Our football staff is focused on six of Sunday's biggest games for our NFL predictions in Week 13 on November 30.
First, we'll target up to five games in the early window: 49ers vs Browns, Texans vs Colts, Cardinals vs Buccaneers, Jaguars vs Titans and Saints vs Dolphins. Later in the afternoon, we have a pick for Raiders vs Chargers.
Let's dive into our expert NFL picks and best bets for the Week 13 Sunday slate.
NFL Predictions & Picks — Week 13
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 4:25 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
49ers vs. Browns
By Bet Labs
The weather will be a factor in this matchup between the 49ers and Browns, which is why our Bet Labs system targets the under for this early game on Sunday.
High Winds is an NFL system built on how weather directly impacts offensive efficiency and scoring potential.
When average wind speeds climb into the double digits, passing games struggle with accuracy, kicking becomes unreliable, and play calling leans more heavily toward conservative runs. For 49ers-Browns, Weather.com notes there could be winds of 25-35 mph with over a 70% chance of rain.
This naturally limits explosive plays and lowers scoring opportunities. With temperatures sitting in a reasonable range that does not drastically impact player stamina or ball handling, wind becomes the defining variable.
Both regular-season and postseason games fit this mold, as weather remains an equalizer regardless of stakes.
Betting the under in these conditions takes advantage of how the market often undervalues the true effect of sustained wind on football outcomes.
Pick: Under 36.5 (-115)
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Texans vs. Colts
C.J. Stroud is back at quarterback to complement this top-tier Texans defense.
The Texans are among the Rams, Bengals and Seahawks as the best defenses in the NFL, and they have arguably the best pass defense.
Houston has allowed the second-lowest EPA/play and ranks first in dropback EPA allowed (-0.127).
There is also a difference in the schedules these two teams have faced.
PFF has the Colts' schedule ranked 27th, whereas the Texans' strength of schedule is 13th.
Houston should keep this one close in Stroud's return.
Pick: Texans +3.5 (-110)
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Cardinals vs. Buccaneers
By Bet Labs
Our system backs the Cardinals on the moneyline as they visit the Buccaneers on Sunday.
Familiar Road Dogs is a system based on NFL teams that find themselves in the role of the underdog on the road in familiar conference matchups played in September October or November.
These games often carry added intensity because of conference familiarity where opponents know each other well and motivation is high even for weaker teams.
When the spread range is modest and shifts only slightly from open to close it signals that the market sees balance but may undervalue the road side.
In these spots, the road 'dog can benefit from motivation and preparation, while the home favorite may be overestimated.
With conference knowledge reducing the edge of home-field advantage and early-season volatility creating opportunities, these conditions combine to make road 'dogs more competitive than the market expects.
The Buccaneers carry some uncertainty this game. Specifically, quarterback Baker Mayfield is dealing with a sprained AC joint in his non-throwing shoulder. He's expected to play but carries re-injury risk.
Pick: Cardinals Moneyline +165
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Jaguars vs. Titans
The Titans are a frisky group of spread-covering tough competitors all of a sudden.
With the Jaguars off a West Coast overtime win, I can’t get to this number.
Our Chris Raybon also likes the Titans to cover this spread, noting that the Jaguars have not won by seven or more points on the road all season.
Pick: Titans +6 (-110)
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Saints vs. Dolphins
By Bet Labs
This Bet Labs system recommends backing the Saints to cover the spread as away underdogs against the Dolphins.
Road Dog Low Total After Bad Season focuses on how struggling NFL teams from the previous year can quietly outperform expectations when catching points on the road in lower-scoring games.
Teams with six or fewer wins from the prior season are often undervalued. Still, when they are priced as moderate underdogs in contests with totals capped at fifty, the environment favors closer outcomes and makes points more valuable.
Playing on Sundays or Mondays in September or late in the year amplifies this effect, as early games offer a chance for redemption while late-season contests often bring unique motivations and divisional familiarity.
In these situations, public bias against bad teams collides with the natural tendency for low total games to stay tight, creating profitable opportunities for road underdogs to cover.
Our Chris Raybon is notably taking a shot on the Saints moneyline in this game.
Pick: Saints +5.5 (-110)
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Raiders vs. Chargers
By Bet Labs
On Sunday, this system picks the Raiders against the spread versus the Chargers.
Small Bad Away Dogs in the NFL captures how teams that were poor the previous season but enter the new year as underdogs on the road or at neutral sites often exceed expectations when the spread is modest.
Both oddsmakers and bettors usually overlook teams with few wins from the prior year, yet these squads can show meaningful improvement with roster changes, draft additions, or coaching adjustments.
Being priced as small underdogs rather than large ones suggests the market already sees potential, but not enough to account for the motivational edge and element of surprise that these teams often bring.
Playing in the regular season, when effort is high and opportunities to reset a narrative are strongest, creates a profitable window in which small underdogs with bad histories prove undervalued and capable of covering spreads consistently.
Pick: Raiders +9.5 (-110)
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