We're on to the second day of the MLB season and our baseball betting experts are all over it with five MLB predictions and best bets for the nine-game slate, featuring Orioles vs Blue Jays, Red Sox vs Rangers and Tigers vs Dodgers.
Among their MLB picks for Friday are props for Vladimir Guerrero Jr. and Wilyer Abreu, in addition to over/under, moneyline and spread bets.
Find our five MLB best bets and predictions for Friday, March 28, below.
MLB Predictions, Best Bets, Props for Friday, March 28
| Game | Time (ET) | Pick |
|---|---|---|
  | 10:10 p.m. | |
  | 4:10 p.m. | |
  | 7:07 p.m. | |
| 7:07 p.m. | |
  | 8:05 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Bruce Marshall's Rockies vs Rays Best Bet: Target the Over
By Bruce Marshall
Here's a new adventure in Tampa Bay: the Rays will be playing at the Yankees' spring training and minor-league facility, Steinbrenner (nee Legends) Field, this season, in Tampa right across from the Bucs' Raymond James Stadium.
When considering a proper venue for the new baseball park in the area, we can only hope that the Rays figure out they have to be on the Tampa, and not St. Pete side of the bay.
We'll see how it goes in this temporary venue, but for the opener, we suggest the Rockies hold onto their hats, as starter Kyle Freeland was battered mercilessly last March and April, allowing 25 runs (23 earned) and 32 hits across just 15 2/3 IP (that equated to a 13.21 ERA). When the dust settled in October, Freeland had a 5.98 ERA on the road.
Ryan Pepiot looks a better bet on the Rays' side, but he's not lasting beyond five innings at the most, and it will be up to Kevin Cash's bullpen to try and keep this score below eight runs.
Pick: Over 8 (-105)
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Bruce Marshall's Orioles vs Blue Jays Best Bet: Another O's Win?
By Bruce Marshall
We like the thought of the Orioles as an underdog after their bats looked to be midseason form on Opening Day.
That 12-2 romp past the Blue Jays was comprehensive, as the Birds bashed six homers, including two each by Adley Rutschman and Cedric Mullins, while piling up 14 hits in the rout as there was nowhere for the Toronto pitchers to hide.
After starter Jose Berrios was touched for six runs in five innings, the bullpen allowed another six over the remainder of the game.
Charlie Morton makes his Baltimore debut, likely to get some run support, before he's out of there after five innings max.
O's manager Brandon Hyde, however, has a bit more confidence in his relievers, who kept Toronto off of the board in the final three innings on Thursday.
Pick: Orioles Moneyline (+110)
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Kyle Murray's Orioles vs Blue Jays Best Bet: Vlad Jr. Total Bases
By Kyle Murray
I love this spot here for Vlad Jr. for kind of a niche reason, but hear me out.
Vlad Jr. is one of the best pure hitters in baseball; he is very patient and does a great job and putting the ball in play. Opening Day was a perfect example as he drew two walks.
However, walks don't help us here.
This is a great matchup because Charlie Morton only walked 5% of right-handed hitters in 2024. He also allowed a .213 ISO and a .338 wOBA to that side of the plate; Vlad Jr. hit RHPs to a tune of .218 ISO and a .402 wOBA.
Pick: Vladimir Guerrero Jr. Over 1.5 Total Bases (+100)
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Kyle Murray's Red Sox vs Rangers Best Bet: Wilyer Abreu Hitter Combo
By Kyle Murray
