MLB Picks, Best Bets, Props, Predictions Today – April 22

MLB Picks, Best Bets, Props, Predictions Today – April 22 article feature image
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Photo Credit: Benny Sieu-Imagn Images. Pictured: Brent Rooker (25) and Lawrence Butler (4)

The baseball schedule makers have treated us to a full, 15-game slate on Tuesday, April 22.

There are plenty of MLB picks and props to sift through, but our MLB betting experts have already done the bulk of the heavy lifting.

After sorting through the odds, they've identified the best betting value on the board. So, continue reading as tonight's MLB best bets are below.

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MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Los Angeles Dodgers LogoChicago Cubs Logo
7:40 p.m.
Los Angeles Dodgers LogoChicago Cubs Logo
7:40 p.m.
Toronto Blue Jays LogoHouston Astros Logo
8:10 p.m.
Texas Rangers LogoOakland Athletics Logo
10:05 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.
Dodgers vs Cubs Prediction, Pick, Odds for Tuesday, April 22 Image

Allan Lem's Dodgers vs Cubs Best Bet: Back Imanaga

Los Angeles Dodgers Logo
Tuesday, April 22
7:40 p.m. ET
MLB.TV
Chicago Cubs Logo
Shota Imanaga Under 3.5 Earned Runs Allowed (-130)
DraftKings  Logo

By Allan Lem

It's a tough matchup against the Dodgers, but I'll back Shota Imanaga tonight.

He owns a career 2.81 ERA through 34 starts and has had some success against the Dodgers in the past (current roster is 9-for-51 against him with 3 HRs, 3 RBI and a .176 batting average). He also held them to four scoreless innings earlier this season.

It's also a small sample, but the Dodgers have been below average this season against lefties, posting a 81 wRC+. With the Dodgers implied for 4.5 total runs, I'll side with Imanaga to stay under 3.5 earned runs.

Pick: Shota Imanaga Under 3.5 Earned Runs Allowed (-130)



Grant Neiffer's Dodgers vs Cubs Best Bet: Can Tucker Go Deep?

Los Angeles Dodgers Logo
Tuesday, April 22
7:40 p.m. ET
MLB.TV
Chicago Cubs Logo
Kyle Tucker Over 0.5 Home Runs (+450)
BetMGM Logo

By Grant Neiffer

Kyle Tucker is a great play today, even in a slightly below average matchup.

Dustin May is good at suppressing power, but is more susceptible to lefty power as his fly ball rate is a bit higher. The ballpark also isn't bad for power and the wind is blowout out slightly.

Tucker has been one of the best hitters in the league thus far this season with six homers to go along with career highs in hard-hit rate and barrels. He's playing some of the best baseball of his career and his line today should be about 70 points lower.

Pick: Kyle Tucker Over 0.5 Home Runs (+450)



Charlie Wright's Blue Jays vs Astros Best Bet: Back Bassitt

Toronto Blue Jays Logo
Tuesday, April 22
8:10 p.m. ET
MLB.TV
Houston Astros Logo
Chris Bassitt Under 2.5 Earned Runs Allowed (-140)
DraftKings  Logo

By Charlie Wright

Chris Bassitt is off to a tremendous start, allowing just two earned runs across four starts.

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