Mariners vs. Astros Odds & Betting Predictions - September 21, 2025

Mariners at Astros

11:10 pm • ESPN
7 - 3
Starting Pitchers
pitcherteameraw-l
Jason Alexander logoJ.AlexanderHouston Astros logo3.664-2
Logan Gilbert logoL.GilbertSeattle Mariners logo3.446-6

Mariners at Astros Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Mariners
6-6
-1.5
-1.5+110
o8.5-105
-149
Astros
0-0
u8
+1.5-137
u8.5-115
+122
location pinSunday 11:10 p.m.
September 21, 2025
Daikin ParkHouston
Mariners vs. Astros Expert Picks
Picks Office
Picks Office
Last 30d: 91-77-3 (+8.5u)
SEA -130
1.54u

Mariners vs. Astros Previews & Analysis

  • Mariners vs Astros: Expect a Tight Sunday Night Battle article feature image

    Mariners vs Astros: Expect a Tight Sunday Night Battle

    Nick Martin•
    Sep 21, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Mariners vs. Astros Public Betting Percentages

Away Logo

Mariners

Public

55%

Bets%

45%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Astros
82-8037-4445-3643-6039-18
Mariners
69-9336-4533-4844-6924-22

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Astros
72-83-736-43-236-40-545-56-225-27-5
Mariners
88-68-641-35-547-33-158-49-628-18

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Astros
87-7546-3541-4056-4731-26
Mariners
90-7251-3039-4266-4722-24

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20thSEAL 4-6+1.5 LO 8SEA -109
Sep 20thSEAL 0-4+1.5 LU 7.5SEA -111
Sep 18thTEXW 5-2+1.5 WU 7.5HOU +122
Sep 17thTEXW 6-5+1.5 WO 7.5HOU +100
Sep 16thTEXW 6-3-1.5 WO 8.5HOU -132

Mariners vs. Astros Injury Updates

Mariners Injuries

    Astros Injuries

    • Pedro Leon
      RF

      Leon is out with knee

      Out

    • Hayden Wesneski
      RP

      Wesneski is out with elbow

      Out

    Mariners vs. Astros Box Score
    Mariners Player Stats
    Projected
    PITCHERPCIPKER
    Logan Gilbert logoRL.Gilbert, P91641
    Caleb Ferguson logoLC.Ferguson, P130.101
    Carlos Vargas logoRC.Vargas, P201.211
    Matt Brash logoRM.Brash, P11110
    HITTERSH-ABRHRRBI
    Randy Arozarena logo1R.Arozarena, LF1-4100
    Cal Raleigh logo2C.Raleigh, C1-4112
    Julio Rodriguez logo3J.Rodriguez, CF1-4000
    Josh Naylor logo4J.Naylor, 1B2-4000
    Jorge Polanco logo5J.Polanco, 2B1-4100
    Leo Rivas logo5L.Rivas, 2B0-0000
    Eugenio Suarez logo6E.Suarez, 3B1-3100
    Dominic Canzone logo7D.Canzone, DH0-3100
    Mitch Garver logo7M.Garver, PH0-1000
    Mitch Garver logo7M.Garver, DH0-1000
    Victor Robles logo8V.Robles, RF0-3101
    J.P. Crawford logo9J.Crawford, SS1-4114
    Astros Player Stats
    Projected
    PITCHERPCIPKER
    Jason Alexander logoRJ.Alexander, P371.117
    Enyel De Los Santos logoRE.De Los Santos, P141.210
    AJ Blubaugh logoRA.Blubaugh, P34310
    Craig Kimbrel logoRC.Kimbrel, P20130
    Nick Hernandez logoRN.Hernandez, P18110
    Bryan King logoLB.King, P11100
    HITTERSH-ABRHRRBI
    Jose Altuve logo1J.Altuve, 2B2-3001
    Carlos Correa logo2C.Correa, 3B0-4000
    Isaac Paredes logo3I.Paredes, DH1-4111
    Jesus Sanchez logo4J.Sanchez, LF0-4000
    Christian Walker logo5C.Walker, 1B1-4000
    Yainer Diaz logo6Y.Diaz, C0-4000
    Jake Meyers logo7J.Meyers, CF0-4000
    Zach Cole logo8Z.Cole, RF2-4211
    Mauricio Dubon logo9M.Dubon, SS1-3000
    Victor Caratini logo9V.Caratini, PH0-1000

    Mariners vs. Astros Odds Comparison

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    Mariners at Astros Team Totals

    MatchupOverUnder
    Mariners
    6-6
    o4.5-110
    u4.5-117
    Astros
    0-0
    o3.5-111
    u3.5-116