Cubs vs. Pirates Odds & Betting Predictions - September 16, 2025

Cubs at Pirates

10:40 pm • SportsNet PT

Chicago Cubs

3-4

4 - 1

Pittsburgh Pirates

5-3

pitcher		team	era	w-l
P.Skenes			1.97	10-10
C.Horton			2.67	11-4

MatchupOpenSpreadTotalMoneyline
Cubs 3-4	+1.5	+1.5-209	o6.5-117	+111
Pirates 5-3	u7	-1.5+172	u6.5-105	-131

Tuesday 10:40 p.m.

September 16, 2025

PNC ParkPittsburgh

Under 0.5 (1st Inn)-170

0.86u

CHC +110

1.1u

Under 6.5+100

CHC +145 (F5)

1.45u

P.Skenes u6.5 Ks+115

1.15u

@DerekCarty https://myaction.app/F6GEecjhIWb

CHC +120

1.2u

@cowhitchurch https://myaction.app/F6GEecjhIWb

CHC +120

0.6u

C.Horton o4.5 Ks+103

0.5u

P.Skenes u6.5 Ks+115

0.49u

PIT -125

CHC +115

0.58u

Bet to +108

CHC +110

1.1u

Skenes pulled after 64 pitches last start. PIT has been conserving young pitchers recently - CHC much better offense, defense, bullpen and base running.

Cubs vs Pirates: Workload Could Tip the Balance
Collin Whitchurch•
Sep 16, 2025 UTC

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No props found

MLB Public Betting

Pirates are 4-1 in their last 5 games.
Pirates are 4-1 in their last 5 games against the spread
Pirates are 3-3 in their road games against the spread
The totals have gone OVER in 3 of Pirates' last 5 games
The totals have gone OVER in 1 of Pirates' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pirates	5-3	2-0	3-3	3-0	2-3
Cubs	3-4	3-3	0-1	3-3	0-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pirates	4-4	1-1	3-3	2-1	2-3
Cubs	3-4	3-3	0-1	3-3	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pirates	5-3	2-0	3-3	3-0	2-3
Cubs	3-4	3-3	0-1	3-3	0-1

date	opponent	score	spread	over/under	moneyline
Sep 15th	CHC	L 0-4	+1.5 L	U 8	CHC +102
Sep 14th	@WSH	L 3-4	-1.5 L	U 8.5	WSH -120
Sep 13th	@WSH	W 5-1	-1.5 W	U 9	PIT -115
Sep 12th	@WSH	L 5-6	-1.5 L	O 8.5	WSH -110
Sep 11th	@BAL	L 2-3	+1.5 W	U 8	BAL +105

Jared Jones
SP
Jones is out with elbow
Out

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out
Seiya Suzuki
RF
Suzuki is out with knee
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RC.Horton, P	79	5	6	1
LD.Pomeranz, P	15	1	2	0
RA.Kittredge, P	11	1	2	0
LC.Thielbar, P	12	1	0	0
RB.Keller, P	12	1	2	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	3-4	2	1	1
2N.Hoerner, 2B	3-5	0	0	0
3I.Happ, LF	0-2	1	0	1
4M.Ballesteros, DH	2-4	1	0	0
5C.Kelly, C	2-5	0	0	0
6P.Crow-Armstrong, CF	1-4	0	0	2
7D.Swanson, SS	2-4	0	0	0
8W.Castro, RF	0-5	0	0	0
9M.Shaw, 3B	1-4	0	0	0

PITCHER	PC	IP	K	ER
RP.Skenes, P	92	3.2	6	3
LE.Sisk, P	21	1	1	1
RJ.Lawrence, P	17	1.1	1	0
RC.Mlodzinski, P	55	3	5	0

HITTERS	H-AB	R	RBI
1J.Triolo, 3B	0-4	0	0
2S.Horwitz, 1B	1-3	1	0
3B.Reynolds, DH	0-4	0	0
4O.Cruz, CF	1-4	0	1
5N.Gonzales, SS	0-4	0	0
6J.Suwinski, LF	0-3	0	0
7N.Yorke, 2B	0-3	0	0
8A.Canario, RF	1-3	0	0
9H.Davis, C	1-3	0	0