West Virginia vs. Clemson Odds & Betting Predictions - November 21, 2025

West Virginia at Clemson

11:30 pm • ESPNU

West Virginia Mountaineers

16-9

67 - 70

Clemson Tigers

20-6

MatchupOpenSpreadTotalMoneyline
West Virginia 16-9	+3.5-112	o132.5-112	+143
Clemson 20-6	u133.5	-3.5-108	u132.5-105	-171

Friday 11:30 p.m.

November 21, 2025

TD ArenaCharleston

WVU +3.5-110

1.14u

WVU u64.5-114

1.71u

CLEM -3.5-105

0.53u

West Virginia vs Clemson: Total Pick for Friday Night
John Feltman•
Nov 21, 2025 UTC

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NCAAB Public Betting

Clemson are 3-2 in their last 5 games.
Clemson are 3-2 in their last 5 games against the spread
Clemson are 9-2 in their road games against the spread
The totals have gone OVER in 1 of Clemson' last 5 games
The totals have gone OVER in 5 of Clemson' 15 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Clemson	16-10	7-8	9-2	13-10	3-0
West Virginia	13-12	8-8	5-4	6-7	6-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Clemson	10-16	5-10	5-6	9-14	1-2
West Virginia	8-17	4-12	4-5	3-10	4-6

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Clemson	20-6	N/A	N/A	20-3	0-3
West Virginia	16-9	N/A	N/A	10-3	4-6

date	opponent	score	spread	over/under	moneyline
Nov 18th	UNA	W 81-61	-25.5 L	U 144.5	CLEM -9000
Nov 15th	@GTWN	L 74-79	-1.5 L	O 142.5	GTWN -117
Nov 12th	MORE	W 83-56	-29.5 L	U 151.5	CLEM -6500
Nov 8th	WEBB	W 97-59	-	-	-
Nov 4th	UNH	W 88-38	-29.5 W	U 146.5	CLEM -20000

Zac Foster
G
Foster is out for season with knee
Out for Season

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West Virginia

Clemson

23-57 (40%)

Field Goals

24-52 (46%)

12-19 (63%)

Free Throws

15-19 (79%)

9-23 (39%)

7-22 (32%)

Rebounds

Assists

Turnovers

Steals

Blocks

Fouls

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MatchupOverUnder
West Virginia 16-9	N/A	N/A
Clemson 20-6	N/A	N/A

West Virginia vs. Clemson Odds & Betting Predictions - November 21, 2025

West Virginia at Clemson

West Virginia Mountaineers

Clemson Tigers

West Virginia at Clemson Odds

Spread, Total, Moneyline

West Virginia vs. Clemson Previews & Analysis

West Virginia vs Clemson: Total Pick for Friday Night

Prop Odds Comparison

Line Movement Tracker

West Virginia vs. Clemson Public Betting Percentages

West Virginia

Public

Clemson

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

West Virginia vs. Clemson Injury Updates

West Virginia Injuries

Clemson Injuries

West Virginia vs. Clemson Odds Comparison

West Virginia at Clemson Team Totals