Cardinals vs. Cubs Odds & Betting Predictions - September 26, 2025

Cardinals at Cubs

6:20 pm • MLB Network

St. Louis Cardinals

1

1 - 12

Chicago Cubs

12

pitcher		team	era	w-l
C.Rea			3.95	11-7
M.Mikolas			4.84	8-11

MatchupOpenSpreadTotalMoneyline
Cardinals 40-33	+1.5	+1.5-126	o9-103	+154
Cubs 39-36	u9	-1.5+105	u9-118	-184

location pin

Friday 6:20 p.m.

September 26, 2025

Wrigley FieldChicago

Under 5 (F5)-114

1u

Under 9-115

0.58u

Fingers crossed that Miles Mikolas doesn’t implode on us 🤞

Over 9-102

0.98u

Under 9-118

0.59u

Bet to -125

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Sep 26, 2025 UTC
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MLB Public Betting

Cubs are 3-2 in their last 5 games.
Cubs are 2-3 in their last 5 games against the spread
Cubs are 15-22 in their road games against the spread
The totals have gone OVER in 1 of Cubs' last 5 games
The totals have gone OVER in 19 of Cubs' 38 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	28-47	13-25	15-22	18-33	10-14
Cardinals	44-29	22-16	22-13	9-6	35-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	38-37	19-19	19-18	24-27	14-10
Cardinals	31-38-4	17-19-2	14-19-2	5-9-1	25-29-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	39-36	22-16	17-20	28-23	11-13
Cardinals	40-33	21-17	19-16	11-4	29-28

date	opponent	score	spread	over/under	moneyline
Sep 25th	NYM	L 5-8	+1.5 L	O 7.5	NYM -103
Sep 25th	NYM	W 10-3	+1.5 W	O 7.5	CHC -118
Sep 23rd	NYM	L 7-9	+1.5 L	O 7.5	NYM +100
Sep 21st	@CIN	L 0-1	+1.5 W	U 9	CIN +105
Sep 20th	@CIN	L 3-6	-1.5 L	U 9	CIN -105

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out

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PITCHER		PC	IP	K	ER
RM.Mikolas, P		79	5	4	4
LJ.King, P		20	1	1	0
RG.Graceffo, P		31	0.1	1	5
RC.Roycroft, P		41	1.2	1	3

HITTERS	H-AB	R	HR	RBI
1L.Nootbaar, LF	0-3	0	0	0
2I.Herrera, DH	1-3	0	0	0
2J.Crooks, PH	0-1	0	0	0
2J.Crooks, DH	0-1	0	0	0
3A.Burleson, 1B	0-2	0	0	0
3Y.Pozo, PH	0-1	0	0	0
3Y.Pozo, 1B	0-1	0	0	0
4N.Arenado, 3B	0-3	0	0	0
4J.Fermin, PH	0-1	0	0	0
4J.Fermin, 2B	0-1	0	0	0
5N.Gorman, 2B	2-4	1	0	0
5N.Gorman, 3B	2-4	1	0	0
6T.Saggese, SS	1-4	0	0	0
7P.Pages, C	0-4	0	0	0
8J.Walker, RF	1-3	0	0	1
9V.Scott, CF	0-3	0	0	0

PITCHER		PC	IP	K	ER
RC.Rea, P		77	5.2	7	0
LC.Thielbar, P		11	0.1	1	1
RA.Kittredge, P		18	1	3	0
RD.Palencia, P		10	1	1	0
RB.Keller, P		13	1	2	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	2-3	2	1	2
1M.Ballesteros, PH	1-1	1	0	0
1M.Ballesteros, 1B	1-1	1	0	0
2N.Hoerner, 2B	2-5	2	1	1
3I.Happ, LF	2-4	1	0	1
3K.Alcantara, LF	1-1	0	0	1
4K.Tucker, DH	1-4	2	0	0
5S.Suzuki, RF	1-4	1	1	4
6P.Crow-Armstrong, CF	1-3	1	1	2
7D.Swanson, SS	0-3	1	0	0
8R.McGuire, C	0-4	0	0	0
9M.Shaw, 3B	1-4	1	0	1

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MatchupOverUnder
Cardinals 40-33	N/A	N/A
Cubs 39-36	N/A	N/A