ammirante
Last 30d: 322-378-8 (-52.0u)
DET -120
1.2u
Under 4 (F5)-125
1u
Kyle Murray
Last 30d: 52-61-1 (+9.1u)
DET -124 (F5)
1.24u
Ryan Minion
Last 30d: 205-301-17 (-85.3u)
J.Ramirez o1.5 Hits + Runs + RBIs-123
$1.00
Adam Kaufman
Last 30d: 118-102-3 (+13.8u)
CLE +105
1.05u
Ryan Minion
Last 30d: 205-301-17 (-85.3u)
J.Ramirez o1.5 Total Bases+117
$1.00

Sean Zerillo
Last 30d: 115-141-10 (-12.0u)
DET -110
0.55u
Bet to -120
Under 7.5-114
0.5u
Bet to -122
Doug Ziefel
Last 30d: 99-99-2 (+9.9u)
Under 7.5-112
0.5u
Guardians vs. Tigers Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Guardians vs. Tigers Public Betting Percentages
Betting Trends
- Tigers are 3-2 in their last 5 games.
- Tigers are 1-4 in their last 5 games against the spread
- Tigers are 23-29 in their road games against the spread
- The totals have gone OVER in 1 of Tigers' last 5 games
- The totals have gone OVER in 19 of Tigers' 53 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. Tigers Injury Updates

Guardians Injuries

Tigers Injuries
- Reese OlsonSP
Olson is out with shoulder
Out
- Jackson JobeSP
Jobe is out with elbow
Out
- Trey SweeneySS
Sweeney is out with shoulder
Out
- Sawyer Gipson-LongSP
Gipson-Long is out with oblique
Out
- Beau BrieskeRP
Brieske is out with groin
Out
Guardians vs. Tigers Box Score
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 98 | 5.2 | 6 | 0 | |
![]() | 5 | 0.1 | 1 | 0 | |
![]() | 16 | 0.2 | 2 | 0 | |
![]() | 10 | 0.2 | 1 | 1 | |
![]() | 9 | 0.2 | 1 | 0 | |
![]() | 16 | 1 | 2 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 1-3 | 1 | 0 | 1 |
![]() | 1-4 | 0 | 0 | 1 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 1-3 | 1 | 1 | 1 |
![]() | 3-3 | 1 | 0 | 0 |
Tigers Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 95 | 6.2 | 4 | 2 | |
![]() | 27 | 0.2 | 1 | 1 | |
![]() | 25 | 1.2 | 2 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 0-4 | 0 | 0 | 0 |
![]() | 1-3 | 0 | 0 | 0 |
![]() | 1-3 | 0 | 0 | 0 |
![]() | 2-4 | 1 | 1 | 1 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-2 | 0 | 0 | 0 |
![]() | 0-1 | 0 | 0 | 0 |
![]() | 0-1 | 0 | 0 | 0 |
![]() | 1-4 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 0-2 | 0 | 0 | 0 |
![]() | 0-1 | 0 | 0 | 0 |
![]() | 0-1 | 0 | 0 | 0 |
![]() | 1-2 | 0 | 0 | 0 |
![]() | 1-2 | 0 | 0 | 0 |
![]() | 1-2 | 0 | 0 | 0 |
Guardians vs. Tigers Odds Comparison
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Guardians at Tigers Team Totals
MatchupOverUnder | ||
|---|---|---|
Guardians 54-52 | N/A | N/A |
Tigers 50-55 | N/A | N/A |

































