Twins vs Nationals Prediction, Pick, Odds: MLB Weather-Oriented Over

The Washington Nationals host the Minnesota Twins on May 5, 2026. First pitch from Nationals Park is scheduled for 6:45 p.m. EDT. The game will be broadcast on NATS.

The Twins are favored by -112 on the moneyline and by -1.5 on the run line. The Nationals are -106 on the moneyline and +1.5 on the run line. The total is set at 9 runs.

Find my MLB picks and Twins vs Nationals prediction below, as well as probable pitchers, weather report, and more.

Twins vs Nationals Prediction

• Twins vs Nationals Pick: Over 9 (-104, FanDuel)

My Twins vs Nationals best bet is over 9 total runs. Make sure to find the best odds by checking our live MLB odds page.

May 5, 2026

6:45 p.m. EDT

NATS

Twins Odds
Spread	Total	Moneyline
-1.5 -166	9 -115o / -105u	-112

Nationals Odds
Spread	Total	Moneyline
+1.5 +145	9 -115o / -105u	-106

Odds via FanDuel. Get up-to-the-minute MLB odds here.

• Twins vs Nationals moneyline: Twins -112, Nationals -106
• Twins vs Nationals over/under: 9 (-115o / -105u)
• Twins vs Nationals spread: Twins -1.5 (+145), Nationals +1.5 (-166)

Twins vs Nationals MLB Betting Preview

The biggest takeaway here is that it’s the warmest outdoor game on the slate today. The temperature is going to be near 79 degrees, and we also have the wind blowing out pretty aggressively to left field in D.C.

This is one of the more underrated wind-receptive parks in the majors. Wind blowing out versus wind blowing in makes a pretty big difference, and today the wind will be blowing out, and it’s also going to be warm.

Twins vs Nationals Pick, Betting Analysis

So, from a temperature standpoint, this is a weather-oriented over for me — Twins and Nationals over 9 up to -105.

Pick: Over 9 (-104, FanDuel)

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