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Michigan St vs. USC Odds & Betting Predictions - September 21, 2025

Michigan St at USC

3:00 am • FOX

Michigan State Spartans

3-2
31
31 - 45

USC Trojans

4-1
45

Michigan St at USC Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Michigan St
3-2
+14.5
+18.5-114
o55.5-110
+625
USC
4-1
u56.5
-18.5-106
u55.5-110
-950
location pinSunday 3:00 a.m.
September 21, 2025
Los Angeles Memorial ColiseumLos Angeles
Michigan St vs. USC Expert Picks
YBK Picks.com
Last 30d: 51-40-3 (+16.1u)
USC -19.5-105
3u
Will Brinson
Will Brinson
Last 30d: 42-35-1 (+3.8u)
USC -18.5-110
1.1u
Picks Office
Picks Office
Last 30d: 65-75-2 (-6.2u)
USC -18-110
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 100-133-4 (+19.4u)
MSU +10.5 (1H)+100
1u
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 73-71-2 (+2.3u)
USC o36.5 Team Total-120
0.83u
@_Collin1 https://myaction.app/V2FMmqguNWb
USC -10 (1H)-110
0.91u
@Stuckey2 https://myaction.app/V2FMmqguNWb
Collin Wilson
Collin Wilson
Last 30d: 101-72-4 (+14.0u)
USC o37.5 Team Total-114
1u
Massive EPA edge to USC offense, also top 10 Quality and Finishing Drives.
Boomer Betz
Boomer Betz
Last 30d: 134-118-2 (+21.2u)
MSU +17.5-102
0.98u

Michigan St vs. USC Previews & Analysis

  • Michigan State vs. USC: Target Saturday's Total article feature image

    Michigan State vs. USC: Target Saturday's Total

    Mike McNamara•
    Sep 20, 2025 UTC
  • Your Week 4 NCAAF Betting Cheat Sheet article feature image

    Your Week 4 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 20, 2025 UTC
  • College Football Week 4 Best Bets & Player Props! | Big Bets On Campus LIVE! article feature image

    College Football Week 4 Best Bets & Player Props! | Big Bets On Campus LIVE!

    •
    Sep 19, 2025 UTC
  • Auburn vs Oklahoma BEST BETS! | College Football Best Bets & Preview | BBOC article feature image

    Auburn vs Oklahoma BEST BETS! | College Football Best Bets & Preview | BBOC

    Stuckey•
    Sep 19, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Michigan St vs. USC Public Betting Percentages

Away Logo

Michigan St

Public

Home Logo

USC

96%

Bets%

4%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • USC are 4-1 in their last 5 games.
  • USC are 2-3 in their last 5 games against the spread
  • USC are 0-2 in their road games against the spread
  • The totals have gone OVER in 4 of USC' last 5 games
  • The totals have gone OVER in 3 of USC' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
USC		2-32-10-22-3N/A
Michigan St		2-30-32-00-32-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
USC		4-13-01-14-1N/A
Michigan St		4-12-12-02-12-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
USC		4-1N/AN/A4-1N/A
Michigan St		3-2N/AN/A3-00-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@PURW 33-17-20.5 LU 59.5USC -1600
Sep 6thGASOW 59-20-29 WO 62.5USC -7000
Aug 30thMOSTW 73-13-36.5 WO 60USC -9000
Dec 28thTA&MW 35-31---
Nov 30thNDL 35-49+7 LO 52.5ND +207
Team Stats

Total

337
Total Yards
523
55
Total Plays
66
6.127272727272727
Yards Per Play
7.924242424242424

Passing

225
YDS
234
13/23
Comps/Atts
20/26
9.782608695652174
YPA
9
3/0
TDs/INTs
3/0
2/7
Sacks/Yards
0/0

Rushing

112
Rush Yards
289
32
Attempts
40
3.5
YPC
7.225
1
TDs
3

Turnovers

0
Fumbles Lost
1
0
Interceptions
0

Efficiency

2/3 66.67%
Redzone
6/6 100%
5/11 0%
3rd Down
8/12 0%
0/1 0%
4th Down
1/2 0%

First Downs

19
Total
27
7
Pass
11
8
Rush
13
4
Penalty
3

Misc

6/54
Penalties/Yards
9/78

Michigan St vs. USC Odds Comparison

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Michigan St at USC Team Totals

MatchupOverUnder
Michigan St
3-2
o18.5-113
u18.5-112
USC
4-1
o37.5-116
u37.5-114