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Louisville Cardinals Odds

Next Louisville Game

Game Details
@ SMU Mustangs
SMU
location pin
Sat 11/225:00 PM

SMU vs Louisville Odds

More Odds
SpreadTotalMoneyline
LOU
+3.5-115
o52.5-111
+132
SMU
-3.5-105
u52.5-110
-158

Cardinals Injuries

All NCAAF Injuries

There are no injuries for this team currently.

Picks
Collin Wilson
Collin Wilson
Last 30d: 91-72-0 (+13.2u)
Project SMU -3.5; great situational spot, Louisville on back to back losses and off Clemson w Kentucky rivalry on deck. SMU off a bye week
187

Cardinals 2025 Schedule & Betting Odds

dateopponentscorespreadover/undermoneyline
Nov 29thUK----
Nov 22nd@SMU----
Nov 15thCLEML 19-20-1.5 LU 51CLEM -125
Nov 9thCALL 26-29-18.5 LO 48.5CAL -1100
Nov 1st@VTW 28-16-10.5 WU 52.5LOU -395
Oct 25thBCW 38-24-25.5 LO 54.5LOU -2800
Oct 17th@MIAW 24-21+10.5 WU 49.5LOU +340
Oct 4thUVAL 27-30-6.5 LU 60UVA -245
Sep 27th@PITTW 34-27-6.5 WO 53.5LOU -155
Sep 20thBGSUW 40-17-26.5 LO 50.5LOU -4000
News
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    Ohio vs. Louisville: Why Value Lies on Bobcats

    Doug Ziefel•
    Nov 15, 2025 UTC
  • Clemson vs. Louisville: Win on the Ground article feature image

    Clemson vs. Louisville: Win on the Ground

    Greg Liodice•
    Nov 14, 2025 UTC
  • Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel article feature image

    Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel

    Dead President Picks•
    Nov 11, 2025 UTC
  • Our Staff's Best Bets for Louisville vs Kentucky article feature image

    Our Staff's Best Bets for Louisville vs Kentucky

    Action Network Staff•
    Nov 11, 2025 UTC

Louisville Cardinals Football

The Louisville Cardinals are headed by Coach Jeff Brohm, leading the team to a successful season after just 2 years with the team. The Cardinals finished with a 9-4 record, with a 35-35 win in the Sun Bowl. 

The team will play Eastern Kentucky Colonels on August 30th at the L&N Stadium before taking on the James Madison Dukes.

Louisville Cardinals Point Spreads

Here’s an example of a past Cards game vs. Pittsburgh point spread.

  • Louisville +3 (-110)
  • Pittsburgh -3 (-110)

The Cardinals lost the game, 23-20, making the bet a tie or a push. This means bettors on either side got their money back. For Cardinals bets to have won, they would’ve needed to win the game or lose by one or two points. Pittsburgh backers would have needed a win by four or more for their bets to cash.

Louisville Cardinals Over/Unders

Another popular bet that can be made on college football games is an over/under or total bet. With these bets, neither the winner of the game nor the winning margin matters. Instead, you’re betting on the combined scoring of the teams.

Using their game against Georgia Tech as an example, books set the total at 54. The game finished 39-34 for Tech for a combined 73 points. This was a winner for anyone who bet the over. Had the teams combined for fewer than 63 points, under bets would have cashed; if it landed at exactly 63, both sides would've gotten their stake back.

Louisville Cardinals Moneylines

Another common college football bet is a moneyline bet. Instead of handicapping a team by a certain number of points, oddsmakers adjust the payout based on the chances either team has of winning.

Moneyline bets are easiest to understand if you think in units of $100. Were the Cardinals to defeat Georgia Tech as +150 underdogs, a $100 bet would profit $150. Had they been -150 favorites instead, you’d need to bet $150 to have a chance at a $100 return.

Louisville Cardinals Props

If you have a favorite Cardinal and want to bet on his stats for the game, look at proposition, or prop, bets. Like over/unders, prop bets are bets on whether more or less of something will happen than the books are expecting.

College football player props are far less common than NFL ones, so make sure to find a sportsbook that offers them.

Louisville Cardinals Futures

You can also bet on a variety of end-of-season results for the Cardinals. These are called futures bets.

Some Cardinals futures bets available include, among others, their odds to win the ACC, win the national title, or go over a certain number of wins for the season. These bets are priced like moneylines to reflect how likely they are to happen.

Next Louisville Game

Game Details
@ SMU Mustangs
SMU
location pin
Sat 11/225:00 PM

SMU vs Louisville Odds

More Odds
SpreadTotalMoneyline
LOU
+3.5-115
o52.5-111
+132
SMU
-3.5-105
u52.5-110
-158

Cardinals Injuries

All NCAAF Injuries

There are no injuries for this team currently.

Louisville Cardinals Football

The Louisville Cardinals are headed by Coach Jeff Brohm, leading the team to a successful season after just 2 years with the team. The Cardinals finished with a 9-4 record, with a 35-35 win in the Sun Bowl. 

The team will play Eastern Kentucky Colonels on August 30th at the L&N Stadium before taking on the James Madison Dukes.

Louisville Cardinals Point Spreads

Here’s an example of a past Cards game vs. Pittsburgh point spread.

  • Louisville +3 (-110)
  • Pittsburgh -3 (-110)

The Cardinals lost the game, 23-20, making the bet a tie or a push. This means bettors on either side got their money back. For Cardinals bets to have won, they would’ve needed to win the game or lose by one or two points. Pittsburgh backers would have needed a win by four or more for their bets to cash.

Louisville Cardinals Over/Unders

Another popular bet that can be made on college football games is an over/under or total bet. With these bets, neither the winner of the game nor the winning margin matters. Instead, you’re betting on the combined scoring of the teams.

Using their game against Georgia Tech as an example, books set the total at 54. The game finished 39-34 for Tech for a combined 73 points. This was a winner for anyone who bet the over. Had the teams combined for fewer than 63 points, under bets would have cashed; if it landed at exactly 63, both sides would've gotten their stake back.

Louisville Cardinals Moneylines

Another common college football bet is a moneyline bet. Instead of handicapping a team by a certain number of points, oddsmakers adjust the payout based on the chances either team has of winning.

Moneyline bets are easiest to understand if you think in units of $100. Were the Cardinals to defeat Georgia Tech as +150 underdogs, a $100 bet would profit $150. Had they been -150 favorites instead, you’d need to bet $150 to have a chance at a $100 return.

Louisville Cardinals Props

If you have a favorite Cardinal and want to bet on his stats for the game, look at proposition, or prop, bets. Like over/unders, prop bets are bets on whether more or less of something will happen than the books are expecting.

College football player props are far less common than NFL ones, so make sure to find a sportsbook that offers them.

Louisville Cardinals Futures

You can also bet on a variety of end-of-season results for the Cardinals. These are called futures bets.

Some Cardinals futures bets available include, among others, their odds to win the ACC, win the national title, or go over a certain number of wins for the season. These bets are priced like moneylines to reflect how likely they are to happen.