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Orioles vs Red Sox Game 1 Prediction, Pick, MLB Odds for Wednesday, July 22

Orioles vs Red Sox Game 1 Prediction, Pick, MLB Odds for Wednesday, July 22 article feature image
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Bob DeChiara-Imagn Images. Pictured: Red Sox SP Jake Bennett

The Boston Red Sox host the Baltimore Orioles on July 22, 2026. First pitch from Fenway Park is scheduled for 1:35 p.m. ET. The game will be broadcast on NESN.

The Red Sox are favored by -149 on the moneyline and by -1.5 on the run line. The Orioles are +123 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.

Find my MLB picks and Orioles vs Red Sox prediction below, as well as probable pitchers, weather report, and more.


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Orioles vs Red Sox Prediction

  • Orioles vs Red Sox Pick: Jake Bennett Under 16.5 Outs (+100)

My Orioles vs Red Sox best bet is on Jake Bennett to record 16 outs or fewer. Make sure to find the best odds by checking our live MLB odds page.


Orioles vs Red Sox Odds

Orioles Logo
Wednesday, Jul 22
1:35 p.m. ET
NESN
Red Sox Logo
Orioles Odds
SpreadTotalMoneyline
+1.5
-172
9.5
102o / -123u
+123
Red Sox Odds
SpreadTotalMoneyline
-1.5
+142
9.5
102o / -123u
-149
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Orioles vs Red Sox moneyline: Orioles +123, Red Sox -149
  • Orioles vs Red Sox over/under: 9.5 (+102o / -123u)
  • Orioles vs Red Sox spread: Orioles +1.5 (-172), Red Sox -1.5 (+142)

Orioles vs Red Sox Probable Pitchers

Dean Kremer (RHP, BAL)StatJake Bennett (LHP, BOS)
1-2W-L5-3
-0.2fWAR (FanGraphs)1.5
4.15 / 4.91ERA / xERA2.35 / 2.99
6.18 / 3.46FIP / xFIP3.03 / 3.83
21.4K-BB%14.3
34.8GB%48.3
.224BABIP.232
90Stuff+92
99Location+115

Orioles vs Red Sox MLB Betting Preview, Prediction

By Derek Carty

THE BAT X is forecasting 14.40 pitching outs for Red Sox starter Jake Bennett compared to 16.41 pitching outs implied by the oddsmakers, so I believe there is value here.

If you take the under, you'd be projected to win 69% of the time, resulting in a 39% ROI. Based on a $100 wager, the expected value here would be $38.72. This play is good down to at least -171.

Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!

Pick: Jake Bennett Under 16.5 Outs (+100, DraftKings)


Orioles vs Red Sox Weather


Get the latest coverage on MLB Weather.
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