The Detroit Mercy Titans take on the Michigan State Spartans in East Lansing, MI. Tip-off is set for 6:30 p.m. ET on BTN.
Michigan State is favored by -31.5 points on the spread, and the total is set at 148.5 points.
Here’s my Detroit vs. Michigan State predictions and college basketball picks for November 21, 2025.
Detroit vs Michigan State Prediction
My Pick: Under 148.5
My Detroit vs Michigan State best bet is on the under. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Detroit vs. Michigan State Odds
| Detroit Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+31.5 -115 | 148.5 -115 / -105 | OFF |
| Michigan State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-31.5 -105 | 148.5 -115 / -105 | OFF |
- Detroit vs Michigan State spread: Michigan State -31.5
- Detroit vs Michigan State over/under: 148.5 points
Detroit vs Michigan State College Basketball Betting Preview
Detroit has one victory this season, and it came against a non-Division I team in Cleary.
Meanwhile, Michigan State is coming off a drubbing of No. 12 Kentucky at the Champions Classic and is 4-0 on the season, with another victory coming against then-No. 14 Arkansas.
But for this particular game, the angle doesn't come on the spread — especially with Michigan State potentially being in a letdown spot.
Instead, our very own Evan Abrams has a system — "Stadium Unders" — that's targeting the under in this buy game.
In college basketball, games played in specific arenas often trend under due to consistent environmental and stylistic factors tied to the venue rather than neutral-court unfamiliarity. In the case of this game, that's the Breslin Center.
Many of these stadiums, both home and neutral, feature deeper backdrops, unique lighting and court setups that slow pace and limit shooting efficiency.
Teams playing in these environments, especially those coming off an under in their previous outing (which Michigan State and Detroit are), tend to continue that pattern as coaches emphasize defense and control over tempo.
Across multiple seasons, these venues have shown a reliable tendency for lower scoring outcomes, making the under a favorable position in stadiums where shooting rhythm and offensive flow are historically harder to sustain.
On top of that, this system has 27% return on investment (ROI) this season and a 27% all-time ROI, making this a reliable play.
My Pick: Under 148.5
