Broncos vs. 49ers Odds & Betting Predictions - August 10, 2025
Broncos at 49ers
12:30 am • NFL+Broncos at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Broncos 1-2 | +1.5 | -6.5-109 | o38.5-109 | -280 |
![]() 49ers 3-0 | u34.5 | +6.5-111 | u38.5-110 | +240 |

Levi's StadiumSanta Clara
Broncos vs. 49ers Previews & Analysis
Broncos vs. 49ers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Broncos vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 3-0 in their last 5 games.
- 49ers are 2-1 in their last 5 games against the spread
- 49ers are 2-0 in their road games against the spread
- The totals have gone OVER in 1 of 49ers' last 3 games
- The totals have gone OVER in 0 of 49ers' 1 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Broncos Injury Updates

49ers Injuries
- George KittleTE
Kittle is out with hamstring
Out
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jauan JenningsWR
Jennings is questionable with ankle
Questionable
- Brock PurdyQB
Purdy is questionable with toe
Questionable
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan WatkinsWR
Watkins is doubtful with ankle
Doubtful
- Jordan JamesRB
James is doubtful with finger
Doubtful

Broncos Injuries
- Evan EngramTE
Engram is questionable with back
Questionable
- Dre GreenlawLB
Greenlaw is out with quad
Out
- Malcolm RoachDT
Roach is out with calf
Out
Team Stats
Broncos vs. 49ers Odds Comparison
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Broncos at 49ers Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Broncos 1-2 | o22.5-115 | u22.5-110 |
![]() 49ers 3-0 | o15.5-120 | u15.5-105 |