Astros vs. Angels Odds & Betting Predictions - September 27, 2025

Astros at Angels

1:38 am • SCHN
3 - 4
Starting Pitchers
pitcherteameraw-l
Kyle Hendricks logoK.HendricksLos Angeles Angels logo4.768-10
Jason Alexander logoJ.AlexanderHouston Astros logo3.664-2

Astros at Angels Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
87-75
-1.5
-1.5+120
o9-108
-133
Angels
72-90
u9
+1.5-142
u9-111
+110
location pinSaturday 1:38 a.m.
September 27, 2025
Angel StadiumAnaheim
Astros vs. Angels Expert Picks
Wags Wins
Wags Wins
Last 30d: 164-148-1 (+10.9u)
LAA +120
1.2u
Picks Office
Picks Office
Last 30d: 64-88-4 (-20.9u)
LAA +120
1.2u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 51-65-5 (+0.3u)
LAA +130
1.3u
Favorite Underdog @cowhitchurch @DerekCarty https://myaction.app/FCcmFCGSYWb
Sean Zerillo
Sean Zerillo
Last 30d: 148-184-4 (-15.4u)
LAA +130
0.65u
Bet to +120

Astros vs. Angels Previews & Analysis

  • Astros vs Angels: Value on This ML Bet article feature image

    Astros vs Angels: Value on This ML Bet

    Collin Whitchurch•
    Sep 26, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Angels Public Betting Percentages

Away Logo

Astros

Public

80%

Bets%

20%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Angels
85-7744-3741-4013-2570-52
Astros
82-8037-4445-3643-6039-18

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Angels
86-72-444-34-342-38-121-16-164-55-3
Astros
72-83-736-43-236-40-545-56-225-27-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Angels
72-9039-4233-4819-1951-71
Astros
87-7546-3541-4056-4731-26

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 26thKCL 4-9+1.5 LO 9.5KC +112
Sep 25thKCW 3-2+1.5 WU 8.5LAA -106
Sep 24thKCL 4-8+1.5 LO 9KC +140
Sep 21st@COLL 1-3-1.5 LU 11.5COL -107
Sep 21st@COLW 3-0-1.5 WU 11.5LAA -127

Angels vs. Astros Injury Updates

Angels Injuries

  • Anthony Rendon
    3B

    Rendon is out with hip

    Out

  • Gustavo Campero
    RF

    Campero is out with ankle

    Out

Astros Injuries

  • Pedro Leon
    RF

    Leon is out with knee

    Out

  • Hayden Wesneski
    RP

    Wesneski is out with elbow

    Out

Astros vs. Angels Box Score
Astros Player Stats
Projected
PITCHERPCIPKER
Jason Alexander logoRJ.Alexander, P564.242
Steven Okert logoLS.Okert, P190.200
Jayden Murray logoRJ.Murray, P171.101
Bryan King logoLB.King, P130.201
Bryan Abreu logoRB.Abreu, P80.200
HITTERSH-ABRHRRBI
Jose Altuve logo1J.Altuve, 2B0-3000
Isaac Paredes logo2I.Paredes, DH0-4000
Carlos Correa logo3C.Correa, SS2-4000
Christian Walker logo4C.Walker, 1B1-4111
Yainer Diaz logo5Y.Diaz, C2-4100
Zachary Cole logo6Z.Cole, CF1-3101
Victor Caratini logo6V.Caratini, PH0-1000
Taylor Trammell logo6T.Trammell, LF0-0000
Cameron Smith logo7C.Smith, RF0-3000
Jesus Sanchez logo7J.Sanchez, PH0-1000
Ramon Urias logo8R.Urias, 3B0-4000
Mauricio Dubon logo9M.Dubon, LF0-4000
Mauricio Dubon logo9M.Dubon, CF0-4000
Angels Player Stats
Projected
PITCHERPCIPKER
Kyle Hendricks logoRK.Hendricks, P108582
Chase Silseth logoRC.Silseth, P14120
Jose Fermin logoRJ.Fermin, P19100
Brock Burke logoLB.Burke, P17100
Kenley Jansen logoRK.Jansen, P19130
HITTERSH-ABRHRRBI
Nolan Schanuel logo1N.Schanuel, 1B0-4000
Michael Trout logo2M.Trout, DH2-4222
Joseph Ward logo3T.Ward, LF0-2000
Jordon Adell logo4J.Adell, RF0-4000
Luis Rengifo logo5L.Rengifo, 3B1-4000
Logan O'Hoppe logo6L.O'Hoppe, C0-3000
Christian Moore logo7C.Moore, 2B1-2100
Denzer Guzman logo8D.Guzman, SS2-3101
Bryce Teodosio logo9B.Teodosio, CF1-2000
Yoan Moncada logo9Y.Moncada, PH0-0000
Christopher Taylor logo9C.Taylor, PH1-1001
Christopher Taylor logo9C.Taylor, CF1-1001

Astros vs. Angels Odds Comparison

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Astros at Angels Team Totals

MatchupOverUnder
Astros
87-75
o4.5-126
u4.5-102
Angels
72-90
o3.5-143
u3.5+112