Yankees vs. Red Sox Odds & Betting Predictions - April 22, 2026

Yankees at Red Sox

10:45 pm • MLB Network
@
Starting Pitchers
pitcherteameraw-l
Ranger Suarez logoR.SuarezBoston Red Sox logo3.221-1
Max Fried logoM.FriedNew York Yankees logo2.972-1

Yankees at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Yankees
14-9
-1.5
-1.5+125
o7.5-120
-135
Red Sox
9-14
u7.5
+1.5-150
u7.5-102
+115
location pinWednesday 10:45 p.m.
April 22, 2026
Fenway ParkBoston
thermometer image47°Fahrenheit
rain image16%Rain
wind image8Wind
Yankees vs. Red Sox Expert Picks
Collin Whitchurch
Collin Whitchurch
Last 30d: 87-166-6 (+2.5u)
C.Wong To Record 2+ Total Bases Yes+176
0.13u
Frank Ammirante
Frank Ammirante
Last 30d: 252-298-14 (-5.2u)
W.Contreras o0.5 HR+560
0.1u
Brian Bitler
Brian Bitler
Last 30d: 72-70-1 (+1.4u)
BOS +125
3u
Picks Office
Picks Office
Last 30d: 195-178-7 (+4.9u)
Under 8-120
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Doug Ziefel
Doug Ziefel
Last 30d: 278-369-23 (-21.3u)
R.Suarez u5.5 Ks-137
0.69u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 279-249-8 (+13.1u)
NYY -1.5+135
0.2u
#EV Pinny +127 Circa +120 BM +122 BO +125
Frank Ammirante
Frank Ammirante
Last 30d: 252-298-14 (-5.2u)
Under 8-118
1.18u
M.Fried o17.5 Outs-155
1.55u
R.Suarez o16.5 Outs-130
1.3u
Sean Zerillo
Sean Zerillo
Last 30d: 158-154-12 (-7.4u)
NYY -140
0.7u
Bet to -150
Doug Ziefel
Doug Ziefel
Last 30d: 278-369-23 (-21.3u)
BOS +125
0.4u

Yankees vs. Red Sox Previews & Analysis

  • Yankees vs Red Sox: Struggling Boston Gives This Pick Value article feature image

    Yankees vs Red Sox: Struggling Boston Gives This Pick Value

    Nick Martin
    Apr 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Yankees vs. Red Sox Public Betting Percentages

Away Logo

Yankees

Public

80%

Bets%

20%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
7-163-84-87-130-3
Yankees
12-116-76-410-112-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
12-114-78-410-102-1
Yankees
9-12-26-6-13-6-18-11-21-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
9-145-64-89-110-3
Yankees
14-98-56-412-92-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 21stNYYL 0-4+1.5 LU 8NYY -121
Apr 20thDETW 8-6-1.5 WO 8.5BOS -135
Apr 19thDETL 2-6-1.5 LO 7DET -142
Apr 18thDETL 1-4+1.5 LU 6.5DET +124
Apr 17thDETW 1-0-1.5 LU 8BOS -128

Red Sox vs. Yankees Injury Updates

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Patrick Sandoval
    SP

    Sandoval is out with elbow

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

  • Romy Gonzalez
    1B

    Gonzalez is out with shoulder

    Out

Yankees Injuries

  • Carlos Rodon
    SP

    Rodon is out with elbow

    Out

  • Gerrit Cole
    SP

    Cole is out with elbow

    Out

  • Clarke Schmidt
    SP

    Schmidt is out with elbow

    Out

  • Anthony Volpe
    SS

    Volpe is out with shoulder

    Out

Yankees vs. Red Sox Starting Lineups
Yankees Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Max Fried logoLM.Fried, P2-12.970.8106.21
HITTERSAVGOBPSLGHR
Amed Rosario logo1A.Rosario, 3B.250.302.5003
Aaron Judge logo2A.Judge, RF.235.343.5889
Ben Rice logo3B.Rice, 1B.319.461.7548
Giancarlo Stanton logo4G.Stanton, DH.253.306.4183
Cody Bellinger logo5C.Bellinger, CF.278.385.4563
Randal Grichuk logo6R.Grichuk, LF.167.192.2920
Jazz Chisholm logo7J.Chisholm, 2B.182.276.2470
Jose Caballero logo8J.Caballero, SS.234.280.3251
Austin Wells logo9A.Wells, C.185.338.2591
Red Sox Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Ranger Suarez logoLR.Suarez, P1-13.221.0756.04
HITTERSAVGOBPSLGHR
Ceddanne Rafaela logo1C.Rafaela, CF.288.373.3791
Willson Contreras logo2W.Contreras, 1B.273.398.4554
Wilyer Abreu logo3W.Abreu, RF.282.337.4593
Trevor Story logo4T.Story, SS.189.225.3052
Andruw Monasterio logo5A.Monasterio, DH.214.290.2860
Jarren Duran logo6J.Duran, LF.162.240.2501
Caleb Durbin logo7C.Durbin, 3B.155.250.2250
Connor Wong logo8C.Wong, C.333.385.5000
Isiah Kiner-Falefa logo9I.Kiner-Falefa, 2B.200.259.2000

Yankees vs. Red Sox Odds Comparison

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Yankees at Red Sox Team Totals

MatchupOverUnder
Yankees
14-9
N/A
N/A
Red Sox
9-14
N/A
N/A