The 49ers (12-4) host the Seahawks (13-3) tonight in a battle for the NFC West crown and No. 1 seed in the NFC. Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8 p.m. ET. Seahawks vs 49ers will broadcast on ESPN and ABC.
Seahawks vs 49ers odds list the Seahawks as -145 moneyline favorites and 49ers as +120 underdogs. The over/under is 47.5 points (-105o / -115u). The Seahawks are 2.5-point favorites on the spread over the 49ers (-115).
Below, you can find our Seahawks vs 49ers picks and props for Christian McCaffrey, Jauan Jennings, and Sam Darnold. Our NFL best bets for this game also include predictions for the game total and two 49ers futures.
Seahawks vs 49ers Picks & Props
| Game | Time (ET) | Best Bet |
|---|---|---|
  | 8 p.m. | |
| 8 p.m. | |
| 8 p.m. | |
| 8 p.m. | |
| 8 p.m. | |
| 8 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Seahawks vs 49ers Odds
| Seahawks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -115 | 47.5 -105o / -115u | -145 |
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -105 | 47.5 -105o / -115u | +120 |
NFL odds via bet365
Seahawks vs 49ers Over/Under Prediction
The 49ers are an over team. Their offense is virtually unstoppable and their pass rush on defense is non-existent.
With rain in the forecast, this total has come down from 49.5 at opening to 47.5. With the extra couple points of value, I am going to hope the downpour doesn’t hinder the passing games to the point of it turning into a sloppy game, and instead, it slows down the pass rush of the Seahawks’ defensive front.
Games involving the Niners have seen the over cash in five of their last seven games. Since Week 9, the 49ers defense has generated nine sacks, the fewest in the NFL.
Sam Darnold’s passer rating is exactly 40 points higher when throwing from a clean pocket as opposed to when he is pressured (111.2 vs. 71.2).
One reason I project success for Brock Purdy and the 49ers offense against this Seattle unit is that the Seahawks deploy zone coverage at the fifth-highest rate in the NFL at 77%. Purdy averages 8.7 yards per attempt and is 8% above expectation in terms of completion percentage against zone coverage this season. For context, Drake Maye is the only starting quarterback averaging more than 8.7 yards per pass attempt this season against all coverages.
Waiting closer to gametime may actually help you get a better number as bettors receive the information about the weather report. I would play this total over up to 48.
Pick: Over -47.5 (-110); Bet to 48
Christian McCaffrey Props: Will Seattle Contain CMC?
By Nick Giffen
This line is way too high considering the opponent. It is being inflated by big Christian McCaffrey runs in each of the last two weeks and him clearing this in five of his last eight games.
But those games McCaffrey cleared this line came against mostly bad run defenses (by DVOA): Chicago (28th), Indianapolis (14th), Carolina (25th), Arizona (26th), and the New York Giants (32nd).
Against top-10 run defenses by DVOA, McCaffrey has 114 rushing attempts in seven games, with a longest run of just 13 yards. Yes, that came against Seattle, but that is probably more of a fluke given Seattle ranks No. 1 in defensive rush DVOA and has allowed the lowest explosive run rate in the league.
San Francisco star LT Trent Williams is not expected to play, which would hurt CMC even more in this market.
This line is just way too high. I'd play this down to under 11.5 and feel good about it.
Pick: Christian McCaffrey Longest Rush Under 13.5 Yards (-109)
Sam Darnold Props: Sam Will Sling It
This line is a bit too low given the spot.
The Seahawks are a run-first team, but they will likely be forced to throw the ball a decent amount. The 49ers defense has been torched recently, allowing 89 points combined over their last three games to the Bears, Colts and Titans.
The Seahawks pass defense has been good this season, and the 49ers pressure opposing QBs at an incredibly low rate. Add in that the 49ers' offense has been scoring at will over the last month, and this is likely going to be a high-paced game.
I have Darnold projected for 20 yards over this number.
Pick: Sam Darnold Over 237.5 Passing Yards (-110)
Jauan Jennings Anytime TD Pick
By Grant Neiffer
Crushing it on a weekly basis, I have no choice but to go back to the well with Jauan Jennings in the anytime touchdown market.
Jennings has eight TDs in the last eight games and has scored in each of those games but one.
The matchup is a tough one against the Seahawks, but there's a chance that George Kittle doesn't play, which would lead to even more volume for Jennings.
I have Jennings' true odds around +120.
Pick: Jauan Jennings Anytime Touchdown Scorer (+190)
Christian McCaffrey Receptions Escalator; 49ers Futures
This is the most important game of the season, and not just for the regular season. My numbers have the winner here virtually doubling their chances to win the NFC and Super Bowl — so that's really the only way to play a side or moneyline here.
Awards could be in play too, with all eyes on such a huge matchup and one last chance to sway voters.
I still think Christian McCaffrey is live for Offensive Player of the Year and worth a play at +380 (FanDuel).
I like his receptions escalator at 6+ (+125, Fanatics), 7+ at +210 (Caesars), and 8+ at +390 (Caesars), and if he has a big game in a head-to-head win against Jaxon Smith-Njigba, McCaffrey could still steal OPOY. JSN has tailed off, with under 80 YPG over his last five outings with just one 100-yard game, about two-thirds his pace the rest of the season.
Picks: Christian McCaffrey Receptions Escalator 6+ to 8+ (+125 to +390)
If you think Seattle wins, could Mike MacDonald win Coach of the Year for a 1-seed built entirely on defense? He looks too long at +750 (DraftKings). Nick Emmanwori also looks in play for Defensive Rookie of the Year at +1000 (FanDuel) in an open race, if he can just make one huge play in a game everyone's watching.
If you prefer team futures, 49ers futures look like the way to go.
San Francisco is near a coin flip here thanks to home field, and a win would dramatically improve the 49ers' chances going forward — just three more home wins away from a title, since San Francisco hosts the Super Bowl.
A win clinches the 1-seed and a bye week, and it could also mean lucking into a Divisional Round game against the injured Packers or maybe even an NFC South team. That's a huge upside swing for the 49ers, who likely become Super Bowl favorites with a win Saturday.
I'd put the 49ers around 30% to win the NFC with a win and above 15% to win it all, dropping to 12% and 6% respectively with a loss.
That means there's value betting the 49ers to win the NFC at +500 and Super Bowl at +1100 (both FanDuel) since those implied odds at 16.7% and 8.3% have far more to gain than lose if San Francisco gets the win on Saturday night.
Picks: 49ers to Win NFC (+500); 49ers to Win Super Bowl (+1100)
