Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

12:30 am • NFL+

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Los Angeles Chargers

2-1

San Francisco 49ers

1-1

MatchupOpenSpreadTotalMoneyline
Chargers 2-1	+3	-2.5-107	o35.5-109	-135
49ers 1-1	u37.5	+2.5-117	u35.5-110	+113

Sunday 12:30 a.m.

August 24, 2025

Levi's StadiumSanta Clara

79°Fahrenheit

0%Rain

8Wind

Under 37.5-105

0.53u

🔗 https://whop.com/checkout/plan_EmUfhfnU87m47/?a=userd0a02663735&d2c=true

A Batch of Sharp, Week 3 Preseason Picks
Alex Kolodziej•
Aug 21, 2025 UTC

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NFL Public Betting

49ers are 2-3 in their last 5 games.
49ers are 2-3 in their last 5 games against the spread
49ers are 1-7 in their road games against the spread
The totals have gone OVER in 2 of 49ers' last 5 games
The totals have gone OVER in 5 of 49ers' 9 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	5-12	4-5	1-7	5-8	0-4
Chargers	12-4-1	5-2-1	7-2	11-2	1-2-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	10-7	5-4	5-3	7-6	3-1
Chargers	8-9	5-3	3-6	7-6	1-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	6-11	N/A	N/A	6-7	0-4
Chargers	11-6	N/A	N/A	11-2	0-4

date	opponent	score	spread	over/under	moneyline
Aug 16th	@LV	W 22-19	+4.5 W	O 40.5	SF +180
Aug 10th	DEN	L 9-30	+6.5 L	O 38.5	DEN +240
Jan 5th	@ARI	L 24-47	+5.5 L	O 43.5	ARI +195
Dec 31st	DET	L 34-40	+4 L	O 50.5	DET +182
Dec 22nd	@MIA	L 17-29	-1.5 L	O 44	MIA -125

Trevis Gipson
LB
Gipson is out with ankle
Out

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passing yards
Brock Purdy
3864
pyds
passing touchdowns
Brock Purdy
20
ptd
rushing yards
-
789
ryds
rushing touchdowns
Brock Purdy
5
rtd

	Starter	2ND	3RD	4TH
QB	Brock Purdy	Mac Jones	Kurtis Rourke	Carter Bradley
RB	Christian McCaffrey	Isaac Guerendo	Jordan James	Ke'Shawn Vaughn	Jeff Wilson
WR	Jauan Jennings	Jacob Cowing	Junior Bergen
TE	George Kittle	Luke Farrell	Brayden Willis	Jake Tonges
LT	Trent Williams	Spencer Burford	Isaac Alarcon
LG	Ben Bartch	Nick Zakelj
C	Jake Brendel	Matt Hennessy	Drake Nugent
RG	Dominick Puni	Connor Colby	Drew Moss
RT	Colton McKivitz	Austen Pleasants	Isaiah Prince
LDE	Nick Bosa	Robert Beal	Jonathan Garvin	William Bradley-King
RDE	Mykel Williams	Bryce Huff	Sam Okuayinonu	Trevis Gipson	Jaylon Allen
WLB	Dee Winters	Nick Martin	Curtis Robinson	Stone Blanton	Jalen Graham
MLB	Fred Warner	Luke Gifford	Tatum Bethune	Chazz Surratt
LCB	Renardo Green	Dallis Flowers	Jakob Robinson
SS	Ji'Ayir Brown	Richie Grant	Jaylen Mahoney
FS	Jason Pinnock	Marques Sigle	Siran Neal	Derrick Canteen
RCB	Deommodore Lenoir	Darrell Luter	Fabian Moreau
P	Thomas Morstead
H	Fabian Moreau
PR	Jacob Cowing	Junior Bergen	Jordan Watkins	Ricky Pearsall
KR	Isaac Guerendo	Junior Bergen	Dallis Flowers
LS	Jon Weeks
RWR	Ricky Pearsall	Jordan Watkins	Terique Owens	Robbie Chosen
K	Jake Moody
DT	Mykel Williams	Alfred Collins	Sebastian Valdez	Evan Anderson
LWR	Russell Gage	Isaiah Hodgins	Malik Turner
NT	Jordan Elliott	C.J. West	Kalia Davis	Bruce Hector
NB	Upton Stout	Chase Lucas
FB	Kyle Juszczyk

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MatchupOverUnder
Chargers 2-1	N/A	N/A
49ers 1-1	N/A	N/A

Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

Los Angeles Chargers

San Francisco 49ers

Chargers at 49ers Odds

Spread, Total, Moneyline

Chargers vs. 49ers Previews & Analysis

A Batch of Sharp, Week 3 Preseason Picks

Chargers vs. 49ers Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

Chargers vs. 49ers Public Betting Percentages

Chargers

Public

49ers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

49ers vs. Chargers Injury Updates

49ers Injuries

Chargers Injuries

Chargers vs. 49ers Odds Comparison

Chargers at 49ers Team Totals