HomeRight ArrowMLB

MLB Picks, Predictions Today: Best Bets for Padres vs Rockies, More for Wednesday April 22

MLB Picks, Predictions Today: Best Bets for Padres vs Rockies, More for Wednesday April 22 article feature image
4 min read
Credit:

Apr 21, 2026; Denver, Colorado, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) during the seventh inning against the Colorado Rockies at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images

There are very few things in this world than gambling on daytime baseball.

Below are three expert MLB picks and predictions for Today's slate of games.

MLB Picks, Predictions Today

The team logos in the table below represent the matchups our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
St. Louis Cardinals LogoMiami Marlins Logo
12:10 PM
Oakland Athletics LogoSeattle Mariners Logo
4:10 PM
San Diego Padres LogoColorado Rockies Logo
8:40 PM
Action Logo
All Day
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.
Playbook


Cardinals vs Marlins Moneyline Picks Today

St. Louis Cardinals Logo
Wednesday, April 22
12:10 PM ET
MLB.TV
Miami Marlins Logo
Marlins ML
FanDuel Logo

By Sean Paul

I’m rolling with the Fish.

I don’t like Kyle Leahy as a starter, and Janson Junk is due for plenty of positive regression.

Throw in Miami’s bullpen advantage and Stowers’ return, and I’m liking Miami’s chances on Wednesday.

Check out Paul's full Marlins-Cardinals preview here:

Paul's Preview for Cardinals vs Marlins Image

Pick: Marlins ML (-140 or Better)



A's vs Mariners Moneyline Pick Today

Oakland Athletics Logo
Wednesday, April 22
4:10 PM ET
MLB.TV
Seattle Mariners Logo
A's ML
FanDuel Logo

By Tanner McGrath

This game triggered one of our Action PRO betting systems, powered by Evan Abrams.

MLB Icon
Evan Abrams – Low Support Division Dog
the number of bets compared to the day's average is between 1.01 and 3.94
the moneyline change from open to close is between -200 and 0
the moneyline % is between 8% and 29%
the game is played during the Regular season
the game is a Division game
the team is the Dog
$15,397
WON
962-1218-0
RECORD
44%
WIN%

This system targets divisional underdogs in MLB regular-season games that receive low public support but show signs of sharp action or value.

These dogs have moneyline support from less than 30% of bettors, yet still experience little or no negative line movement, suggesting the smart money is holding the line.

Additionally, these bets occur in division games, where familiarity and tighter matchups often reduce the gap between underdog and favorite.

The bet count is modestly above average, further hinting at targeted action rather than mass public overreaction.

I’ve been all over the A’s in this series against the Mariners.

While the Mariners have a massive starting pitching and bullpen advantage — as they will again in this game — my numbers project the Athletics as the better offensive, defensive, and base-running team.

As a result, I project the A’s closer to +130 on the ML.

Read McGrath's full A's-Mariners preview here:

Pick: A's ML (+150 or Better)



Padres vs Rockies Home Run Pick Today

San Diego Padres Logo
Wednesday, April 22
8:40 PM ET
MLB.TV
Colorado Rockies Logo
Fernando Tatis Home Run (+379 or Better)
FanDuel Logo

By Derek Carty

THE BAT X is forecasting 0.27 home runs for Fernando Tatis Jr.

Oddsmakers are implying 0.21 home runs, so I believe there is value.

If you take the over, you'd be projected to win 23% of the time, resulting in a 26% ROI with an expected value of $26.34 (based on a $100 wager).

This play is good down to at least +379.

Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics!

Pick: Fernando Tatis Home Run (+379 or Better)



Sean Zerillo's Full Action App Card Today

Need more picks for Wednesday's action on the diamond? It's always wise to see what our guy Zerillo is betting on!

If you haven't already, make sure you download the Action Network app and sign up for an Action PRO subscription:

Phone With the Action App Open
The must-have app for MLB bettors
The best MLB betting scoreboard
Free picks from proven pros
Live win probabilities for your bets
Action PRO Upsell Image
Premium picks, tools & analysis
Track & follow smart money
Biggest player prop edges
Real-time expert pick alerts


Author Profile
About the Author

Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.