Michigan St vs. USC Odds & Betting Predictions - September 21, 2025
Michigan St at USC
3:00 am • FOXMichigan St at USC Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Michigan St 3-5 | +14.5 | +18.5-114 | o55.5-110 | +625 |
USC 5-2 | u56.5 | -18.5-106 | u55.5-110 | -950 |

Los Angeles Memorial ColiseumLos Angeles
Michigan St vs. USC Expert Picks
YBK Picks.com
Last 30d: 68-35-3 (+60.9u)
USC -19.5-105
3u
Will Brinson
Last 30d: 17-20-1 (-3.3u)
USC -18.5-110
1.1u
Picks Office
Last 30d: 112-92-3 (+13.3u)
USC -18-110
1u
💰🦡 Jake
Last 30d: 116-131-6 (+2.1u)
MSU +10.5 (1H)+100
1u
Big Bets On Campus (CFB)
Last 30d: 48-57-3 (-11.3u)
USC o36.5 Team Total-120
0.83u
@_Collin1 https://myaction.app/V2FMmqguNWb
USC -10 (1H)-110
0.91u
@Stuckey2 https://myaction.app/V2FMmqguNWb
Collin Wilson
Last 30d: 100-79-1 (+12.6u)
USC o37.5 Team Total-114
1u
Massive EPA edge to USC offense, also top 10 Quality and Finishing Drives.
Boomer Betz
Last 30d: 176-161-3 (+18.2u)
MSU +17.5-102
0.98u
Michigan St vs. USC Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Michigan St vs. USC Public Betting Percentages
Betting Trends
- USC are 4-1 in their last 5 games.
- USC are 3-2 in their last 5 games against the spread
- USC are 1-2 in their road games against the spread
- The totals have gone OVER in 3 of USC' last 5 games
- The totals have gone OVER in 3 of USC' 4 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-3 | 3-1 | 1-2 | 3-3 | 1-0 | |
| 4-4 | 1-4 | 3-0 | 0-4 | 4-0 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 4-3 | 3-1 | 1-2 | 4-2 | 0-1 | |
| 6-2 | 3-2 | 3-0 | 2-2 | 4-0 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 5-2 | N/A | N/A | 5-1 | 0-1 | |
| 3-5 | N/A | N/A | 3-1 | 0-4 |
Last 5 Matchups
Team Stats
225
YDS
234
13/23
Comps/Atts
20/26
9.782608695652174
YPA
9
3/0
TDs/INTs
3/0
2/7
Sacks/Yards
0/0
6/54
Penalties/Yards
9/78
Michigan St vs. USC Odds Comparison
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Michigan St at USC Team Totals
MatchupOverUnder | ||
|---|---|---|
Michigan St 3-5 | o18.5-113 | u18.5-112 |
USC 5-2 | o37.5-116 | u37.5-114 |






