The Minnesota Twins host the Chicago White Sox on June 1, 2026. First pitch from Target Field is scheduled for 7:40 p.m. EDT. The game will be broadcast on CHSN.
The Twins are favored by -161 on the moneyline and by -1.5 on the run line. The White Sox are +135 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and White Sox vs Twins prediction below, as well as probable pitchers, weather report, and more.
White Sox vs Twins Prediction
- White Sox vs Twins Pick: Twins Moneyline
My White Sox vs Twins best bet is on the Minnesota Moneyline. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Twins Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +125 | 8 -103o / -114u | +135 |
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -155 | 8 -103o / -114u | -161 |
- White Sox vs Twins moneyline: White Sox +135, Twins -161
- White Sox vs Twins over/under: 8 (-103o / -114u)
- White Sox vs Twins spread: Twins -1.5 (+125 ), White Sox +1.5 (-155)
White Sox vs Twins Probable Pitchers
| RHP David Sandlin (CHW) | Stat | RHP Joe Ryan (MIN) |
|---|---|---|
| 1-0 | W-L | 3-3 |
| 0.1 | fWAR (FanGraphs) | 2.1 |
| 1.50/1.38 | ERA / xERA | 2.94/2.83 |
| 3.91/4.10 | FIP / xFIP | 2.59/3.46 |
| 21.1% | K-BB% | 22.0% |
| 26.7% | GB% | 38.8% |
| .000 | BABIP | .259 |
| 104 | Stuff+ | 108 |
| 103 | Location+ | 106 |
White Sox vs Twins MLB Betting Preview, Pick
Joe Ryan is cruising. Six straight outings allowing fewer than three earned runs. And tonight, he gets a matchup with the Murakami-less White Sox. Even with Murakami hitting 20 homers in two months, this lineup had an OPS short of elite because of their high strikeout rates and low batting averages.
Removing Murakami makes a big difference. Taking him out of the stat calculation for the year drops their team's OPS from .723 to .700. That would take them from the sixth-best OPS to 15th. So they're a league-average offense at best right now, and I'd take the UNDER on that.
I think Joe Ryan is ready to cook. Both his fastball and curveball have been so sick this year. He has a 2.68 SIERA, the way I calculate it. A 22% K-BB% and just four homers allowed. I'm not sure what he's done to allow these few homers, but it's something. It's the best home run rate of his career by a mile. I think it'll come up, but 2+ months in, I'm starting to believe some kind of tweak was made, and it's worked.
On the other side is an interesting arm in David Sandlin. He came up from the minors for the White Sox and threw six innings of one-hit, one-run ball against the Twins last week. Now he'll see them again. Which could work to the Twins' advantage. The memory of how this guy operates is fresh in their minds.
Sandlin did have a 35% K% in the minors this year. But the stuff models didn't love his stuff from that first outing, and this guy wasn't exactly on our radar before getting pushed into this rotation. So I wouldn't want to bet positively on him. There aren't lines out for him at this point, and that tells you the books are reeling a bit on him.
But if we're getting under 4.5 strikeouts for around even money, I'd be on that. The projection on him is 3.8 strikeouts tonight in my model.
But I love the Twins behind Joe Ryan. I looked at the outs recorded market for Ryan, and DraftKings likes him a lot, too! Too much, in fact. He's at over 17.5 outs for -168. That means seven innings, which he's done twice all year. No thanks on that!
Pick: Twins Moneyline
