The Arizona Cardinals (6-4) and Seattle Seahawks (5-5) face off in NFL Week 12 at 4:25 p.m. ET from Lumen Field in Seattle. The game will be broadcast on FOX and can be streamed on YouTube TV.
Cardinals vs. Seahawks odds (via BetMGM) have the Cardinals as -120 moneyline favorites and Seahawks as +100 underdogs. The over/under is set at 47 points (-110/-110). The Cardinals are -1.5 point favorites on the spread.
Let's get into my Cardinals vs. Seahawks prediction and NFL picks — plus betting trends, key injuries, weather forecast and more.
Cardinals vs. Seahawks Predictions
Spread
Despite the Cardinals' prowess early in games, which I'll go into in more detail below, I'm backing the Seahawks.
I'll take the point with Seattle and I'm also think about investing in futures.
Moneyline
If it gets to a pick'em, I'll bet Seattle. I'd prefer to take whatever point(s) I can get, though.
Over/Under
I have no pick on the game total for this game.
My Pick: Seahawks +1.5 (-110)
Cardinals vs. Seahawks Odds, Spread, Over/Under
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -110 | 47 -110o / -110u | -120 |
| Seahawks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -110 | 47 -110o / -110u | +100 |
- Cardinals vs. Seahawks spread: Cardinals -1.5 (-110), Seahawks +1.5 (-110)
- Cardinals vs. Seahawks over/under: 47 (-110/-110)
- Cardinals vs. Seahawks moneyline: Cardinals -120, Seahawks +100
- Cardinals vs. Seahawks best bet: Seahawks +1.5 (-110)
MySeahawks vs. Cardinals pick is on Seattle against the spread. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Cardinals vs. Seahawks Week 12 Preview, Prediction
This is a huge game in the NFC West, which is the only division with all four teams at .500 or better.
The Cardinals are one game ahead of the pack and 2-0 in divisional games. A win over the Seahawks would be massive and put a massive dent in Seattle’s playoff hopes.
The Cardinals defense has taken a huge leap in DVOA of late — up to No. 12 overall — as well as against the pass and run. I’m not sold on that, though, since that improvement might be down to playing the Bears and Jets in their last two games.
While I’m not sold on the Cardinals defense, their offense has a big edge here.
Arizona is first in first-quarter DVOA, while Seattle is 32nd. I wouldn’t hate playing the Cardinals over 3.5 first-quarter points at plus money.
Despite that, I still like Seattle in the matchup.
If you exclude a rough stretch from Weeks 4-6 when this unit was dealing with a variety of key injuries, the Seahawks defense ranks seventh overall, eighth against the pass and sixth against the run. Head coach Mike Macdonald has this unit playing much better, and holding the 49ers to 17 points last week is a great example.
The Seahawks defense also goes from No. 21 overall to flirting with the top 10 when playing at home. The Cardinals defense, meanwhile, goes from around the top five to 26th on the road.
I like Seattle in this matchup and would also recommend a futures bet in addition to it winning here.
The Seahawks are +600 to win the NFC West. The Cardinals face the Vikings on the road next week before playing the Seahawks again. Arizona closes the season on the road against the Rams and at home against the 49ers.
Speaking of the 49ers, their schedule gets tough. They face Green Bay this week before going to Buffalo next week. San Francisco also has to face the Rams, Dolphins (away) and Lions this season.
It’s not out of the realm of possibility that the Seahawks are in first place in the NFC West after Week 13, so let’s get ahead of it.
My Pick: Seahawks +1.5 (-110)
Cardinals vs. Seahawks Betting Trends
Cardinals vs. Seahawks Latest Injuries
Cardinals Injuries
| Player | Status |
|---|---|
| DB Jalen Thompson | Out (ankle) |
| DL Darius Robinson | Questionable (calf) |
| OT Jonah Williams | Questionable (knee) |
| LB Xavier Thomas | Questionable (back) |
Seahawks Injuries
| Player | Status |
|---|---|
| TE Brady Russell | Out (foot) |
| TE Noah Fant | Questionable (groin) |
| WR Laviska Shenault Jr. | Questionable (back) |
